DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha44 and VMA5

DIOPT Version :9

Sequence 1:	NP_001137679.1	Gene:	Vha44 / 36826	FlyBaseID:	FBgn0262511	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_012843.1	Gene:	VMA5 / 853782	SGDID:	S000001563	Length:	392	Species:	Saccharomyces cerevisiae

Alignment Length:	378	Identity:	131/378 - (34%)
Similarity:	200/378 - (52%)	Gaps:	24/378 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 QASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFN-------LTPTHRSSPVSSCCGSS--- 523
            |..|.|.|...|:||   :.:...|:..|...|.. |.       :..:...|.|.:..|:|
Yeast    21 QPVTAPGSKTDSWFN---ETLIGGRAFVSDFKIPE-FKIGSLDTLIVESEELSKVDNQIGASIGK 81

  Fly   524 ----SQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGD 584
                .||.:...|:...  ..|::...:|:||..|||...|:.:.:|::::..:||.:..|:|.|
Yeast    82 IIEILQGLNETSTNAYR--TLPINNMPVPEYLENFQWQTRKFKLDKSIKDLITLISNESSQLDAD 144

  Fly   585 LKTKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTN 649
            ::.....||:.|.||...|:||||.|..|:|.|:||.|.|:|:||:|||:||.|||.:.:|:..:
Yeast   145 VRATYANYNSAKTNLAAAERKKTGDLSVRSLHDIVKPEDFVLNSEHLTTVLVAVPKSLKSDFEKS 209

  Fly   650 YEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEM 714
            ||.::..:||.|:.:|.|||:|.||||.||||..:||...|||:|||.|:|.|:||.:...|.|.
Yeast   210 YETLSKNVVPASASVIAEDAEYVLFNVHLFKKNVQEFTTAAREKKFIPREFNYSEELIDQLKKEH 274

  Fly   715 TKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKKSVKR 779
            ....:.::.....|||..|..:.:.|....|:|||||:||||||||||.:|...:|....|::.:
Yeast   275 DSAASLEQSLRVQLVRLAKTAYVDVFINWFHIKALRVYVESVLRYGLPPHFNIKIIAVPPKNLSK 339

  Fly   780 LRDVLNQLYGHLDG----ASAGGAVSSADNVDIPGLGFGQSEYFPYVFYKVNI 828
            .:..|...:|.|.|    ....|.::..|...........:||.|:|.|.:|:
Yeast   340 CKSELIDAFGFLGGNAFMKDKKGKINKQDTSLHQYASLVDTEYEPFVMYIINL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha44	NP_001137679.1	V-ATPase_C	6..>98	CDD:301617
		3-helical coiled coil	57..77	CDD:270211
		V-ATPase_C	<547..822	CDD:281248	109/278 (39%)
		3-helical coiled coil	570..596	CDD:270211	7/25 (28%)
		3-helical coiled coil	724..755	CDD:270211	12/30 (40%)
VMA5	NP_012843.1	COG5127	6..392	CDD:227456	130/376 (35%)
		3-helical coiled coil	66..86	CDD:270211	4/19 (21%)
		3-helical coiled coil	130..156	CDD:270211	7/25 (28%)
		3-helical coiled coil	284..315	CDD:270211	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346368
Domainoid	1	1.000	202	1.000	Domainoid score	I555
eggNOG	1	0.900	-	-		E1_COG5127
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1281
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S922
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		oto100167
orthoMCL	1	0.900	-	-		OOG6_101992
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
TreeFam	1	0.960	-	-
	14	13.680