Protein Alignment ITGAM and itgad

DIOPT Version :10

• Sequence 1: NP_001139280.1
• Gene: ITGAM / 3684
• HGNCID: 6149
• Length: 1153
• Species: Homo sapiens
• Sequence 2: XP_002940816.3
• Gene: itgad / 100495489
• XenbaseID: XB-GENE-6469652
• Length: 1174
• Species: Xenopus tropicalis
• Alignment Length: 1174
• Identity: 493/1174 - (41%)
• Similarity: 713/1174 - (60%)
• Gaps: 58/1174 - (4%)

Human     6 LLLTALTLCH------------GFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAAN 58
            ||||..||.|            ||.:||:..:|||...|.||..|||| ..||:|.||.:....|
 Frog    19 LLLTMATLLHWLLLGTVLPSADGFFVDTDRPITFQNPDRSFGYQVVQL-NQRVIVSAPLQQDGVN 82

Human    59 QRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATT-SPPQLLACGPTVHQTCSENTYVKGL 122
            :.|:||.||.||..|:.:.:....|.:|:||||::|... :|.||||||||:.:||.|:.||.|.
 Frog    83 KTGTLYSCDPSTSRCQRVPINGSPEDINISLGLTMAVQKGNPSQLLACGPTLQRTCGESIYVMGR 147

Human   123 CFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLF 187
            |:...|:||.| |..|.:|..||....||.|||||||||.|..|:.|..|||.|:|..|.:.|||
 Frog   148 CYQLDSSLRHQ-QTLPPSLPECPVRSLDIVFLIDGSGSIYPDQFQEMLTFVSKVIEDFKGTDTLF 211

Human   188 SLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKI 252
            ::||||..|.:||.|.:|....:..|||:.|.||.|.|.|||.|:||:.:||..:.|||..:.|:
 Frog   212 AIMQYSSWFVLHFDFNKFLATKDHNSLVRNINQLKGATWTATAIQKVLSQLFIPSRGARDGSQKL 276

Human   253 LVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNN 317
            |:|||||||:||.|.|...|.||:|:|::|:.||||.||..:.:..||.||||:|...:|::|.:
 Frog   277 LIVITDGEKYGDSLDYSIPIAEAERKGIVRFAIGVGRAFSEDTAYSELITIASQPSDKYVYRVGD 341

Human   318 FEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYT 382
            |.||...:..|::|||||||.|..:.|.|:.||||||||:.::::..:|..||:|||:||..:|.
 Frog   342 FSALSKFRKDLQDKIFAIEGVQVQTGSGFQMEMSQEGFSSVLSADHTVLGAVGAYDWSGGASVYA 406

Human   383 SKE-KSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQ--NTGMWES 444
            ..: |..:||.|:...||..||||||..::   ..:.:.:|||||||.|.|.::.:  ::..|..
 Frog   407 KGQMKGVWINETQDQKDMKAAYLGYAVHLL---SPKLIAIGAPRYQHTGGVLIYEKDLSSSNWNQ 468

Human   445 NANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYY-EQTRGGQVSVCPL-PRGQRARWQCD 507
            .|.::|.:||:|||:.|....|:|..|..|:|:|||.|| .:|:||:|.:||: .|....:..|.
 Frog   469 RAVIRGEKIGSYFGSVLNGGSVNSGSSQLLLLVGAPTYYTPETQGGRVFLCPINTRASVLQVTCP 533

Human   508 AVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRI 572
            ..|.|:..|.:|.||:|:.:|.|:.||.|||:|:|||.|:.|:||:|:|.|..| |...::.|||
 Frog   534 IALQGDPTQYFGHFGSAMCLLPDLTGDNLTDLAVGAPYEDQNQGAIYIFPGQKG-GFRTAYIQRI 597

Human   573 AGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVF 637
            |.|:::..|.:||:|:||..|:|.|.|.||::|..|.||:|||:.|:.|...:.|||.|:..:.:
 Frog   598 ASSQVAKGLMFFGRSMSGNLDMTRDSLPDLSIGGAGKVLILRSRTVVGVSVSITFNPTEIPISSY 662

Human   638 ECNDQVVKGKEAGEVRVCLH-VQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRR 701
            ||.|.... |.|..::||:. .:||:     .|.:.:.:||.|.||:.|...||||:.|:.|.::
 Frog   663 ECPDADTM-KAATTMKVCVTCTRKSS-----AGVVSAQMTYTLLLDADRTQKRAVFDGTERSLQK 721

Human   702 QTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFP 766
            :..:.. ...|.|..::||.|:||.:||:.:.|||:|.|         :.||:||:....:....
 Frog   722 KFPIKE-GNDCMTFSIRLPECVEDSLSPLRVALNFTLTG---------QSVLSEDSPTSLSEQVS 776

Human   767 FEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRK 831
            |:||||:|..|||||.|..:|..|..||||...|.|||::|:|.|||||.::|....|..||||:
 Frog   777 FQKNCGSDGRCQDDLRINATFGDLRHLVVGVSLEVNVTLSVQNYGEDSYNSRVIITHPSGLSYRR 841

Human   832 VSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKL 896
            ||..|:.|     ||.....|:.|   ..:...|.||:|:...::...|.::|.|.|.|.|||:|
 Frog   842 VSLSQSNR-----RLMIIKCSTPE---GERYVICGINNPLLRPSATAIFVVSFHVSSLADLGNRL 898

Human   897 LLKANVTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTS--RVMQHQYQVS 959
            .:..||||:|.....:..:...:|.|.|.:|:.:||...||||.|:::||.:.  |.::|.|:|.
 Frog   899 TITTNVTSDNGGAPNDLMKSTAQLKVLYGIYVTITSLEESTKYTNYSSSERSPIVRDVKHMYKVG 963

Human   960 NLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSE----NLSSTCHTKERLPSHSDFLAELRKAPV 1020
            |.||||||||::|:|||:|.:||:|:.|.:..||    |.::.|.....:.:..:||.|.....|
 Frog   964 NQGQRSLPISIIFMVPVKLKETVVWENPNIIVSEEELSNSTTNCTNTGEITNTGEFLEENEAHSV 1028

Human  1021 VNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT-LLP 1084
            :||::..|.|..|.|....||:..|.|:.|.::.||..:|:|..:|:.|:|||::|...:. :|.
 Frog  1029 LNCTVMTCLRFVCSIDSLNIQKSINFTITGKVTKDWATQTAHQKVLLQSSAEIVYNSERYQHILE 1093

Human  1085 GQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMS--EGGP 1147
            ....|.|:|.:|.:|.|...|.||:|:|||||||:|||||:|.|||:||||||||::|.  ||..
 Frog  1094 QNQPFTRAQAQTVLEVFIEYNYLPVIIGSSVGGLVLLALISAGLYKVGFFKRQYKELMELPEGET 1158

Human  1148 PGAE 1151
            .|.|
 Frog  1159 VGGE 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	18..75		26/56 (46%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	76..135		27/59 (46%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	88/174 (51%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	339..390		21/51 (41%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	391..442		19/52 (37%)
		Int_alpha	453..>495	CDD:214549	20/42 (48%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..565		27/57 (47%)
		Int_alpha	517..563	CDD:214549	23/45 (51%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	570..630		28/59 (47%)
		Integrin_alpha2	616..979	CDD:462478	137/365 (38%)
		Integrin_alpha	1130..1144	CDD:459778	10/15 (67%)
		GFFKR motif	1132..1136		3/3 (100%)
itgad	XP_002940816.3	vWFA	173..345	CDD:469594	86/171 (50%)
		Int_alpha	477..529	CDD:214549	23/51 (45%)
		Int_alpha	544..597	CDD:214549	25/53 (47%)
		Integrin_alpha2	641..1041	CDD:462478	154/423 (36%)
		Integrin_alpha	1139..1152	CDD:459778	9/12 (75%)