Protein Alignment Vha44 and atp6v1c1

DIOPT Version :10

• Sequence 1: NP_725565.3
• Gene: Vha44 / 36826
• FlyBaseID: FBgn0287825
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_989172.1
• Gene: atp6v1c1 / 394779
• XenbaseID: XB-GENE-948409
• Length: 382
• Species: Xenopus tropicalis
• Alignment Length: 831
• Identity: 245/831 - (29%)
• Similarity: 311/831 - (37%)
• Gaps: 451/831 - (54%)

  Fly     2 MSEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYV 66
            |:|:|:|||||:||||||::.:...|:|.:||..|.||:||||||||||.||||||:|.|||.:|
 Frog     1 MTEFWLISAPGEKTCQQTWEKLMAATTKNNNLSTNAKFNIPDLKVGTLDVLVGLSDELAKLDAFV 65

  Fly    67 EQITRKVANYLGEVLEDQRDKLHENLMANNSPGPPDDSMPCRHHQRIKHLSLRHQRKHQHTHHQN 131
            |...:|||.|:.:||||.|||:.|||:||.
 Frog    66 EGTVKKVAQYMADVLEDSRDKVQENLLANG----------------------------------- 95

  Fly   132 KPQHYHHHHHHHQLPQDLKGKSAATCSPATPPAPASAPPHLPPACACDVLAPGSLTGGSLTNLST 196
                                                                             
 Frog    96 ----------------------------------------------------------------- 95

  Fly   197 SHEPEPEFDVCPCDECFACAPPSTSATASTLLADECYSQTASSMLSATRCALSTVAAIATGSGLG 261
                                                                             
 Frog    96 ----------------------------------------------------------------- 95

  Fly   262 NGPSTSAAAAAAASNSSGGGGGGGPASCSTLCSSAYFSTSAPTTSSSVHSSMSRSNSKRLNNNTC 326
                                                                             
 Frog    96 ----------------------------------------------------------------- 95

  Fly   327 SINNNKLSFRSGSHVSQLHLATQQPQHHHSHPHQQPHTNPLQSPVQKSMSEDEGDASNAHEDGET 391
                                                                             
 Frog    96 ----------------------------------------------------------------- 95

  Fly   392 DEDPKSPHSVQSDLSDAFDWWFNKPKRNSKKSSAQQQHETAQLQHQQTTQQHATPLTPQNHNQYQ 456
                                                                             
 Frog    96 ----------------------------------------------------------------- 95

  Fly   457 NQHLSKAMTFWHQASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFNLTPTHRSSPVSSCCG 521
                                                                             
 Frog    96 ----------------------------------------------------------------- 95

  Fly   522 SSSQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLK 586
                                   .:|..|:||||||||||||||||:||::||:|.:.|||.|||
 Frog    96 -----------------------VDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLK 137

  Fly   587 TKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYE 651
            .::.|||||||||||||:|..|||:||:||::|||:.|:||||||.||||:|||...|||:..||
 Frog   138 ARASAYNNLKGNLQNLERKNAGSLITRSLAEIVKKDDFVLDSEYLITLLVVVPKNNYNDWVKQYE 202

  Fly   652 KITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTK 716
            .:.:|:|||||.::.||.|..|.|||||:|..::|:..|||.||:||||.|||||:.|.|.||.:
 Frog   203 TLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFVVRDFQYNEEEMKADKEEMNR 267

  Fly   717 LMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKKSVKRLR 781
            |.||||||||||||||||||||||.|.||||||||||||||||||||||||:|::||||::|:||
 Frog   268 LSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTMKKLR 332

  Fly   782 DVLNQLYGHLDGASAGGAVSSADNVDIPGLGFGQSEYFPYVFYKVNIDMVE 832
            :||..||.|||.::|  ::..|. :|||||...|.||:|||:||::.:::|
 Frog   333 EVLYDLYKHLDSSAA--SIIDAP-MDIPGLNLSQQEYYPYVYYKIDCNLLE 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha44	NP_725565.3	V-ATPase_C	5..>98	CDD:472803	57/92 (62%)
		3-helical coiled coil	57..77	CDD:270211	10/19 (53%)
		V-ATPase_C	<547..822	CDD:460851	181/274 (66%)
		3-helical coiled coil	570..596	CDD:270211	14/25 (56%)
		3-helical coiled coil	724..755	CDD:270211	28/30 (93%)
atp6v1c1	NP_989172.1	V-ATPase_C	4..370	CDD:460851	238/816 (29%)
		3-helical coiled coil	56..76	CDD:270211	10/19 (53%)
		3-helical coiled coil	121..147	CDD:270211	14/25 (56%)
		3-helical coiled coil	275..306	CDD:270211	28/30 (93%)