DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7848 and Me2

DIOPT Version :9

Sequence 1:	NP_611127.1	Gene:	CG7848 / 36839	FlyBaseID:	FBgn0034127	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	XP_006254985.1	Gene:	Me2 / 307270	RGDID:	1310321	Length:	591	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	199/545 - (36%)
Similarity:	304/545 - (55%)	Gaps:	9/545 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 MLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQQYIYLTYLSRRN 139
            |||... |||:||||.||::|.:.||||..:.|.|.||......|:..|:.:::|||:..:..||
  Rat    36 MLNPRT-NKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERN 99

  Fly   140 RRLFYYLLLSNPDRFVPM--TDASGSIDLLMVHRMIHSMGQGLYICIKDLGHVSQILSNWPFRCV 202
            .:|||.:|..:.:..:|:  |...|.......|  |....:||:|.|.|.|||..|:.|||...|
  Rat   100 EKLFYRILQDDIESLMPIVYTPTVGLACCQYGH--IFRRPKGLFISISDRGHVRSIVDNWPENHV 162

  Fly   203 RCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNNEELLNDPMYTG 267
            :.::|::|..:|.:|||||..|.|....|.......||.|..||.|.:||||:|..||.||.|.|
  Rat   163 KAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIQPEKCLPVCIDVGTDNMALLKDPFYMG 227

  Fly   268 LRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQCIVDVDFQCFAA 332
            |.::|...:|||.|.:||..::..:||...||..:||....|.:.|:.|:|:.|..:.|.|..||
  Rat   228 LYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLKKYQEKYCTFNDDIQGTAA 292

  Fly   333 VALAGVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIEMKAREKIWFFDANGLV 397
            |||:|::...|:.....|.:..||.||....:|:|:|.::.:...||.|.:|:.|||.||.|||:
  Rat   293 VALSGLLAAQRVINKPISEHRILFLGAGEAALGIAKLIVISMMESGLSEEEAQRKIWMFDKNGLL 357

  Fly   398 VLGRK---DIPEELLEFANQRDPILDLVEAIQELKPNILVGGSSLPNTFTPDVLRAMEKSADQPV 459
            |.||.   |..:|....|...:......:|:.:|||::::|.:.....|||.|::||....::|:
  Rat   358 VKGRTARIDSNQEPYAHAASENIPATFEDAVNKLKPSVIIGVAGAGPLFTPGVIKAMAAINERPI 422

  Fly   460 IFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYAN-KWYQPGHCTSSYLVAGISCGVML 523
            |||||.|..|.||:||||::.|:|.|:|.|||...|::..: :.:.||...::|:..|::..|:|
  Rat   423 IFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFEPVRLQDGRVFTPGQGNNAYIFPGVALAVIL 487

  Fly   524 AGFTNIPDEAFCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIFSYAFGRGLATLYPQ 588
            ....:|.|..|..||:.|.|.:...:|.:..:||.:..||.:|..||..|..|.:...:|..||:
  Rat   488 CEARHISDTVFLEAAKALTSQLTDEELAQGRLYPSLANIQEVSANIAIKIAEYLYANKMAFRYPE 552

  Fly   589 PENPMEYIKNSMYNPEYRMNIVDVY 613
            ||:..:|:|..::...|...:.|||
  Rat   553 PEDKAKYVKERIWRSNYVSLLPDVY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	192/530 (36%)
		malic	138..317	CDD:278802	68/180 (38%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	97/279 (35%)
Me2	XP_006254985.1	PLN03129	35..573	CDD:215594	196/539 (36%)
		malic	96..277	CDD:278802	68/182 (37%)
		NAD_bind_1_malic_enz	287..565	CDD:133454	97/277 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.710