DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6262 and tre-2

DIOPT Version :9

Sequence 1:	NP_611123.2	Gene:	CG6262 / 36833	FlyBaseID:	FBgn0034121	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_501058.2	Gene:	tre-2 / 177451	WormBaseID:	WBGene00006608	Length:	671	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	195/539 - (36%)
Similarity:	295/539 - (54%)	Gaps:	32/539 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VFCEGPLLDAVQRSKMFPDCKHFVDMSCIFTPAQTLADFD--MFTNCRRNDGSLRFLQMFVEKHF 81
            |:|:|.||.|||.|.:|||||.||||........|||.::  |......||    .|.:|:.::|
Worm    92 VWCDGTLLHAVQLSGLFPDCKTFVDMPLKHDADVTLARWNALMALAPITND----VLALFLRENF 152

  Fly    82 NDPGSELEHWTPPDWKAQPSFLARISDPEIKQFGSDVNGLWKELGRRIKDEVKENPDQYSIIYVP 146
            ::|..|||...|.||.........|.|.:.::|.:.::..|..|.|:|..:|:.||::||||.||
Worm   153 DEPEGELEECAPTDWAPMTDQFGGIIDEDYRRFAAALHAKWPTLYRKISKKVRVNPEKYSIIPVP 217

  Fly   147 NPFIVPSSNCREYRYWESFWIIRGLLQCGMHQTARGMIDNYLELVQQYGFVPGCGRIYCSGRSNP 211
            |||:||....||..||:||:.|:||:..||..|.:|||:|.:.||:.|||:|...|:|...||.|
Worm   218 NPFVVPGGRFREMYYWDSFFTIKGLIASGMLTTVKGMIENMIYLVETYGFIPNGTRVYYLNRSQP 282

  Fly   212 PLLIMMVKAYVEVTKDEQYAIEALPLLETEYDTFISKHSVQVK---GRTMYQYRDSSAGPRPEAY 273
            |||...||||.|.|.|:|:..:.||.|..|: :|...|.....   ...:|::...::.||||:|
Worm   283 PLLTWCVKAYYEATGDKQFLSDVLPTLRKEF-SFFQTHKTYNHPDWNTPLYRFVVETSHPRPESY 346

  Fly   274 REDLECVASIKSPVVREVMYTELKSAAESGTNFSSRWYVTVDGSNKGSFRDIKTSAIVPVELNCI 338
            |||||....:.:...:.|::.:|.:|||||.:||||:: .|.|...|.....:||.::||:||.|
Worm   347 REDLESAEHLDTLEKKCVLWGDLAAAAESGRDFSSRFF-AVHGPYAGQLASTRTSQLIPVDLNSI 410

  Fly   339 VFRSGKILAEFNRKAGNTKKADEYQDRACVLVKAIRDNLWNAQAGIWLDYDLVNNKPRNYFCCTN 403
            :..:.|.|:|.....|:.:.|..:.:....|...||..|||.:...|.|:|:........|..||
Worm   411 ICGNMKTLSEMYTVCGDLESAKYFDNEYRTLRDTIRQVLWNEEHNCWFDFDVEEGNHATSFHDTN 475

  Fly   404 FAPLWARAFPLVDTEKVSKGVMQYIKTNDLDAQYGGVPYTMNKESGQNWDHPNVFPPMMFLIIEG 468
            |.|::..::   ..:..|:.|:.|:.|:...:..||:|.:: ..||:.||.||.:||..::::||
Worm   476 FFPMYCDSY---HEDLDSQVVVDYLTTSGAISFPGGIPVSL-VNSGEQWDFPNSWPPTTWVLLEG 536

  Fly   469 LENLGTPPAKAMSKRWAHRWVKSNYAAYKYE-SFMFEKYY----CEDFGTSGGSS---PENTPLG 525
            |..:|   .:.::.....:||:.|:..::.. ..|||||.    |  |...||..   .|    |
Worm   537 LRKVG---QEELALSLVEKWVQKNFNMWRTSGGRMFEKYNVVSPC--FKVKGGGEYVMQE----G 592

  Fly   526 YGWTNGVIIEFLCKYGKEI 544
            :|||||||::||..||.:|
Worm   593 FGWTNGVILDFLKNYGSKI 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6262	NP_611123.2	Trehalase	33..540	CDD:302639	183/519 (35%)
tre-2	NP_501058.2	Trehalase	107..607	CDD:279537	183/518 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2593
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167279at33208
OrthoFinder	1	1.000	-	-		FOG0001723
OrthoInspector	1	1.000	-	-		mtm4797
orthoMCL	1	0.900	-	-		OOG6_102186
Panther	1	1.100	-	-	O	PTHR23403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.660