DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITGAM and Itgam

DIOPT Version :10

Sequence 1:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens
Sequence 2:NP_001076429.1 Gene:Itgam / 16409 MGIID:96607 Length:1154 Species:Mus musculus


Alignment Length:1154 Identity:864/1154 - (74%)
Similarity:1004/1154 - (87%) Gaps:1/1154 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQ 65
            |.|:.||:|||.||||||||||:.|||||||:|||||||||.|:.|||.||||..|.||.|:|||
Mouse     1 MTLKALLVTALALCHGFNLDTEHPMTFQENAKGFGQSVVQLGGTSVVVAAPQEAKAVNQTGALYQ 65

Human    66 CDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNL 130
            |||||..|.||.||||.||||||||||||.:|.|.|||||||||||.|.|||||.|||:||||||
Mouse    66 CDYSTSRCHPIPLQVPPEAVNMSLGLSLAVSTVPQQLLACGPTVHQNCKENTYVNGLCYLFGSNL 130

Human   131 RQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEE 195
            .:.||:||||||.|||::|||.|||||||||...||::|||||||||||.|||||||||||||:|
Mouse   131 LRPPQQFPEALRECPQQESDIVFLIDGSGSINNIDFQKMKEFVSTVMEQFKKSKTLFSLMQYSDE 195

Human   196 FRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGE 260
            |||||||.:|:.||:|||.|.||.||.|||.||:||||||||||:.|||||:||.||||||||||
Mouse   196 FRIHFTFNDFKRNPSPRSHVSPIKQLNGRTKTASGIRKVVRELFHKTNGARENAAKILVVITDGE 260

Human   261 KFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQ 325
            ||||||.|:||||||||.||||||||||:||...:||:||:||||||..:|||||:|||||.|||
Mouse   261 KFGDPLDYKDVIPEADRAGVIRYVIGVGNAFNKPQSRRELDTIASKPAGEHVFQVDNFEALNTIQ 325

Human   326 NQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFI 390
            |||:|||||||||||||:||||||||||||||:||||||||.:|||:|||||.||||||:|.|||
Mouse   326 NQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASITSNGPLLGSVGSFDWAGGAFLYTSKDKVTFI 390

Human   391 NMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGA 455
            |.|||||||||||||||:|:||||||||||||||||||||||.|||:|.|.||.:.::||:|||:
Mouse   391 NTTRVDSDMNDAYLGYASAVILRNRVQSLVLGAPRYQHIGLVVMFRENFGTWEPHTSIKGSQIGS 455

Human   456 YFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQRARWQCDAVLYGEQGQPWGR 520
            ||||||||||:|::|:|:|:|||||||||:|||||||||||||||||||||:|:|:|:||.||||
Mouse   456 YFGASLCSVDMDADGNTNLILIGAPHYYEKTRGGQVSVCPLPRGQRARWQCEALLHGDQGHPWGR 520

Human   521 FGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFG 585
            ||||||||||||||||||||||||||::|:||||:|:|.|.:.:|.||||||.|:..||.|||||
Mouse   521 FGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFYGASIASLSASHSQRIIGAHFSPGLQYFG 585

Human   586 QSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAG 650
            ||||||:|||||||:||.||||||:||||:|||||::|.|||:|::|||:||.|.:||:|.|:||
Mouse   586 QSLSGGKDLTMDGLMDLAVGAQGHLLLLRAQPVLRLEATMEFSPKKVARSVFACQEQVLKNKDAG 650

Human   651 EVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETL 715
            ||||||.|:|:|:||||||.|||.||||||||.||...||.|:||||:|||:|||.||.|.||||
Mouse   651 EVRVCLRVRKNTKDRLREGDIQSTVTYDLALDPGRSRIRAFFDETKNNTRRRTQVFGLMQKCETL 715

Human   716 KLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDD 780
            ||.||:|::|.||||:||||::|||.||.:|||||||||.||||.|||:||||||||||:|||||
Mouse   716 KLILPDCVDDSVSPIILRLNYTLVGEPLRSFGNLRPVLAMDAQRFFTAMFPFEKNCGNDSICQDD 780

Human   781 LSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWR 845
            ||||.|.|.||.||||||::||::||:||||||||.||||.::|..|||||.|..||..:::.|.
Mouse   781 LSITMSAMGLDTLVVGGPQDFNMSVTLRNDGEDSYGTQVTVYYPSGLSYRKDSASQNPLTKKPWF 845

Human   846 L-ACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMP 909
            : ..||:||:|..||||||:.:|||||||.|||||||:||||||.||.||||||||.|.|||||.
Mouse   846 VKPAESSSSSEGHGALKSTTWNINHPIFPANSEVTFNVTFDVDSHASFGNKLLLKAIVASENNMS 910

Human   910 RTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLV 974
            ||:||:||||||||||:||:|||...|.:||||||||.||:|:|||||.:||||||||:|:||.:
Mouse   911 RTHKTKFQLELPVKYAIYMIVTSDESSIRYLNFTASEMTSKVIQHQYQFNNLGQRSLPVSVVFWI 975

Human   975 PVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFG 1039
            ||::|...:||.|||.||:||||.|||:::.|.||:|..:|.:.||:|||:|||:|||||:|.|.
Mouse   976 PVQINNVTVWDHPQVIFSQNLSSACHTEQKSPPHSNFRDQLERTPVLNCSVAVCKRIQCDLPSFN 1040

Human  1040 IQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVP 1104
            .||.||.||||||||||||||||.|||:||:.|||||||.|.|||||.::|||:|||||||:||.
Mouse  1041 TQEIFNVTLKGNLSFDWYIKTSHGHLLLVSSTEILFNDSAFALLPGQESYVRSKTETKVEPYEVH 1105

Human  1105 NPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ 1153
            ||:|||||||:|||:|||||||.|||||||||||||||:|..|..|.||
Mouse  1106 NPVPLIVGSSIGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQDAPPQ 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 42/56 (75%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 45/58 (78%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 136/174 (78%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 42/50 (84%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 44/50 (88%)
Int_alpha 453..>495 CDD:214549 33/41 (80%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 43/57 (75%)
Int_alpha 517..563 CDD:214549 38/45 (84%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 45/59 (76%)
Integrin_alpha2 616..979 CDD:462478 256/363 (71%)
Integrin_alpha 1130..1144 CDD:459778 13/13 (100%)
GFFKR motif 1132..1136 3/3 (100%)
ItgamNP_001076429.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 42/56 (75%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 45/58 (78%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 136/174 (78%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 42/50 (84%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 44/50 (88%)
Int_alpha 453..>495 CDD:214549 33/41 (80%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 43/57 (75%)
Int_alpha 517..>558 CDD:214549 36/40 (90%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 45/59 (76%)
Int_alpha 582..>620 CDD:214549 32/37 (86%)
Integrin_alpha2 616..1034 CDD:462478 286/417 (69%)
Integrin_alpha 1131..1143 CDD:459778 11/11 (100%)
GFFKR motif 1133..1137 3/3 (100%)

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