Protein Alignment CG7848 and MAE1

DIOPT Version :9

• Sequence 1: NP_611127.1
• Gene: CG7848 / 36839
• FlyBaseID: FBgn0034127
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_012896.1
• Gene: MAE1 / 853839
• SGDID: S000001512
• Length: 669
• Species: Saccharomyces cerevisiae
• Alignment Length: 643
• Identity: 173/643 - (26%)
• Similarity: 287/643 - (44%)
• Gaps: 65/643 - (10%)

  Fly     6 RMSRL-SAEKKKKKDDEKKDNAEEELQKNKELKCVSNYDKTEILDYMPRYMDTFWKMDTRLS--G 67
            :.||| |:..:..|....::|..::...::|:      .||.:.....:..:......|||:  |
Yeast    34 QQSRLYSSNTRSHKATTTRENTFQKPYSDEEV------TKTPVGSRARKIFEAPHPHATRLTVEG 92

  Fly    68 S---KVDGLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQQY 129
            :   .::...:||...:|||.|||..||...::..|||..|.|:|||.|.....|......:.:.
Yeast    93 AIECPLESFQLLNSPLFNKGSAFTQEEREAFNLEALLPPQVNTLDEQLERSYKQLCYLKTPLAKN 157

  Fly   130 IYLTYLSRRNRRLFYYLLLSNPDRFVPM--TDASGSIDLLMVHRMIHSMGQGLYICIKDLGHVSQ 192
            .::|.|..:|:.|::.|:..:....||:  |...|.......||.  ...:|:::.|.:...:..
Yeast   158 DFMTSLRVQNKVLYFALIRRHIKELVPIIYTPTEGDAIAAYSHRF--RKPEGVFLDITEPDSIEC 220

  Fly   193 ILSNW-PFRCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNN 256
            .|:.: ..:.|..::||:...:|.:||.|:..:.|..|.|....:.|||||...|.|.|||||||
Yeast   221 RLATYGGDKDVDYIVVSDSEGILGIGDQGIGGVRIAISKLALMTLCGGIHPGRVLPVCLDVGTNN 285

  Fly   257 EELLNDPMYTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQC 321
            ::|..|.:|.|.:..|...|.||...|:|..:|.:.| |.|::..:||..:.|::.||.||....
Yeast   286 KKLARDELYMGNKFSRIRGKQYDDFLEKFIKAVKKVY-PSAVLHFEDFGVKNARRLLEKYRYELP 349

  Fly   322 IVDVDFQCFAAVALAGVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIEMKARE 386
            ..:.|.|...||.:|.:|...:...........|.|||.:..:|:|...:..:...|:.:.:||:
Yeast   350 SFNDDIQGTGAVVMASLIAALKHTNRDLKDTRVLIYGAGSAGLGIADQIVNHMVTHGVDKEEARK 414

  Fly   387 KIWFFDANGLV-------------VLGRKDIPEELLEFA--NQRDPILDLVEAIQELKPNILVGG 436
            ||:..|..||:             |..:.|     .|:|  |.|    .|.:.::.:||..|||.
Yeast   415 KIFLMDRRGLILQSYEANSTPAQHVYAKSD-----AEWAGINTR----SLHDVVENVKPTCLVGC 470

  Fly   437 SSLPNTFTPDVLRAMEKSADQPVIFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYANK 501
            |:....||.||:..|.|...:|:||.||.|....|....|...:|..:.:..:||..||:    .
Yeast   471 STQAGAFTQDVVEEMHKHNPRPIIFPLSNPTRLHEAVPADLMKWTNNNALVATGSPFPPV----D 531

  Fly   502 WYQPGHCTSSYLVAGISCGVMLAGFTNIPDEAFCVAAERLASLVWPCDLEKR-NVYPPMRKIQCI 565
            .|:.....:.|...||..|.:|:..|.|.|:....|.::||.|....:.:.| .:.|.:..|...
Yeast   532 GYRISENNNCYSFPGIGLGAVLSRATTITDKMISAAVDQLAELSPLREGDSRPGLLPGLDTITNT 596

  Fly   566 SLQIAEAIFSYAFGRGLATLYPQPENP-----------------MEYIKNSMYNPEYR 606
            |.::|.|:...|...|.|.: .|.:.|                 ::::|..|:.|.||
Yeast   597 SARLATAVILQALEEGTARI-EQEQVPGGAPGETVKVPRDFDECLQWVKAQMWEPVYR 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	156/560 (28%)
		malic	138..317	CDD:278802	55/181 (30%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	77/308 (25%)
MAE1	NP_012896.1	PRK13529	91..658	CDD:237414	161/580 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346253
Domainoid	1	1.000	155	1.000	Domainoid score	I893
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I422
Isobase	1	0.950	-	0	Normalized mean entropy	S996
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
TreeFam	1	0.960	-	-
	9	8.700