Protein Alignment CG7848 and ME1

DIOPT Version :10

• Sequence 1: NP_611127.1
• Gene: CG7848 / 36839
• FlyBaseID: FBgn0034127
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_002386.1
• Gene: ME1 / 4199
• HGNCID: 6983
• Length: 572
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 198/545 - (36%)
• Similarity: 309/545 - (56%)
• Gaps: 5/545 - (0%)

  Fly    72 GLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQQYIYLTYLS 136
            |..:....:.||.|||||.||:.|:||||||.:..:.:.|........|...::..:|:.|..|.
Human    15 GYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQ 79

  Fly   137 RRNRRLFYYLLLSNPDRFVPM--TDASGSIDLLMVHRMIHSMGQGLYICIKDLGHVSQILSNWPF 199
            .||.:|||.:|.|:.::|:|:  |...|.  ....:.::....:||:|.|.|.||::.:|:.||.
Human    80 DRNEKLFYRVLTSDIEKFMPIVYTPTVGL--ACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPE 142

  Fly   200 RCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNNEELLNDPM 264
            ..::.::|::|..:|.:||||.:.|.|....|......||::|..||.|:|||||.|||||.||:
Human   143 DVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPL 207

  Fly   265 YTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQCIVDVDFQC 329
            |.|||:||.....||...:||..:|..:||...||..:||....|.:.|..||.:.|..:.|.|.
Human   208 YIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQG 272

  Fly   330 FAAVALAGVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIEMKAREKIWFFDAN 394
            .|:||:||::...|:.:...|....||.||....:|:|.|.::.|::|||.:.||.:|||..|:.
Human   273 TASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSK 337

  Fly   395 GLVVLGRKDIPEELLEFANQRDPILDLVEAIQELKPNILVGGSSLPNTFTPDVLRAMEKSADQPV 459
            ||:|.||..:.:|..:||::.:.:.:|...:||:||..|:|.:::...|:..:|:.|....::|:
Human   338 GLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPI 402

  Fly   460 IFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYAN-KWYQPGHCTSSYLVAGISCGVML 523
            |||||.|..:.|||||..:..|||..||.|||...|:...| :...||...:||:..|::.||:.
Human   403 IFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVA 467

  Fly   524 AGFTNIPDEAFCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIFSYAFGRGLATLYPQ 588
            .|...|.|..|...||.:|..|....||:..:|||:..|:.:||:|||.|...|:....||:||:
Human   468 CGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPE 532

  Fly   589 PENPMEYIKNSMYNPEYRMNIVDVY 613
            |:|...::::.||:.:|...:.|.|
Human   533 PQNKEAFVRSQMYSTDYDQILPDCY 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	194/527 (37%)
ME1	NP_002386.1	PLN03129	11..551	CDD:215594	196/537 (36%)