DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7848 and Me1

DIOPT Version :9

Sequence 1:	NP_611127.1	Gene:	CG7848 / 36839	FlyBaseID:	FBgn0034127	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_036732.3	Gene:	Me1 / 24552	RGDID:	3074	Length:	572	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	196/547 - (35%)
Similarity:	311/547 - (56%)	Gaps:	9/547 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GLWMLNQSNYNKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNL--LESFTNNVQQYIYLTY 134
            |..:....:.||.|||||.||:.|:||||||..:  ::::.::...:  .|...::..:|:.|..
  Rat    15 GYLLTRDPHLNKDLAFTLEERQQLNIHGLLPPCI--VNQEIQVLRVIKNFERLNSDFDRYLLLMD 77

  Fly   135 LSRRNRRLFYYLLLSNPDRFVPM--TDASGSIDLLMVHRMIHSMGQGLYICIKDLGHVSQILSNW 197
            |..||.:|||.:|:||.::|:|:  |...|.  ....:.:.....:||:|.|.|.||::.:|:.|
  Rat    78 LQDRNEKLFYSVLMSNVEKFMPIVYTPTVGL--ACQQYSLAFRKPRGLFISIHDKGHIASVLNAW 140

  Fly   198 PFRCVRCLLVSNGASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNNEELLND 262
            |...|:.::|::|..:|.:||||.:.|.|....|......||::|..||.:.|||||.|||||.|
  Rat   141 PEDVVKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQCLPITLDVGTENEELLKD 205

  Fly   263 PMYTGLRERRCSEKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQCIVDVDF 327
            |:|.|||.||.....||...:||..:...:||...||..:||....|.:.|..||.:.|..:.|.
  Rat   206 PLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANLNAFRLLNKYRNKYCTFNDDI 270

  Fly   328 QCFAAVALAGVIVCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIEMKAREKIWFFD 392
            |..|:||:||::...|:.:...|....||.||....:|:|.|.::.:::|||.:.|||:|||..|
  Rat   271 QGTASVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLIVMAMEKEGLSKEKARQKIWLVD 335

  Fly   393 ANGLVVLGRKDIPEELLEFANQRDPILDLVEAIQELKPNILVGGSSLPNTFTPDVLRAMEKSADQ 457
            :.||:|.||..:.||...||::.:.:.:|...:|::||..|:|.:::...||..:|:.|....::
  Rat   336 SKGLIVKGRASLTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVAAIGGAFTEQILKDMAAFNER 400

  Fly   458 PVIFALSRPLEQTECSAEDAFSYTKGHCIFISGSKLPPLKYAN-KWYQPGHCTSSYLVAGISCGV 521
            |:|||||.|..:.|||||:.:..|||..||.|||...|:...: :...||...:||:..|::.||
  Rat   401 PIIFALSNPTSKAECSAEECYKVTKGRAIFASGSPFDPVTLPDGRTLFPGQGNNSYVFPGVALGV 465

  Fly   522 MLAGFTNIPDEAFCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIFSYAFGRGLATLY 586
            :..|..:|.|..|...||.::..|....||:..:|||:..|:.:||:||..|...|:...:||:|
  Rat   466 VACGLRHINDSVFLTTAEVISQQVSDKHLEEGRLYPPLNTIRDVSLKIAVKIVQDAYKEKMATVY 530

  Fly   587 PQPENPMEYIKNSMYNPEYRMNIVDVY 613
            |:|:|..|::.:.||:..|...:.|.|
  Rat   531 PEPQNKEEFVSSQMYSTNYDQILPDCY 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	192/529 (36%)
		malic	138..317	CDD:278802	68/180 (38%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	100/276 (36%)
Me1	NP_036732.3	PLN03129	11..551	CDD:215594	194/539 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810