Protein Alignment CG6262 and TREH

DIOPT Version :10

• Sequence 1: NP_611123.2
• Gene: CG6262 / 36833
• FlyBaseID: FBgn0034121
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_009111.2
• Gene: TREH / 11181
• HGNCID: 12266
• Length: 583
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 193/531 - (36%)
• Similarity: 298/531 - (56%)
• Gaps: 11/531 - (2%)

  Fly    19 VFCEGPLLDAVQRSKMFPDCKHFVDMSCIFTPAQTLADFDMFTNCRRNDGSLRFLQMFVEKHFND 83
            ::|.|.||:.||.:|::.|.|.||||.....|.|.|..|...:....:......||.||.:||..
Human    32 IYCHGELLNQVQMAKLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQA 96

  Fly    84 PGSELEHWTPPDWKAQPSFLARISDPEIKQFGSDVNGLWKELGRRIKDEVKENPDQYSIIYVPNP 148
            .|.||:.|||.|||..|.||.:|||.:::.:...::.|||:||:::|.||..:|:::|:||..:|
Human    97 KGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHP 161

  Fly   149 FIVPSSNCREYRYWESFWIIRGLLQCGMHQTARGMIDNYLELVQQYGFVPGCGRIYCSGRSNPPL 213
            ||||.....|:.||:|:|::.|||...|.:|.:||:.|:|:||:.||.||..||:|...||.|||
Human   162 FIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPL 226

  Fly   214 LIMMVKAYVEVTKDEQYAIEALPLLETEYDTFISKHSVQV----KGRTMYQYRDSSAGPRPEAYR 274
            |.:|:..|:..|.|..:..|.:..|..|.|.:....:|.|    |...:.:|.....|||||:|.
Human   227 LTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYS 291

  Fly   275 EDLECVASIKSPVVREVMYTELKSAAESGTNFSSRWYVTVDGSNKGSFRDIKTSAIVPVELNCIV 339
            :|:| :|.......||.::.|||:.||||.:|||||  .:.|.|..|...|:||.:|||:||..:
Human   292 KDVE-LADTLPEGDREALWAELKAGAESGWDFSSRW--LIGGPNPNSLSGIRTSKLVPVDLNAFL 353

  Fly   340 FRSGKILAEFNRKAGNTKKADEYQDRACVLVKAIRDNLWNAQAGIWLDYDLVNNKPRNYFCCTNF 404
            .::.::::.|..:.||..:|.:|:......:.|:...||:.|.|.|.||||...|....|..:|.
Human   354 CQAEELMSNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNL 418

  Fly   405 APLWARAFPLVDTEKVSKGVMQYIKTNDLDAQYGGVPYTMNKESGQNWDHPNVFPPMMFLIIEGL 469
            .||||..|   ....|:...::|::.|.:.....|:|.::.| :||.||.||.:.|:..|:|.||
Human   419 TPLWAGCF---SDPGVADKALKYLEDNRILTYQYGIPTSLQK-TGQQWDFPNAWAPLQDLVIRGL 479

  Fly   470 ENLGTPPAKAMSKRWAHRWVKSNYAAYKYESFMFEKYYCEDFGTSGGSSPENTPLGYGWTNGVII 534
            .......|:.::.:.|..|:::|:..|..:|.|:|||...:.|..||........|:||||||::
Human   480 AKAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWTNGVVL 544

  Fly   535 EFLCKYGKEIS 545
            ..|.:||..::
Human   545 MLLDRYGDRLT 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6262	NP_611123.2	Trehalase	33..541	CDD:418443	185/511 (36%)
TREH	NP_009111.2	Trehalase	46..551	CDD:395961	185/511 (36%)