DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup62 and NUP100

DIOPT Version :9

Sequence 1:	NP_001286489.1	Gene:	Nup62 / 36830	FlyBaseID:	FBgn0034118	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_012855.1	Gene:	NUP100 / 853796	SGDID:	S000001551	Length:	959	Species:	Saccharomyces cerevisiae

Alignment Length:	502	Identity:	113/502 - (22%)
Similarity:	169/502 - (33%)	Gaps:	154/502 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AAPTGGATSSFSFGLSTGTPAAAPASGAATTAPATKTTFS------FG-TPAPTAGIGGGDADNS 67
            |.|.|  |:...||   |..:..|.|...||...|..|.|      || |.......||....|.
Yeast   397 AKPAG--TTGSLFG---GNSSTQPNSLFGTTNVPTSNTQSQQGNSLFGATKLTNMPFGGNPTANQ 456

  Fly    68 KAQAPPAFG----------FGLGSGTASAPLTLGTQAAANPASTTSATATG------TSAAPPAF 116
            .......||          ||..:.:.:.|.|.|. ...|..::||.|.||      .|.:.||.
Yeast   457 SGSGNSLFGTKPASTTGSLFGNNTASTTVPSTNGL-FGNNANNSTSTTNTGLFGAKPDSQSKPAL 520

  Fly   117 GGFTAQPAASVVPTIATSAPNTAATT--TGLLGGSGLGAPKTTAAAST---------TLTA---- 166
            ||.....:.|...||..:.|....||  |||.|.:|   ..::|..||         ||..
Yeast   521 GGGLFGNSNSNSSTIGQNKPVFGGTTQNTGLFGATG---TNSSAVGSTGKLFGQNNNTLNVGTQN 582

  Fly   167 APSAIASTQ----GAAPAPTLSTGGA-----FA------NLTTETKTTDS---------SAVSTA 207
            .|....:||    |....|:|.....     |:      ::|...|.|.|         |::::|
Yeast   583 VPPVNNTTQNALLGTTAVPSLQQAPVTNEQLFSKISIPNSITNPVKATTSKVNADMKRNSSLTSA 647

  Fly   208 SQLSYHQL-------EEHINKW--TLEFEEQ-----EKVFTEQATQINAWD-----------KLL 247
            .:|:...|       :....||  |||..::     ..:...:::.:|:.|           .|:
Yeast   648 YRLAPKPLFAPSSNGDAKFQKWGKTLERSDRGSSTSNSITDPESSYLNSNDLLFDPDRRYLKHLV 712

  Fly   248 ISNNGKIVELN---DAVKKVK----TDQQVL--DQELEFIA---------TQQKELEDSLGPLEK 294
            |.||..:..:|   |...|||    |.:...  ||....||         :.|.:|:|.    ..
Yeast   713 IKNNKNLNVINHNDDEASKVKLVTFTTESASKDDQASSSIAASKLTEKAHSPQTDLKDD----HD 773

  Fly   295 EFVNLPRVDMERSQTYL-MVENLDTQLKQMSEDLKEIIDNLNEANKGQDTTDP---------IIQ 349
            |....|:.......|.: |:||     :::|..:..::.|.....|......|         :|:
Yeast   774 ESTPDPQSKSPNGSTSIPMIEN-----EKISSKVPGLLSNDVTFFKNNYYISPSIETLGNKSLIE 833

  Fly   350 IGKILN---AHMNSLQWIESQSTNISKKLEDIGKIQDSQKRDIFRAP 393
            :.||.|   .|.|                  .||::..:..|:...|
Yeast   834 LRKINNLVIGHRN------------------YGKVEFLEPVDLLNTP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup62	NP_001286489.1	Nsp1_C	194..300	CDD:309972	32/157 (20%)
Nup62	NP_001286489.1	SMC_N	<213..392	CDD:330553	44/234 (19%)
NUP100	NP_012855.1	Nucleoporin_FG2	54..>246	CDD:406391
		ser_rich_anae_1	<290..>566	CDD:411418	51/177 (29%)
		Nucleoporin_FG	429..509	CDD:404514	21/80 (26%)
		Nucleoporin2	814..955	CDD:397975	12/67 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030