DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6262 and Treh

DIOPT Version :9

Sequence 1:	NP_611123.2	Gene:	CG6262 / 36833	FlyBaseID:	FBgn0034121	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001129613.1	Gene:	Treh / 60576	RGDID:	61831	Length:	576	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	190/546 - (34%)
Similarity:	300/546 - (54%)	Gaps:	17/546 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VFCEGPLLDAVQRSKMFPDCKHFVDMSCIFTPAQTLADFDMFTNCRRNDGSLRFLQMFVEKHFND 83
            ::|.|.||..||.::::.|.|.|||||...:|.:.|..|........:......||.||:.:|..
  Rat    29 IYCHGELLHQVQMAQLYQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIPREELQNFVQSYFQP 93

  Fly    84 PGSELEHWTPPDWKAQPSFLARISDPEIKQFGSDVNGLWKELGRRIKDEVKENPDQYSIIYVPNP 148
            .|.||:.|||.|||..|.||.:|||..::.:..:::.:||:||:::|.||..:|::.|:||..:|
  Rat    94 VGQELQPWTPEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAEVLSHPERSSLIYSEHP 158

  Fly   149 FIVPSSNCREYRYWESFWIIRGLLQCGMHQTARGMIDNYLELVQQYGFVPGCGRIYCSGRSNPPL 213
            ||||.....|:.||:|:|::.|||...|..|.:||:.|:|:||:.||.:|..||:|...||:|||
  Rat   159 FIVPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRVYYLQRSHPPL 223

  Fly   214 LIMMVKAYVEVTKDEQYAIEALPLLETEYDTFISKHSVQV-KGRTMY---QYRDSSAGPRPEAYR 274
            |.:|::.||..|.|..:..|.:..|..|.:.:....:|.| .|...|   :|.....|||||:|.
  Rat   224 LTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYILNRYYVPYGGPRPESYS 288

  Fly   275 EDLECVASIKSPVVREVMYTELKSAAESGTNFSSRWYVTVDGSNKGSFRDIKTSAIVPVELNCIV 339
            :|.|...::... .||.::.|||:.||||.:|||||  .|.|.:......|:||.:||.:||..:
  Rat   289 KDEELAKTVPEG-DRETLWAELKAGAESGWDFSSRW--LVGGPDPDLLSSIRTSKMVPADLNAFL 350

  Fly   340 FRSGKILAEFNRKAGNTKKADEYQDRACVLVKAIRDNLWNAQAGIWLDYDLVNNKPRNYFCCTNF 404
            .::.::::.|..:.||..:|..|::.....:.|:...||:.|.|.|.||||...|....|..:|.
  Rat   351 CQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQKGAWFDYDLEKGKKNLEFYPSNL 415

  Fly   405 APLWARAFPLVDTEKVSKGVMQYIKTNDLDAQYGGVPYTMNKESGQNWDHPNVFPPMMFLIIEGL 469
            .||||..|   ....|:...::|::.|.:.....|:| |..:.:||.||.||.:.|:..|:|.||
  Rat   416 TPLWAGCF---SDPSVADRALKYLEDNKILTYQYGIP-TSLRNTGQQWDFPNAWAPLQDLVIRGL 476

  Fly   470 ENLGTPPAKAMSKRWAHRWVKSNYAAYKYESFMFEKYYCEDFGTSGGSSPENTPLGYGWTNGVII 534
            ....:|..:.::.:.|..|:|:|:..|..:|.|:|||...:.|..||........|:|||||:.:
  Rat   477 AKSASPRTQEVAFQLAQNWIKTNFKVYSQKSAMYEKYDISNGGHPGGGGEYEVQEGFGWTNGLAL 541

  Fly   535 EFLCKYGKEISLADTSDEGSKSKSRG 560
            ..|.:||.:::      .|::..|.|
  Rat   542 MLLDRYGDQLT------SGTQLASLG 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6262	NP_611123.2	Trehalase	33..540	CDD:302639	179/510 (35%)
Treh	NP_001129613.1	TreA	16..551	CDD:224541	187/528 (35%)
Treh	NP_001129613.1	Trehalase	43..547	CDD:279537	179/510 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351163
Domainoid	1	1.000	458	1.000	Domainoid score	I466
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1402
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167279at33208
OrthoFinder	1	1.000	-	-		FOG0001723
OrthoInspector	1	1.000	-	-		otm46225
orthoMCL	1	0.900	-	-		OOG6_102186
Panther	1	1.100	-	-	O	PTHR23403
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900