DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7848 and me3

DIOPT Version :9

Sequence 1:	NP_611127.1	Gene:	CG7848 / 36839	FlyBaseID:	FBgn0034127	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	XP_031751513.1	Gene:	me3 / 100135099	XenbaseID:	XB-GENE-973120	Length:	624	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	192/535 - (35%)
Similarity:	307/535 - (57%)	Gaps:	5/535 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 NKGLAFTLNERRVLSIHGLLPVAVRTIDEQAEICSNLLESFTNNVQQYIYLTYLSRRNRRLFYYL 146
            |||:||||.||..|.||||||....:.|.|........|:.::::.:||.|..|..||.:|||.:
Frog    80 NKGMAFTLEERLQLGIHGLLPPCFLSQDVQVLRVMKSYETKSSDLDKYIILMTLQDRNEKLFYRV 144

  Fly   147 LLSNPDRFVPM--TDASGSIDLLMVHRMIHSMGQGLYICIKDLGHVSQILSNWPFRCVRCLLVSN 209
            |.|:.:||:|:  |...|.  ....:.:.....:||:|.|.|.||::.:|::||...::.::|::
Frog   145 LTSDIERFMPIVYTPTVGL--ACQQYGLAFRRPRGLFITIHDKGHIATMLNSWPEEDIKAIVVTD 207

  Fly   210 GASVLSVGDLGVDEMPILFSNLHQNVVYGGIHPAYCLAVMLDVGTNNEELLNDPMYTGLRERRCS 274
            |..:|.:||||...|.|....|......||:||..||.|:|||||:||.|||||:|.||:.:|..
Frog   208 GERILGLGDLGGYGMGIPVGKLALYTACGGVHPQQCLPVLLDVGTDNEALLNDPLYIGLKHKRVR 272

  Fly   275 EKLYDQLFEEFTLSVMQQYGPRALILCKDFEAQKAKKQLELYRERQCIVDVDFQCFAAVALAGVI 339
            .|.||:|.:||..:|..:||...||..:||....|.:.|..||.:.|..:.|.|..|:||:||::
Frog   273 GKQYDELIDEFMQAVTNKYGMNCLIQFEDFANSNAFRLLNKYRNKYCTFNDDIQGTASVAVAGIL 337

  Fly   340 VCNRLKRVFFSSNVFLFYGAEAINIGMARLCMVLLKREGLIEMKAREKIWFFDANGLVVLGRKDI 404
            ...|:.....|.:.|:|.||....:|:|:|..:.:::||.....|.:|||..|:.||:|.||.::
Frog   338 AALRITNNRLSDHKFVFQGAGEAAMGIAQLITMAMEKEGTSREDAIKKIWMVDSKGLIVKGRGNL 402

  Fly   405 PEELLEFANQRDPILDLVEAIQELKPNILVGGSSLPNTFTPDVLRAMEKSADQPVIFALSRPLEQ 469
            ..|...||:....:..|.||:|.|||..::|.:::...||..:::.|.....:|:|||||.|..:
Frog   403 NHEKDVFAHDHPQVKTLEEAVQILKPTAIIGVAAIGGAFTEKIIKDMAAFNKRPIIFALSNPTSK 467

  Fly   470 TECSAEDAFSYTKGHCIFISGSKLPPLKYAN-KWYQPGHCTSSYLVAGISCGVMLAGFTNIPDEA 533
            .||:||..:..|:|..||.|||....:..|| :.:.||...::|:..|::.||:..|..:|.::.
Frog   468 AECTAEQCYQLTEGRGIFASGSPFSKVTLANGQTFYPGQGNNAYVFPGVALGVIGCGVRHISEDL 532

  Fly   534 FCVAAERLASLVWPCDLEKRNVYPPMRKIQCISLQIAEAIFSYAFGRGLATLYPQPENPMEYIKN 598
            |...||.:|.:|...:|.:..:|||:..|:.:|.:||..|..||:...:|:.||:||:...::::
Frog   533 FLTTAETIAEMVTAENLAEGRLYPPLSSIRDVSFKIAVKIVDYAYKNNMASWYPEPEDKESFVRS 597

  Fly   599 SMYNPEYRMNIVDVY 613
            .:|:|:|....:|.|
Frog   598 LIYSPDYDSFTIDSY 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7848	NP_611127.1	PLN03129	81..606	CDD:215594	189/526 (36%)
		malic	138..317	CDD:278802	70/180 (39%)
		NAD_bind_1_malic_enz	327..603	CDD:133454	91/276 (33%)
me3	XP_031751513.1	PLN03129	29..608	CDD:215594	190/529 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110