Protein Alignment ITGAM and itgam.1

DIOPT Version :10

• Sequence 1: NP_001139280.1
• Gene: ITGAM / 3684
• HGNCID: 6149
• Length: 1153
• Species: Homo sapiens
• Sequence 2: XP_005156064.3
• Gene: itgam.1 / 101882585
• ZFINID: ZDB-GENE-110411-175
• Length: 1136
• Species: Danio rerio
• Alignment Length: 1157
• Identity: 428/1157 - (36%)
• Similarity: 650/1157 - (56%)
• Gaps: 62/1157 - (5%)

Human    17 FNLDTENAMTFQ---ENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRL 78
            ||:|.....||.   .|...||..|:|...:|:.|..|...:..::||.:|.||.:.|:|..:.:
Zfish    22 FNVDHAAWKTFTAPLTNNVAFGYKVIQEDMTRLTVSDPLIQINRDERGQIYSCDVNRGTCSSLNI 86

Human    79 --QVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEAL 141
              :||.||||||||||:.......:|:.||||:.:.|...:...|:||: ..:.|......|.:|
Zfish    87 YGRVPSEAVNMSLGLSMVKDPGSSKLVVCGPTIPKNCPGVSTYNGMCFV-NEHRRSFTGPIPSSL 150

Human   142 RGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQ 206
            |.||:...|||||:|||||:.|.||.:||.||..:::......|.|::.|:|.|..||:.|::.:
Zfish   151 RECPKSQIDIAFLLDGSGSVDPVDFNKMKAFVVEMIKSFIDRDTQFAIAQFSTECVIHYKFQQVK 215

Human   207 NNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGE---KFGDPLGY 268
            |....:..|..|.|..|.|.|||.||.:|..||..:.|||::|.||||||||||   ||     .
Zfish   216 NPAWWQRAVNGIQQTHGWTFTATAIRLLVESLFVSSGGARQSASKILVVITDGESNDKF-----L 275

Human   269 EDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIF 333
            .:.:.:|..:.:.||.||||:||....:|.||..|||.|...|||:|.:|:||::|:..|:|.|.
Zfish   276 TEAVQQAQEKSITRYAIGVGNAFNKYSARNELTVIASIPTDKHVFKVTDFDALESIREILKENII 340

Human   334 AIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLST-VGSYDWAGGVFLYTSKEKSTFINMTRVDS 397
            |||||||...|| ..|.:|:|||||:||:..|:.| ||::.|.||..|:...:::   ::.:..|
Zfish   341 AIEGTQTSGDSS-RMEFAQDGFSAALTSDTDLIMTAVGAFQWKGGYQLFKLNDQT---SVFQAGS 401

Human   398 DMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLC 462
            :.| :||||:.||......:..|:||||::|.|||.:.|.:....:...:...||||:||||.:|
Zfish   402 EHN-SYLGYSLAIATVYNTKYAVMGAPRHKHEGLVTVTRIDRMSDQIQLDPPKTQIGSYFGAEVC 465

Human   463 SVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQRARWQCDAVLYGEQGQPWGRFGAALTV 527
            .||::|:.:|||:|:.||.|.|..|.|:|.|....|.....:. |.||.|..||. ||||::|..
Zfish   466 VVDLNSDSNTDLLLVSAPTYTESEREGKVFVYSYTRRPFFSFS-DVVLVGMAGQR-GRFGSSLAS 528

Human   528 LGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLS-GG 591
            ..|:|||...||.:|||.|||.:|::|:|:|..| ||..|:|||||||.:...|||||.||| ..
Zfish   529 PADLNGDGFKDVLVGAPLEEDGKGSIYIFNGRDG-GIISSYSQRIAGSSVQSGLQYFGVSLSQSS 592

Human   592 QDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCL 656
            .|.|.|.|.|:.||::|.||||||:|::.::..:.:||.:::....:|.:|:     ...:.||.
Zfish   593 PDQTADSLPDIAVGSKGAVLLLRSRPIMLLETKVSYNPSKISTGHTDCKNQL-----QTTLIVCF 652

Human   657 HVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPN 721
             ..|..|...|:  :.:.:||::.||:.|.:.||.|: .|::.......:|.|:.|:.....:..
Zfish   653 -TMKGYRHHKRD--LNAKITYNITLDAKRQNHRAFFS-AKDNLLSNVIDIGNTEVCKNHDFLIEA 713

Human   722 CIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFS 786
            |.||.::|:..:|.|:..|.|.|...||||:|..:.:........||:.||.||:|.|:|.:.|:
Zfish   714 CPEDALNPLSNQLKFTFEGLPSSQMQNLRPILLPEIKTTSDHDLDFERECGKDNVCVDNLRVDFN 778

Human   787 FMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESA 851
            |.....:.||..:|.||||.|.|.||:||.|..|..:|...|||::::.|.       |:.|.|.
Zfish   779 FSGSTNIEVGIMQEINVTVFVENRGENSYNTHFTLNYPYGFSYRRITSKQG-------RVECSSL 836

Human   852 SSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNM-PRTNKTE 915
            .. |....|..|.|:|:.||..:|:::.|.||:.::.:.:||..::..|:|.|.|:. ..:::..
Zfish   837 DG-EQGVRLGETECAISKPILKDNTKIVFEITYSINKEVTLGQNVIFSASVKSGNDKHSESSELS 900

Human   916 FQLELPVKYAVYMVVTSHGVSTKYLNFTA-SENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLN 979
            .:..:.|||.:|:.:..|..||.::|||: .::.|:.:|...::.| ..|.|..:....||::|.
Zfish   901 KKKSIDVKYGIYVALIRHENSTIHINFTSGKKDLSKPVQQTIKIEN-DLRPLAFTAFIRVPLKLG 964

Human   980 QTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEE- 1043
            .|.||....:..|:.:.:    |...||.::::.:::|..|:|||:|||....||:..  |:.|
Zfish   965 DTDIWKESTLQVSDCVKN----KTEKPSVTNYMDDIKKHHVLNCSVAVCAVFICDVNL--IKNER 1023

Human  1044 --FNATLKGNLSFDWY----IKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFE 1102
              :|.|  ||:|..|.    :|::...|:..:|.:...:..||.....:......|..|:||.:|
Zfish  1024 KLYNIT--GNVSSAWIEQTGLKSAVFELVSTTTMDYDMSTYVFFSSDSRNTAPSLQISTQVEVYE 1086

Human  1103 VPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAE-PQ 1153
            ..:....|:|..:|||:|||||||||||.||||.|||.||.|.  .|.| ||
Zfish  1087 EVDLTKEIIGGVIGGLVLLALITAALYKAGFFKSQYKQMMEEA--QGEEAPQ 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	18..75		19/59 (32%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	76..135		22/60 (37%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	78/177 (44%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	339..390		21/51 (41%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	391..442		18/50 (36%)
		Int_alpha	453..>495	CDD:214549	22/41 (54%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..565		29/57 (51%)
		Int_alpha	517..563	CDD:214549	22/45 (49%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	570..630		30/60 (50%)
		Integrin_alpha2	616..979	CDD:462478	104/364 (29%)
		Integrin_alpha	1130..1144	CDD:459778	10/13 (77%)
		GFFKR motif	1132..1136		3/3 (100%)
itgam.1	XP_005156064.3	None