DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wcd and B0280.9

DIOPT Version :9

Sequence 1:	NP_611121.1	Gene:	wcd / 36831	FlyBaseID:	FBgn0262560	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_498555.1	Gene:	B0280.9 / 175994	WormBaseID:	WBGene00015104	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	126/437 - (28%)
Similarity:	206/437 - (47%)	Gaps:	40/437 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DKRKAAWSDSDDEDLQVGDVKKA-------TKHTGPLNHLRKDKSYKEYLTARFQRTLNQ----- 147
            :..|.||.|.||:::.|...||.       .|.|....|...|.  |||: .|.|....:
Worm     8 ESEKPAWHDEDDDNMVVAVPKKVKMTMRVELKRTTDEEHGELDS--KEYV-GRLQEAFRKRHGGT 69

  Fly   148 PKWAEKKVKNEDDEDVSSDEELLRT-VGFIDRKARNSDLPQKTLNFKRVKDLNRA-TYAEGNATS 210
            ||||  |....|:|:.|    ||:| .|::   |::.:||:.|::...:||.|.. .|..| .|.
Worm    70 PKWA--KAAAGDEEEGS----LLKTAAGYL---AKDVNLPKTTIHTTLIKDFNIGHRYTRG-ITV 124

  Fly   211 IQFHPTSTAALVAGMNGLATIYAV--DGQKNERLHNMRFKKFPLACSRIAPCGTRAFFGSVKPFY 273
            ::||.|....:||...|...::.|  :.:|:..|.:..|.|||:....||..|......|.:..|
Worm   125 VKFHKTRPVLIVADQGGNVQLFKVSREVKKDRFLQSANFSKFPIDSLEIADKGHSVICSSSRKEY 189

  Fly   274 YSYDLLEAKE-SKLKLPGAM--EFMHRFEVSPCGKFIVTAGKFGAIHLLTAKTNELLHSFK---Q 332
            .....:|.:| ::||.|..:  :.:..|.:|...:|:..||....|::|.|.:.|.:.:..   .
Worm   190 LMQYNMETREVTQLKPPNTVPKQGIRLFAISHDSQFLAIAGHNSHIYVLHATSMEHITTISLPAN 254

  Fly   333 EGKVKGFTWSSDSKRILVCGSTSNVSVLNL---RQNLIEHIFMDDGCIHGESIQLSPNQRLLATG 394
            ..::|.|  .|.|:.|.:...|..:.:.|:   .....:|.|.|||.:||.::.:|.:....|||
Worm   255 ASEIKFF--PSHSREIWIICETGQIVIANIGLPGTKSSQHTFTDDGAVHGTTLAISQHGDYFATG 317

  Fly   395 SQEGVVNIYDYESIFASKAPQPEKRFMNLRTAITDLQFNHSSELLAMCSSEAPNAFKLAHFPSAT 459
            |..|:||:|.......|..|:|.....||.||::.:.||..::|:|:||:...|..:|.|..|.|
Worm   318 SDTGIVNVYSGNDCRNSTNPRPLFNVSNLVTAVSSIAFNSDAQLMAICSNVKDNHLRLVHVASQT 382

  Fly   460 VYSNFPAQNEKVGFVTSMAFSPHSSFLAFATKGKQVPLFRLKYFKGY 506
            .:.|||.:|.||.....:.|||:..::|......::.:|.:.:|..|
Worm   383 TFKNFPERNGKVTHARCVEFSPNGGYMAVGNDDGRLHVFEIHHFTDY 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wcd	NP_611121.1	WD40	<131..444	CDD:225201	94/330 (28%)
		WD40 repeat	209..247	CDD:293791	10/39 (26%)
		WD40	296..>504	CDD:295369	61/213 (29%)
		WD40 repeat	298..332	CDD:293791	9/36 (25%)
		WD40 repeat	337..371	CDD:293791	8/36 (22%)
		WD40 repeat	376..415	CDD:293791	12/38 (32%)
		WD40 repeat	428..465	CDD:293791	12/36 (33%)
B0280.9	NP_498555.1	WD40	<66..424	CDD:225201	106/369 (29%)
		WD40 repeat	122..195	CDD:293791	19/72 (26%)
		WD40	167..423	CDD:295369	72/257 (28%)
		WD40 repeat	168..207	CDD:293791	9/38 (24%)
		WD40 repeat	201..251	CDD:293791	12/49 (24%)
		WD40 repeat	258..296	CDD:293791	9/39 (23%)
		WD40 repeat	303..343	CDD:293791	12/39 (31%)
		WD40 repeat	350..388	CDD:293791	12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156086
Domainoid	1	1.000	146	1.000	Domainoid score	I2820
eggNOG	1	0.900	-	-		E1_KOG2055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I2863
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55114
OrthoDB	1	1.010	-	-		D462558at2759
OrthoFinder	1	1.000	-	-		FOG0004465
OrthoInspector	1	1.000	-	-		oto19217
orthoMCL	1	0.900	-	-		OOG6_102672
Panther	1	1.100	-	-	LDO	PTHR18359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1617
SonicParanoid	1	1.000	-	-		X4897
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800