DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6262 and NTH1

DIOPT Version :9

Sequence 1:	NP_611123.2	Gene:	CG6262 / 36833	FlyBaseID:	FBgn0034121	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_010284.1	Gene:	NTH1 / 851564	SGDID:	S000002408	Length:	751	Species:	Saccharomyces cerevisiae

Alignment Length:	630	Identity:	123/630 - (19%)
Similarity:	224/630 - (35%)	Gaps:	174/630 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RGVFCEGPLLDAVQRSKMFPDCKHFVDMSCIFTPAQTLADFDMFTNCRRNDGSLRFLQMFVEKHF 81
            ||.:....||..:..:|.|...:.|:|                  ..|.|:..:..|...:...|
Yeast   147 RGTYMLSNLLQELTIAKSFGRHQIFLD------------------EARINENPVNRLSRLINTQF 193

  Fly    82 ----------------------NDPGSELEH-WTPPDWKAQPSFLARISD--PEIKQFGSDVNGL 121
                                  :.||::... :.|.|...|..|..:.|.  |.:|   .:|..|
Yeast   194 WNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQASQMHPSLK---LEVEYL 255

  Fly   122 WKELGRRIKDEVKENPDQYSII----YVPN---------PFIVPSSNCREYRYWESFWIIRGLLQ 173
            .|::.......|.:.|...::.    :.|:         |:.||.....|...|:|:.:..|||:
Yeast   256 PKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLIGYPYAVPGGRFNELYGWDSYMMALGLLE 320

  Fly   174 CGMHQTARGMIDNYLELVQQYGFVPGCGRIY--C------------------SGRSNPPLLIMMV 218
            ......||||:::::..:..||.:....|.|  |                  .|||||..:.::.
Yeast   321 ANKTDVARGMVEHFIFEINHYGKILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLK 385

  Fly   219 KAYVEVTKDEQYAIEALPLLETE---------------------YDT----FISKHSVQVKGRTM 258
            :|:....|:.:....|.|.|:.|                     :||    :.|||.|     |:
Yeast   386 RAFQASIKEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPYASKHGV-----TL 445

  Fly   259 YQYRDSSAGPRPEAYREDLECVASIKSPVVREVMYTELKSAAESGTNFSSRWYVTVDGSNKGSFR 323
            .:::        :.|.:     ..||.|.:.| .:...:...|||.:.:.|            |.
Yeast   446 DEFK--------QLYND-----GKIKEPKLDE-FFLHDRGVRESGHDTTYR------------FE 484

  Fly   324 DIKTSAIVPVELNCIVFRSGKILAEFNRKAGNTKKADE----------YQDRACVLVKAIRDNLW 378
            .: .:.:..::||.::::....:|:|.::..:.|..|.          :::.|.:..:.|...:|
Yeast   485 GV-CAYLATIDLNSLLYKYEIDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMW 548

  Fly   379 NAQAGIWLDYDLVNNKPRNYFCCTNFAPLWARAFPLVDTEKVSKGVMQYIKTNDLDAQYGGVPYT 443
            :.::|.:.||:.......:|...|.|..|||   .|...|:..|.|.:.:...::   .||:...
Yeast   549 DDESGFFFDYNTKIKHRTSYESATTFWALWA---GLATKEQAQKMVEKALPKLEM---LGGLAAC 607

  Fly   444 MNKESG--------QNWDHPNVFPPMMFLIIEGLENLGTPPAKAMSKRWAHRWVKSNYAAY-KYE 499
            ..:..|        :.||:|..:.|...|..|||.:.|   ...::.|.|:||:.....|: .|.
Yeast   608 TERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYG---YLTVTNRLAYRWLFMMTKAFVDYN 669

  Fly   500 SFMFEKYYC----------EDFGTSGGSSPENTPLGYGWTNGVII 534
            ..:.|||..          .::|..|.........|:||.|...|
Yeast   670 GIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAATEGFGWVNASYI 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6262	NP_611123.2	Trehalase	33..540	CDD:302639	119/614 (19%)
NTH1	NP_010284.1	TreA	88..726	CDD:224541	123/630 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345656
Domainoid	1	1.000	113	1.000	Domainoid score	I1339
eggNOG	1	0.900	-	-		E1_COG1626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I1338
Isobase	1	0.950	-	0	Normalized mean entropy	S2593
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001723
OrthoInspector	1	1.000	-	-		mtm9254
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1112
TreeFam	0	0.000	Not matched by this tool.
	10	9.840