DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7997 and gla

DIOPT Version :9

Sequence 1:	NP_611119.1	Gene:	CG7997 / 36829	FlyBaseID:	FBgn0034117	Length:	417	Species:	Drosophila melanogaster
Sequence 2:	NP_001120606.1	Gene:	gla / 100145767	XenbaseID:	XB-GENE-1008596	Length:	408	Species:	Xenopus tropicalis

Alignment Length:	410	Identity:	179/410 - (43%)
Similarity:	247/410 - (60%)	Gaps:	14/410 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YGTWGVFLGGILLLQVLQLSMGLDNGLALKPPMGWMSWERFRCITDCKLYPDECISEKLFQRHAD 66
            |....|.||.:|..|..|   .|.|||||.|||||:.||||.|.|:|:..|..||||:||...||
Frog     3 YAWLSVLLGTVLWPQGAQ---SLQNGLALTPPMGWLHWERFLCETNCERNPKNCISEQLFMDMAD 64

  Fly    67 LLVSEGYADAGYEYVIIDDCWLEKNRDNDTQKLVPDRKRFPNGLNALSDHIHNQGLKFGLYQDYG 131
            .:||||:.||||:|:.||||||...|| :..:|..|..|||.|:..|:|::|::||..|:|:|.|
Frog    65 KMVSEGWLDAGYQYLCIDDCWLAPERD-EKNRLQADPVRFPGGIKKLADYVHSRGLLLGIYEDVG 128

  Fly   132 TNTCAGYPGVIKHMKLDAQTFADWDVDYVKLDGC-YANISDMASGYPEFGRLLNETGRPMVYSCS 195
            :.||.|:||...:..:||||||:|.||.:|.||| |..:..:..||.:....||.|||.:|.||.
Frog   129 SKTCEGFPGSQGYYDIDAQTFAEWGVDLLKFDGCYYGTLDKLEDGYRQMSMALNRTGRKIVLSCE 193

  Fly   196 WPAYQEDAGEMPDYESLKQHCNLWRNWDDIEDSLESLMQIIDYFAKNQDRIQPHGGPGHWNDPDM 260
            ||.|:....:: :|..:.::||.|||:.||.||..|:..::|..:..|:.|.|..|||.||||||
Frog   194 WPLYERGIKKI-NYSEVAEYCNSWRNFGDITDSWGSVKAVMDLSSAVQEEIVPVAGPGSWNDPDM 257

  Fly   261 LLLGNYGLSYDQSKLQMAIWAIMAAPLIMSNDLAAVRPEIKAILQNRAVIAVDQDELGIQGRRVL 325
            |::||:|||::|...|||:|:||||||:|||||..:..|.||:||::.||:::||.||.||.||.
Frog   258 LVIGNFGLSWNQQVTQMALWSIMAAPLMMSNDLRDIPAESKALLQDKNVISINQDPLGAQGYRVF 322

  Fly   326 SRNQIEVWKRPITPVTKSGHHSYAVAFVSRRDDGAPYRIPFTVKEL--GLTNPKGYNVQDLYDAS 388
            ..:..|||:||:.      ..|.|||..:|.:.|.|.....::..|  .........:..|..:.
Frog   323 KADYFEVWERPLI------KGSLAVAVTNRNEIGGPRNFLLSLSLLWEDRVCQNSCFITQLLPSF 381

  Fly   389 SKLGVFQSESQFITRVNPNG 408
            .|.|.....|.....:||:|
Frog   382 QKYGHLNDTSLLSLWINPSG 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7997	NP_611119.1	AmyAc_family	31..408	CDD:298606	165/379 (44%)
gla	NP_001120606.1	AmyAc_family	29..312	CDD:393300	138/284 (49%)
gla	NP_001120606.1	Melibiase_2_C	315..401	CDD:375194	24/91 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90852
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62673
OrthoDB	1	1.010	-	-		D266390at33208
OrthoFinder	1	1.000	-	-		FOG0001285
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11452
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R31
SonicParanoid	1	1.000	-	-		X887
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.060