DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7848 and NADP-ME2

DIOPT Version :9

Sequence 1:	NP_611127.1	Gene:	CG7848 / 36839	FlyBaseID:	FBgn0034127	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_196728.1	Gene:	NADP-ME2 / 831039	AraportID:	AT5G11670	Length:	588	Species:	Arabidopsis thaliana

Alignment Length:	544	Identity:	192/544 - (35%)
Similarity:	297/544 - (54%)	Gaps:	8/544 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SKVDGLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQQYIYL 132
            |...|..::....||||||||..||....:.||||..:.:.|.|.....:.|..:|..:|:|:.|
plant    45 SVASGYTLMRDPRYNKGLAFTDKERDAHYLTGLLPPVILSQDVQERKVMHNLRQYTVPLQRYMAL 109

  Fly   133 TYLSRRNRRLFYYLLLSNPDRFVPMTDASGSIDLLMVHRMIHSMGQGLYICIKDLGHVSQILSNW 197
            ..|..||.||||.||:.|.:..:|:.......:....:..|....|||||.:.:.|.:.::|.||
plant   110 MDLQERNERLFYKLLIDNVEELLPVVYTPTVGEACQKYGSIFRKPQGLYISLNEKGKILEVLKNW 174

  Fly   198 PFRCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNNEELLND 262
            |.|.::.::|::|..:|.:||||...|.|....|......|||.|:.||.:.:|||||||:||||
plant   175 PQRGIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGIRPSACLPITIDVGTNNEKLLND 239

  Fly   263 PMYTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQCIVDVDF 327
            ..|.||::||.:.:.|.:...||..:|.|.||.:.|:..:||....|...|..|.:...:.:.|.
plant   240 EFYIGLKQRRATGQEYAEFLHEFMCAVKQNYGEKVLVQFEDFANHNAFDLLSKYSDSHLVFNDDI 304

  Fly   328 QCFAAVALAGVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKRE-GLIEMKAREKIWFF 391
            |..|:|.|||:|...::.....:.:.|||.||.....|:|.|..:.:.:| |....:.|:|||..
plant   305 QGTASVVLAGLIAAQKVLGKKLADHTFLFLGAGEAGTGIAELIALKISKETGAPITETRKKIWLV 369

  Fly   392 DANGLVVLGRKDIPEELLEF----ANQRDPILDLVEAIQELKPNILVGGSSLPNTFTPDVLRAME 452
            |:.||:|..||   |.|..|    |::..|:.||:.|:..:||.:|:|.|.:..|||.:|:.||.
plant   370 DSKGLIVSSRK---ESLQHFKQPWAHEHKPVKDLIGAVNAIKPTVLIGTSGVGQTFTKEVVEAMA 431

  Fly   453 KSADQPVIFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYANKWYQPGHCTSSYLVAGI 517
            .:.::|:|.|||.|..|.||:||.|:::|||..||.|||...|:.|..|.|.||...:.|:..|:
plant   432 TNNEKPLILALSNPTSQAECTAEQAYTWTKGRAIFGSGSPFDPVVYDGKTYLPGQANNCYIFPGL 496

  Fly   518 SCGVMLAGFTNIPDEAFCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIFSYAFGRGL 582
            ..|::::|...:.|:....|:|.||:.|.........:|||...|:.||..||..:.:..:..||
plant   497 GLGLIMSGAIRVRDDMLLAASEALAAQVTEEHYANGLIYPPFSNIREISANIAACVAAKTYDLGL 561

  Fly   583 ATLYPQPENPMEYIKNSMYNPEYR 606
            |:..|:.::.:::.::|||:|.||
plant   562 ASNLPRAKDLVKFAESSMYSPVYR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	188/529 (36%)
		malic	138..317	CDD:278802	66/178 (37%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	97/280 (35%)
NADP-ME2	NP_196728.1	PLN03129	14..588	CDD:215594	192/544 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I4360
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.880