DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup62 and Nupl1

DIOPT Version :9

Sequence 1:	NP_001286489.1	Gene:	Nup62 / 36830	FlyBaseID:	FBgn0034118	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_733479.1	Gene:	Nupl1 / 71844	MGIID:	1919094	Length:	587	Species:	Mus musculus

Alignment Length:	475	Identity:	111/475 - (23%)
Similarity:	179/475 - (37%)	Gaps:	151/475 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LPTTTAAPTG-GATSSFSFGLSTGTPAAAPASGAATTAPATKTTF-SFG---TPAPTAGIGGGDA 64
            |.:||.||.| ||.|.||||.            .|::.|:....| |.|   |||.|:...||
Mouse    12 LGSTTVAPGGTGAGSGFSFGT------------VASSTPSVGLNFGSLGSSVTPASTSASAGG-- 62

  Fly    65 DNSKAQAPPAFGFGLGSGTASAPLTLGTQAAANPASTTSATATGTSAAPPAFGGFTAQPAASVVP 129
                      ||.||.....:...||| ..:|..|:||||:.||.|.      || ::||||..|
Mouse    63 ----------FGTGLFGSKPATGFTLG-GTSAGTAATTSASTTGFSL------GF-SKPAASATP 109

  Fly   130 -------------TIATSAPNTAATTTGLLGGSGLGA-PKTTAAASTTL---------------- 164
                         |::::..:|.|.:||.. .:.||| |.||..|||.|
Mouse   110 FALPVTSTSASGLTLSSALTSTPAASTGFT-LNNLGATPATTTTASTGLSLGGALAGLGGSLFQS 173

  Fly   165 ------------------TAAPSAIASTQGAAPAPTLSTGGAFANLTTETKTTDSSAVSTAS-QL 210
                              |.||::.||.:|.. ....||.....:..|.|:..||.|:...: ..
Mouse   174 GNTATSGLGQNALSLSLGTTAPTSAASNEGLG-GIDFSTSSDKKSDKTGTRPEDSKALKDENLPP 237

  Fly   211 SYHQLEEHINKWTLEFEEQEKVFTEQATQINAWDKLLISNNGKIVELNDAVKKVKTDQQVLDQEL 275
            ...|..|::.|    |.:::|...|:.::::                :.|:.||:.|.:.|.|.|
Mouse   238 VICQDVENLQK----FVKEQKQVQEEISRMS----------------SKAMLKVQEDIKALKQLL 282

  Fly   276 EFIATQQKELEDSLGPLEKEFVNLPRVDMERSQTY----------------------------LM 312
            ...|:          .|::..:|:.::.:|.:|..                            ::
Mouse   283 SLAAS----------GLQRNTLNIDKLKLETAQELKNAEIALRTQKTPPGLQHENTAPADYFRIL 337

  Fly   313 VENLDTQLKQMSEDLKEIIDNL-----NEANKGQDTTDPIIQIGKILNAHMNSLQWIESQSTNIS 372
            |:..:.||:|..:.::|:.::|     |.....||.:..:.:|.:...|....||.|......:.
Mouse   338 VQQFEVQLQQYRQQIEELENHLATQASNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLK 402

  Fly   373 KKLEDIGKIQDSQKRDIFRA 392
            ::.....|:......|:|.|
Mouse   403 EQYLGYRKMFLGDAVDVFEA 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup62	NP_001286489.1	Nsp1_C	194..300	CDD:309972	21/106 (20%)
Nup62	NP_001286489.1	SMC_N	<213..392	CDD:330553	35/211 (17%)
Nupl1	NP_733479.1	14 X 2 AA repeats of F-G	7..567		111/475 (23%)
		Nucleoporin_FG2	22..587	CDD:292589	105/465 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..236		10/40 (25%)
		OEP	278..424	CDD:280481	26/155 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940