DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7848 and NADP-ME4

DIOPT Version :9

Sequence 1:NP_611127.1 Gene:CG7848 / 36839 FlyBaseID:FBgn0034127 Length:633 Species:Drosophila melanogaster
Sequence 2:NP_178093.1 Gene:NADP-ME4 / 844314 AraportID:AT1G79750 Length:646 Species:Arabidopsis thaliana


Alignment Length:552 Identity:193/552 - (34%)
Similarity:308/552 - (55%) Gaps:8/552 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 TFWKMDTRLSGSKVDGLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLES 121
            |.|.:      |...|..:|...::||||||:..||....:.||||..|.:.|.|.:...:.|..
plant    98 TPWSL------SVASGYTLLRDPHHNKGLAFSHRERDAHYLRGLLPPTVISQDLQVKKIMHTLRQ 156

  Fly   122 FTNNVQQYIYLTYLSRRNRRLFYYLLLSNPDRFVPMTDASGSIDLLMVHRMIHSMGQGLYICIKD 186
            :...:|:|:.:..|...|.||||.||:.:.:..:|:.......:....:..|....|||:|.:|:
plant   157 YQVPLQKYMAMMDLQETNERLFYKLLIDHVEELLPVIYTPTVGEACQKYGSIFLRPQGLFISLKE 221

  Fly   187 LGHVSQILSNWPFRCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLD 251
            .|.:.::|.|||.:.::.::|::|..:|.:||||...|.|....|......||:.|:.||.|.:|
plant   222 KGKIHEVLRNWPEKNIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSACLPVTID 286

  Fly   252 VGTNNEELLNDPMYTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELY 316
            ||||||:||||..|.|||:||.:.:.|.:|..||..:|.|.||.:.:|..:||....|...|..|
plant   287 VGTNNEKLLNDEFYIGLRQRRATGEEYSELMHEFMTAVKQNYGEKVVIQFEDFANHNAFDLLAKY 351

  Fly   317 RERQCIVDVDFQCFAAVALAGVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIE 381
            .....:.:.|.|..|:|.|||:|...|......|.:.|||.||.....|:|.|..:.:.::..|.
plant   352 GTTHLVFNDDIQGTASVVLAGLIAALRFVGGSLSDHRFLFLGAGEAGTGIAELIALEISKKSHIP 416

  Fly   382 M-KAREKIWFFDANGLVVLGRKDIPEELLE-FANQRDPILDLVEAIQELKPNILVGGSSLPNTFT 444
            : :||:.||..|:.||:|..||:..:...: :|:..:||.:||:|::.:||.:|:|.|.:..|||
plant   417 LEEARKNIWLVDSKGLIVSSRKESIQHFKKPWAHDHEPIRELVDAVKAIKPTVLIGTSGVGQTFT 481

  Fly   445 PDVLRAMEKSADQPVIFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYANKWYQPGHCT 509
            .||:..|.|..::|:|.:||.|..|:||:||:|:::::|..||.|||...|::|..|.:.||...
plant   482 QDVVETMAKLNEKPIILSLSNPTSQSECTAEEAYTWSQGRAIFASGSPFAPVEYEGKTFVPGQAN 546

  Fly   510 SSYLVAGISCGVMLAGFTNIPDEAFCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIF 574
            ::|:..|...|::::|...:.|:....|:|.||..:.....||..:|||.|.|:.||.:||..:.
plant   547 NAYIFPGFGLGLIMSGTIRVHDDMLLAASEALAEELMEEHYEKGMIYPPFRNIRKISARIAAKVA 611

  Fly   575 SYAFGRGLATLYPQPENPMEYIKNSMYNPEYR 606
            :.|:..||||..|||:...:..::|||:|.||
plant   612 AKAYELGLATRLPQPKELEQCAESSMYSPSYR 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7848NP_611127.1 PLN03129 81..606 CDD:215594 186/526 (35%)
malic 138..317 CDD:278802 65/178 (37%)
NAD_bind_1_malic_enz 327..603 CDD:133454 99/277 (36%)
NADP-ME4NP_178093.1 PLN03129 67..646 CDD:215594 193/552 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 50 1.000 Domainoid score I4360
eggNOG 1 0.900 - - E1_COG0281
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D435571at2759
OrthoFinder 1 1.000 - - FOG0000475
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23406
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X340
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
87.880

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