DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wcd and utp18

DIOPT Version :9

Sequence 1:	NP_611121.1	Gene:	wcd / 36831	FlyBaseID:	FBgn0262560	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_012827232.2	Gene:	utp18 / 549389	XenbaseID:	XB-GENE-981919	Length:	522	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	148/510 - (29%)
Similarity:	264/510 - (51%)	Gaps:	39/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QQEQEKPAKIKRERYIPKASQAKELNYVEVPMEKVLFGDRQRLLTNL---AKS----VGQKLPND 79
            |::..|..:..|.:::...:...|.:.:   :|:::||.....:..|   :|:    .|..|.:|
Frog    27 QEQNMKEEEELRTKHLKALADKPETDTI---LEELVFGGEDEFVEKLIGHSKARHTVSGDLLESD 88

  Fly    80 DEDEQEENPGQAKPGDKRKAAWSDSDD---EDLQV-----GDVKKATKHTGPLNHLRKDKSYKEY 136
            .|:|..||....    .||.||.|.:|   |::::     .|:.|:...|.    |.|:| .:..
Frog    89 SEEETSENAAPL----ARKPAWVDEEDEHEENIEMTHRYRKDIMKSKTETA----LSKEK-LQAR 144

  Fly   137 LTARFQRTL-NQPKWA----EKKVKNEDDE-DVSSDEELLRTVGFIDRKARNSDLPQKTLNFKRV 195
            |..:||:.: ..|.||    :|::..||:| :..:|:.||...|  :..:::|.|.:..:..::.
Frog   145 LQEQFQKAMGGVPSWACQGSKKRISKEDEESEEENDDNLLSKTG--NLLSQSSYLSKGVIQIRKC 207

  Fly   196 KDLNRATYAEGNATSIQFHPTSTAALVAGMNGLATIYAVDGQKNERLHNMRFKKFPLACSRIAPC 260
            .:.|....:....|::||||.:...:.||.:...:::.|||::|:::.::..:|||:..::.:..
Frog   208 INANHERLSRVPLTTVQFHPLAQVVMTAGFDRSVSLFQVDGKRNQKIQSIHLEKFPIYKAQFSAD 272

  Fly   261 GTRAF-FGSVKPFYYSYDLLEAKESKL-KLPGAME-FMHRFEVSPCGKFIVTAGKFGAIHLLTAK 322
            |.:.. .|.....:|.||::......: ::.|..| .:.:|||||.|.|::..|..|.:|||:.|
Frog   273 GEQVIATGLRSKMFYIYDMMGGNIITVPRIRGLEERVIQQFEVSPNGSFLLLNGSAGYLHLLSMK 337

  Fly   323 TNELLHSFKQEGKVKGFTWSSDSKRILVCGSTSNVSVLNLRQNLIEHIFMDDGCIHGESIQLSPN 387
            |.||:.|.|..||.....:|.||.::........|.|.::|.....:.|.|:|.|.|.||.||.:
Frog   338 TKELIGSMKMNGKSMKAVFSPDSSKVFSNSDDGFVYVWDVRSRQCLNKFTDEGSICGTSIALSRD 402

  Fly   388 QRLLATGSQEGVVNIYDYESIFASKAPQPEKRFMNLRTAITDLQFNHSSELLAMCSSEAPNAFKL 452
            .|.::.||..||||||::|.......|:|.|..|||.|:.:.:.||..:|::|:.|::..:|.||
Frog   403 GRYISCGSNSGVVNIYNHEDCLQQTNPRPLKAIMNLVTSASSIIFNPQTEIMAVASNKTDDAVKL 467

  Fly   453 AHFPSATVYSNFPAQNEK-VGFVTSMAFSPHSSFLAFATKGKQVPLFRLKYFKGY 506
            .|.||.:|:||||.||:| :....:|.|||.|.:.:.|....:..|:|||::..:
Frog   468 VHIPSFSVFSNFPGQNKKSIHLPRAMDFSPRSGYFSIANNKGEALLYRLKHYSDF 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wcd	NP_611121.1	WD40	<131..444	CDD:225201	95/321 (30%)
		WD40 repeat	209..247	CDD:293791	11/37 (30%)
		WD40	296..>504	CDD:295369	81/208 (39%)
		WD40 repeat	298..332	CDD:293791	17/33 (52%)
		WD40 repeat	337..371	CDD:293791	6/33 (18%)
		WD40 repeat	376..415	CDD:293791	16/38 (42%)
		WD40 repeat	428..465	CDD:293791	14/36 (39%)
utp18	XP_012827232.2	WD40	197..520	CDD:225201	104/322 (32%)
		WD40 repeat	220..260	CDD:293791	11/39 (28%)
		WD40 repeat	265..304	CDD:293791	5/38 (13%)
		WD40 repeat	309..345	CDD:293791	16/35 (46%)
		WD40 repeat	352..387	CDD:293791	6/34 (18%)
		WD40 repeat	394..436	CDD:293791	18/41 (44%)
		WD40 repeat	442..480	CDD:293791	14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5924
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41087
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D462558at2759
OrthoFinder	1	1.000	-	-		FOG0004465
OrthoInspector	1	1.000	-	-		oto104403
Panther	1	1.100	-	-	LDO	PTHR18359
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1617
SonicParanoid	1	1.000	-	-		X4897
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190