DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7997 and GLA

DIOPT Version :9

Sequence 1:	NP_611119.1	Gene:	CG7997 / 36829	FlyBaseID:	FBgn0034117	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_000160.1	Gene:	GLA / 2717	HGNCID:	4296	Length:	429	Species:	Homo sapiens

Alignment Length:	411	Identity:	191/411 - (46%)
Similarity:	268/411 - (65%)	Gaps:	20/411 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LGGILLLQVLQL-------SMGLDNGLALKPPMGWMSWERFRCITDCKLYPDECISEKLFQRHAD 66
            ||..|.|:.|.|       :..||||||..|.|||:.||||.|..||:..||.|||||||...|:
Human    10 LGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAE 74

  Fly    67 LLVSEGYADAGYEYVIIDDCWLEKNRDNDTQKLVPDRKRFPNGLNALSDHIHNQGLKFGLYQDYG 131
            |:||||:.||||||:.|||||:...||:: .:|..|.:|||:|:..|::::|::|||.|:|.|.|
Human    75 LMVSEGWKDAGYEYLCIDDCWMAPQRDSE-GRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVG 138

  Fly   132 TNTCAGYPGVIKHMKLDAQTFADWDVDYVKLDGCYA-NISDMASGYPEFGRLLNETGRPMVYSCS 195
            ..||||:||...:..:||||||||.||.:|.||||. ::.::|.||......||.|||.:||||.
Human   139 NKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCE 203

  Fly   196 WPAYQEDAGEMPDYESLKQHCNLWRNWDDIEDSLESLMQIIDYFAKNQDRIQPHGGPGHWNDPDM 260
            ||.|.... :.|:|..::|:||.|||:.||:||.:|:..|:|:.:.||:||....|||.||||||
Human   204 WPLYMWPF-QKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDM 267

  Fly   261 LLLGNYGLSYDQSKLQMAIWAIMAAPLIMSNDLAAVRPEIKAILQNRAVIAVDQDELGIQGRRVL 325
            |::||:|||::|...|||:||||||||.|||||..:.|:.||:||::.|||::||.||.||.::.
Human   268 LVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLR 332

  Fly   326 SRNQIEVWKRPITPVTKSGHHSYAVAFVSRRDDGAPYRIPFTVKELG---LTNPKGYNVQDLYDA 387
            ..:..|||:||::.:      ::|||.::|::.|.|......|..||   ..||..: :..|...
Human   333 QGDNFEVWERPLSGL------AWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACF-ITQLLPV 390

  Fly   388 SSKLGVFQSESQFITRVNPNG 408
            ..|||.::..|:..:.:||.|
Human   391 KRKLGFYEWTSRLRSHINPTG 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7997	NP_611119.1	AmyAc_family	31..408	CDD:298606	178/380 (47%)
GLA	NP_000160.1	Melibiase_2	39..411	CDD:293108	178/380 (47%)
GLA	NP_000160.1	Substrate binding	203..207		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90852
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62673
OrthoDB	1	1.010	-	-		D266390at33208
OrthoFinder	1	1.000	-	-		FOG0001285
OrthoInspector	1	1.000	-	-		otm40912
orthoMCL	1	0.900	-	-		OOG6_101043
Panther	1	1.100	-	-	O	PTHR11452
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R31
SonicParanoid	1	1.000	-	-		X887
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.750