Protein Alignment ITGAM and LOC101735096

DIOPT Version :10

• Sequence 1: NP_001139280.1
• Gene: ITGAM / 3684
• HGNCID: 6149
• Length: 1153
• Species: Homo sapiens
• Sequence 2: XP_031749690.1
• Gene: LOC101735096 / 101735096
• XenbaseID: XB-GENE-29088291
• Length: 1157
• Species: Xenopus tropicalis
• Alignment Length: 1165
• Identity: 488/1165 - (41%)
• Similarity: 704/1165 - (60%)
• Gaps: 43/1165 - (3%)

Human     1 MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQ 65
            ::..:..:..|:...||.:||...:.||.....||..|||| |.||:|.||.:....|:.|:||.
 Frog     8 LSRNIWFIAVLSSADGFFVDTAQPIIFQNPDGSFGYQVVQL-GQRVIVSAPLQRDGVNKTGALYS 71

Human    66 CDYSTGSCEPIRLQVPVEAVNMSLGLSLAA-TTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSN 129
            ||.||.||:.:.:....|.:.:||||::.. ..:|.||||||||:.:||.::.||.|.|:...|:
 Frog    72 CDPSTSSCQRVPINGSPEDIKISLGLTMVTQERNPSQLLACGPTLQRTCGQSIYVMGRCYQLDSS 136

Human   130 LRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSE 194
            ||.| |..|.:|..||....||||||||||||.|..|:.|..|||.|:|..:.:.|||::||||.
 Frog   137 LRHQ-QTLPPSLPECPVRSLDIAFLIDGSGSIDPDQFQEMLTFVSKVIEDFEGTDTLFAIMQYSN 200

Human   195 EFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDG 259
            .|..||.||:|....:.|.|:..||||.|.|.|||||:||:||||..::|:|..:.|.|:|||||
 Frog   201 LFTEHFNFKKFSAARDKRRLIWSITQLRGTTWTATGIQKVLRELFIPSSGSRHGSQKFLIVITDG 265

Human   260 EKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTI 324
            ||:||.|.|...|.||:..||:|:.||||.|||:.|:..|||||||||...:|::|::|.||...
 Frog   266 EKYGDTLDYSGPIAEAEGMGVVRFAIGVGGAFRNSKALNELNTIASKPSDKYVYKVSDFSALSKF 330

Human   325 QNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKE-KST 388
            :..|::|||||||.|..:.|.|:.||||:|||:.::::..:|..||:|||:||..:|...: |..
 Frog   331 RKDLQDKIFAIEGVQVNTGSGFQMEMSQDGFSSVLSADHIVLGAVGAYDWSGGASVYAKGQMKGV 395

Human   389 FINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQN--TGMWESNANVKGT 451
            :||.|:...||..||:|||   :.:...:.:.:|||||||.|.|.:::::  :..|...|.::|.
 Frog   396 WINETQDQKDMKAAYMGYA---VHQLSAKLIAIGAPRYQHTGSVLIYQKDLYSSNWNQRAVIRGE 457

Human   452 QIGAYFGASLCSVDVDSNGSTDLVLIGAPHYY-EQTRGGQVSVCPLPRGQRARWQCDAVLYGEQG 515
            :||:|||:.|....|:|..|..|:|:|||.|| ..|..|:|.:||:.........|...|.|:..
 Frog   458 KIGSYFGSVLNGGSVNSGSSQVLLLVGAPTYYTPDTPEGRVFLCPIHTRTSVTVSCPIALQGDPT 522

Human   516 QPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPR 580
            |.:|.||:|:.:|.|:.||.|.|:|:|||.|..|:||:|:|.|..| |...::.||||.|:::..
 Frog   523 QYFGHFGSAMCLLPDLTGDNLIDLAVGAPCENQNQGAIYIFPGQKG-GFRTAYIQRIASSQVAKG 586

Human   581 LQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVK 645
            |.:||:|:||..|:|.|.|.||:||..|.||:|||:.|:.|...|.|||.|:..:.:||.|....
 Frog   587 LMFFGRSMSGNLDMTRDSLPDLSVGGAGKVLILRSRTVVGVSVSMTFNPAEIPISSYECPDADTT 651

Human   646 GKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQ 710
             |.|..:.||:...:.:    ..|::.:.:||.|.||:||...|||| ..|..:.:||..|...:
 Frog   652 -KAATTIVVCVTCTRKS----PAGEVSAQMTYTLLLDAGRVQKRAVF-PGKEHSLQQTFPLRQGR 710

Human   711 TCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDN 775
            .|....:.||.|:||.:||:.:.|:|:|.|         :.||::|:....:....|:||||:|.
 Frog   711 NCIPYPITLPECVEDSLSPLSVALSFTLTG---------QSVLSQDSPTSLSEQVSFQKNCGSDG 766

Human   776 ICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRS 840
            .|||||.|..:|..|..||||...|.||.::|:|.|||||.::|...||..||||.||.:|:.|
 Frog   767 RCQDDLRINATFGDLRHLVVGVSLEVNVILSVQNHGEDSYNSRVIITFPSGLSYRMVSLIQSNR- 830

Human   841 QRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSE 905
                ||.....|:.|   ..:...|.||:|:...|:..||.::|.|.|.|.||.:|.:..||||:
 Frog   831 ----RLMTIKCSTPE---GERYVICGINNPLLRPNATATFLVSFHVSSLADLGKRLTITTNVTSD 888

Human   906 NNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTS--RVMQHQYQVSNLGQRSLPI 968
            |.....|..:...||.|.|.:|:.:||...||||.||:.|..:.  |.::|.|:|.|.|||||||
 Frog   889 NGGAPNNLMKSTAELKVLYGIYVTITSLEESTKYTNFSLSGRSPIVREVKHMYKVGNQGQRSLPI 953

Human   969 SLVFLVPVRLNQTVIWDRPQVTFSE----NLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQ 1029
            |::|:|||:|.:||:|::|.:|.||    |.:::|.....:.:..:|..:....||:||::..|.
 Frog   954 SIIFMVPVKLKETVVWEKPVITISEEGLSNSTTSCTNTGEITNTQEFQQQNEVRPVLNCTVMTCL 1018

Human  1030 RIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT-LLPGQGAFVRSQ 1093
            |..|.|....|.:..|.|:.|.::.||..:|:|..:|:.|:|||:::...:. :|.....|.|:|
 Frog  1019 RFVCSINSLDIHKSINFTITGQVTKDWATQTAHQKVLLQSSAEIMYDSERYQHILEQNQPFTRAQ 1083

Human  1094 TETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMS--EGGPPGAE 1151
            .:|.:|.|...|.||:|:|||||||:|||||||.|||:||||||||::|.  ||...|.|
 Frog  1084 AQTVLEVFTEYNYLPVIIGSSVGGLVLLALITAGLYKVGFFKRQYKELMELPEGETVGGE 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	18..75		26/56 (46%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	76..135		24/59 (41%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	95/174 (55%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	339..390		20/51 (39%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	391..442		18/52 (35%)
		Int_alpha	453..>495	CDD:214549	19/42 (45%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..565		26/57 (46%)
		Int_alpha	517..563	CDD:214549	22/45 (49%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	570..630		30/59 (51%)
		Integrin_alpha2	616..979	CDD:462478	139/364 (38%)
		Integrin_alpha	1130..1144	CDD:459778	10/15 (67%)
		GFFKR motif	1132..1136		3/3 (100%)
LOC101735096	XP_031749690.1	vWFA	155..327	CDD:469594	93/171 (54%)
		Int_alpha	459..515	CDD:214549	22/55 (40%)
		Int_alpha	525..578	CDD:214549	24/53 (45%)
		Integrin_alpha2	622..1022	CDD:462478	156/422 (37%)
		Integrin_alpha	1120..1133	CDD:459778	9/12 (75%)