DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6262 and Treh

DIOPT Version :9

Sequence 1:	NP_611123.2	Gene:	CG6262 / 36833	FlyBaseID:	FBgn0034121	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_726025.1	Gene:	Treh / 45368	FlyBaseID:	FBgn0003748	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	264/530 - (49%)
Similarity:	379/530 - (71%)	Gaps:	3/530 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VFCEGPLLDAVQRS--KMFPDCKHFVDMSCIFTPAQTLADFDMFTNCRRNDGSLRFLQMFVEKHF 81
            ::|||.||..:|.:  |:|.|.|.||||....:|.:||.||:.....:....|...|:.||:|:|
  Fly    55 IYCEGNLLHTIQTAVPKLFADSKTFVDMKLNNSPDKTLEDFNAMMEAKNQTPSSEDLKQFVDKYF 119

  Fly    82 NDPGSELEHWTPPDWKAQPSFLARISDPEIKQFGSDVNGLWKELGRRIKDEVKENPDQYSIIYVP 146
            :.||:|||.|||.|||..||||..||||::||:|.::|.:||:|||::||||.:||:.||||.||
  Fly   120 SAPGTELEKWTPTDWKENPSFLDLISDPDLKQWGVELNSIWKDLGRKMKDEVSKNPEYYSIIPVP 184

  Fly   147 NPFIVPSSNCREYRYWESFWIIRGLLQCGMHQTARGMIDNYLELVQQYGFVPGCGRIYCSGRSNP 211
            ||.|||.....|:.||:|:|||||||...|..||||||:|:..:|.::||:|..||:|..|||.|
  Fly   185 NPVIVPGGRFIEFYYWDSYWIIRGLLYSQMFDTARGMIENFFSIVNRFGFIPNGGRVYYHGRSQP 249

  Fly   212 PLLIMMVKAYVEVTKDEQYAIEALPLLETEYDTFISKHSVQVKGRTMYQYRDSSAGPRPEAYRED 276
            |||..|||:||:.|.|:::||:||..||.|::.|::.|:|.||..::..|||||:|||||:||||
  Fly   250 PLLTGMVKSYVDFTNDDKFAIDALDTLEHEFEFFVNNHNVTVKNHSLCVYRDSSSGPRPESYRED 314

  Fly   277 LECVASIKSPVVREVMYTELKSAAESGTNFSSRWYVTVDGSNKGSFRDIKTSAIVPVELNCIVFR 341
            :|......:...:|:.|:|||:.||||.:|||||:::..|:|.|:...:.|::||||:||..::.
  Fly   315 VETGEEFPTDEAKELHYSELKAGAESGMDFSSRWFISPTGTNDGNRSALSTTSIVPVDLNAYLYW 379

  Fly   342 SGKILAEFNRKAGNTKKADEYQDRACVLVKAIRDNLWNAQAGIWLDYDLVNNKPRNYFCCTNFAP 406
            :.|::|||:.|||||||..||:.:|..|:..|::.|||.:||:|||||::|.|||:|:..||.:|
  Fly   380 NAKLIAEFHSKAGNTKKVTEYETKAEKLLLGIQEVLWNEEAGVWLDYDMINQKPRDYYTPTNLSP 444

  Fly   407 LWARAFPLVDTEKVSKGVMQYIKTNDLDAQYGGVPYTMNKESGQNWDHPNVFPPMMFLIIEGLEN 471
            ||.:||.:.::||:|..||.||:.|.||:..||||.|:: .:|:.||.|||:.||.::::|||.|
  Fly   445 LWVKAFNISESEKISASVMAYIERNKLDSFPGGVPNTLS-YTGEQWDAPNVWAPMQYILVEGLNN 508

  Fly   472 LGTPPAKAMSKRWAHRWVKSNYAAYKYESFMFEKYYCEDFGTSGGSSPENTPLGYGWTNGVIIEF 536
            |.||.||.||.:||.||||:|:||:..:..|:|||..::||..||........|:||:||||||:
  Fly   509 LNTPEAKNMSLKWATRWVKTNFAAFSKDRHMYEKYNADEFGVGGGGGEYEVQTGFGWSNGVIIEW 573

  Fly   537 LCKYGKEISL 546
            |.|:|::||:
  Fly   574 LSKHGRDISI 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6262	NP_611123.2	Trehalase	33..540	CDD:302639	254/506 (50%)
Treh	NP_726025.1	Trehalase	71..577	CDD:279537	254/506 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466543
Domainoid	1	1.000	344	1.000	Domainoid score	I235
eggNOG	1	0.900	-	-		E1_COG1626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167279at33208
OrthoFinder	1	1.000	-	-		FOG0001723
OrthoInspector	1	1.000	-	-		otm26075
orthoMCL	1	0.900	-	-		OOG6_102186
Panther	1	1.100	-	-	P	PTHR23403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1112
	11	10.800