DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup62 and NSP1

DIOPT Version :9

Sequence 1:	NP_001286489.1	Gene:	Nup62 / 36830	FlyBaseID:	FBgn0034118	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_012494.3	Gene:	NSP1 / 853409	SGDID:	S000003577	Length:	823	Species:	Saccharomyces cerevisiae

Alignment Length:	496	Identity:	128/496 - (25%)
Similarity:	192/496 - (38%)	Gaps:	131/496 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FQLPTTTAAPTGGATS--SFSFGLSTGT----PAAAPA----------SGAATTAPA-------- 43
            |......|......||  :||||..:..    .|:.||          ..:||:.||
Yeast   341 FSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKPDENKASATSKPAFSFGAKPE 405

  Fly    44 -------TKTTFSF----------GTPAPTAGIGGGDAD-NSKAQAPPAFGFGLGS-----GTAS 85
                   :|..|||          ||..|....|...|: |:...:.|||.||..|     |.||
Yeast   406 EKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDAS 470

  Fly    86 AP--------------------LTLGTQAAANPASTTSATATGTSAAP----------PAFGGFT 120
            .|                    .:.||::.....|.:|..|....|.|          ||| .|.
Yeast   471 KPAFSFGAKSDEKKDSDSSKPAFSFGTKSNEKKDSGSSKPAFSFGAKPDEKKNDEVSKPAF-SFG 534

  Fly   121 AQPAASVVPTIATSAPNTAATTTGLLGGSGLGAPKTTAAASTTLTAAPSAIASTQGAAPAPTL-- 183
            |:.........:.||.:..:..||...|.|       |.|:.:..|.|....|:..:.||.|.
Yeast   535 AKANEKKESDESKSAFSFGSKPTGKEEGDG-------AKAAISFGAKPEEQKSSDTSKPAFTFGA 592

  Fly   184 -----------STGGAFANLTTETKTTDSSAVSTAS------QLSYHQLEEHINKWTLEFEEQEK 231
                       |||.:    |.:.|::||..:::..      .|....|::.:.|||.:..|...
Yeast   593 QKDNEKKTEESSTGKS----TADVKSSDSLKLNSKPVELKPVSLDNKTLDDLVTKWTNQLTESAS 653

  Fly   232 VFTEQATQINAWDKLLISNNGKIVEL-NDAVKKVKTDQQVLDQELEFIATQQKELEDSLGPLE-K 294
            .|.:...:||:||::|:....:|.:| :||| ..:..|..:||.|::|..||.|||:.|...| |
Yeast   654 HFEQYTKKINSWDQVLVKGGEQISQLYSDAV-MAEHSQNKIDQSLQYIERQQDELENFLDNFETK 717

  Fly   295 EFVNLPRV------------DMERSQTYLMVENLDTQLKQMSEDLKEIIDNLNE-ANKGQDTT-- 344
            ....|..|            |.:|.|.|...:.||..|..:|.:|..:|..:|. :|....||
Yeast   718 TEALLSDVVSTSSGAAANNNDQKRQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTTNI 782

  Fly   345 -----DPIIQIGKILNAHMNSLQWIESQSTNISKKLEDIGK 380
                 |..||:.||||:|.::|:.::..||::.|::..|.|
Yeast   783 DINNEDENIQLIKILNSHFDALRSLDDNSTSLEKQINSIKK 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup62	NP_001286489.1	Nsp1_C	194..300	CDD:309972	33/113 (29%)
Nup62	NP_001286489.1	SMC_N	<213..392	CDD:330553	59/190 (31%)
NSP1	NP_012494.3	PHA03255	61..>214	CDD:165513
		PTZ00121	<289..>602	CDD:173412	61/268 (23%)
		Nsp1_C	620..731	CDD:398645	32/111 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345849
Domainoid	1	1.000	53	1.000	Domainoid score	I2824
eggNOG	1	0.900	-	-		E1_KOG2196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58970
OrthoFinder	1	1.000	-	-		FOG0002862
OrthoInspector	1	1.000	-	-		oto100136
orthoMCL	1	0.900	-	-		OOG6_102783
Panther	1	1.100	-	-	LDO	PTHR12084
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.780