DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7848 and NAD-ME1

DIOPT Version :9

Sequence 1:	NP_611127.1	Gene:	CG7848 / 36839	FlyBaseID:	FBgn0034127	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_178980.1	Gene:	NAD-ME1 / 815842	AraportID:	AT2G13560	Length:	623	Species:	Arabidopsis thaliana

Alignment Length:	578	Identity:	185/578 - (32%)
Similarity:	304/578 - (52%)	Gaps:	52/578 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLE------------SFTN 124
            ||.:|:...:|||.|||:.||..|.:.||||..|  :|.:.:|...:.:            |..|
plant    46 GLDILHDPWFNKGTAFTMTERNRLDLRGLLPPNV--MDSEQQIFRFMTDLKRLEEQARDGPSDPN 108

  Fly   125 NVQQYIYLTYLSRRNRRLFYYLLLSNPDRFVPM--TDASGSIDLLMVHRMIHSMGQGLYICIKDL 187
            .:.::..|..|..||..::|.:|::|.:.:.|:  |...|.:  ...:..:....:|:|...:|.
plant   109 ALAKWRILNRLHDRNETMYYKVLINNIEEYAPIVYTPTVGLV--CQNYSGLFRRPRGMYFSAEDR 171

  Fly   188 GHVSQILSNWPFRCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDV 252
            |.:..::.|||...|..::|::|:.:|.:|||||..:.|....|...|...||:|...|.||:||
plant   172 GEMMSMVYNWPAEQVDMIVVTDGSRILGLGDLGVHGIGIAVGKLDLYVAAAGINPQRVLPVMIDV 236

  Fly   253 GTNNEELLNDPMYTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYR 317
            |||||:|.|||||.||::||..:..|..:.:||..:|..:: |..::..:||:::.|.|.|:.||
plant   237 GTNNEKLRNDPMYLGLQQRRLEDDDYIDVIDEFMEAVYTRW-PHVIVQFEDFQSKWAFKLLQRYR 300

  Fly   318 ERQCIVDVDFQCFAAVALAGVIVCNRLK---RVFFSSNVFLFYGAEAINIGM---ARLCM--VLL 374
            ....:.:.|.|..|.||:||::...|.:   .:.|.....:..||.:..||:   ||..|  :|.
plant   301 CTYRMFNDDVQGTAGVAIAGLLGAVRAQGRPMIDFPKMKIVVAGAGSAGIGVLNAARKTMARMLG 365

  Fly   375 KREGLIEMKAREKIWFFDANGLVVLGRKDIPEELLEFAN-----QRDPILD---LVEAIQELKPN 431
            ..|...: .|:.:.|..||.||:..||::|..|...||.     :|..:.:   |||.::|:||:
plant   366 NTETAFD-SAQSQFWVVDAQGLITEGRENIDPEAQPFARKTKEMERQGLKEGATLVEVVREVKPD 429

  Fly   432 ILVGGSSLPNTFTPDVLRAMEKS-ADQPVIFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPP 495
            :|:|.|::...|:.:||.||:.| :.:|.|||:|.|.:..||:.:||||....:.||.|||....
plant   430 VLLGLSAVGGLFSKEVLEAMKGSTSTRPAIFAMSNPTKNAECTPQDAFSILGENMIFASGSPFKN 494

  Fly   496 LKYANKWYQPGHC---TSSYLVAGISCGVMLAGFTNIPDEAFCVAAERLASLVWPCDLEKRNVYP 557
            :::.|.  ..|||   .:.||..||..|.:|:|...:.|.....|:|.||:.:...::.:..:||
plant   495 VEFGNG--HVGHCNQGNNMYLFPGIGLGTLLSGAPIVSDGMLQAASECLAAYMSEEEVLEGIIYP 557

  Fly   558 PMRKIQCISLQIAEAIFSYAFGRGLATLYPQ----------PENPMEYIKNSMYNPEY 605
            |:.:|:.|:.:||.|:...|....|...|.:          .|..|||::|:|:||||
plant   558 PISRIRDITKRIAAAVIKEAIEEDLVEGYREMDAREIQKLDEEGLMEYVENNMWNPEY 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	182/569 (32%)
		malic	138..317	CDD:278802	60/180 (33%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	95/305 (31%)
NAD-ME1	NP_178980.1	PLN03129	25..619	CDD:215594	185/578 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780