Protein Alignment Vha44 and atp6v1c1a

DIOPT Version :10

• Sequence 1: NP_725565.3
• Gene: Vha44 / 36826
• FlyBaseID: FBgn0287825
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_958479.1
• Gene: atp6v1c1a / 368907
• ZFINID: ZDB-GENE-030616-612
• Length: 383
• Species: Danio rerio
• Alignment Length: 831
• Identity: 246/831 - (29%)
• Similarity: 310/831 - (37%)
• Gaps: 450/831 - (54%)

  Fly     2 MSEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYV 66
            |:|:|:|||||:||||||:|.:...|::.:||..|.||:||||||||||.||||||:|.|||.:|
Zfish     1 MTEFWLISAPGEKTCQQTWDKLMTATTRTNNLSTNNKFNIPDLKVGTLDVLVGLSDELAKLDAFV 65

  Fly    67 EQITRKVANYLGEVLEDQRDKLHENLMANNSPGPPDDSMPCRHHQRIKHLSLRHQRKHQHTHHQN 131
            |.:.:|||.|:.:||||.|||:.|||:||.
Zfish    66 ESVVKKVAQYMADVLEDSRDKVQENLLANG----------------------------------- 95

  Fly   132 KPQHYHHHHHHHQLPQDLKGKSAATCSPATPPAPASAPPHLPPACACDVLAPGSLTGGSLTNLST 196
                                                                             
Zfish    96 ----------------------------------------------------------------- 95

  Fly   197 SHEPEPEFDVCPCDECFACAPPSTSATASTLLADECYSQTASSMLSATRCALSTVAAIATGSGLG 261
                                                                             
Zfish    96 ----------------------------------------------------------------- 95

  Fly   262 NGPSTSAAAAAAASNSSGGGGGGGPASCSTLCSSAYFSTSAPTTSSSVHSSMSRSNSKRLNNNTC 326
                                                                             
Zfish    96 ----------------------------------------------------------------- 95

  Fly   327 SINNNKLSFRSGSHVSQLHLATQQPQHHHSHPHQQPHTNPLQSPVQKSMSEDEGDASNAHEDGET 391
                                                                             
Zfish    96 ----------------------------------------------------------------- 95

  Fly   392 DEDPKSPHSVQSDLSDAFDWWFNKPKRNSKKSSAQQQHETAQLQHQQTTQQHATPLTPQNHNQYQ 456
                                                                             
Zfish    96 ----------------------------------------------------------------- 95

  Fly   457 NQHLSKAMTFWHQASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFNLTPTHRSSPVSSCCG 521
                                                                             
Zfish    96 ----------------------------------------------------------------- 95

  Fly   522 SSSQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLK 586
                                   .:|..|:||||||||||||||||:||::|||||:.|||.|||
Zfish    96 -----------------------VDLVTYVTRFQWDMAKYPIKQSLKNISEIISKQVSQIDNDLK 137

  Fly   587 TKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYE 651
            .::.|||||||||||||:|..||||||:|||:|||:.|:||||||.||||:|||....||...||
Zfish   138 ARASAYNNLKGNLQNLERKNAGSLLTRSLADIVKKDDFVLDSEYLITLLVVVPKTNYTDWQRTYE 202

  Fly   652 KITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTK 716
            .:.:|:||||:.|:.||.|..||.||||:|..::|:..|||.||.||||.|||||:.|.|.|||:
Zfish   203 TLAEMVVPRSTNLLFEDHDSGLFTVTLFRKAIDDFRHKARENKFTVRDFQYNEEEMKADKEEMTR 267

  Fly   717 LMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKKSVKRLR 781
            |.||||||||||||||||||||||.|.:|:|||||||||||||||||||||:|::||||::|:||
Zfish   268 LSTDKKKQFGPLVRWLKVNFSEAFIAWVHIKALRVFVESVLRYGLPVNFQAMLLQPNKKNMKKLR 332

  Fly   782 DVLNQLYGHLDGASAGGAVSSADNVDIPGLGFGQSEYFPYVFYKVNIDMVE 832
            :||..||.|||.::|  |:.....:|||||...|.||:|||:||::.::::
Zfish   333 EVLYDLYKHLDSSAA--AIIDQSAMDIPGLNLSQQEYYPYVYYKIDCNLLD 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha44	NP_725565.3	V-ATPase_C	5..>98	CDD:472803	57/92 (62%)
		3-helical coiled coil	57..77	CDD:270211	10/19 (53%)
		V-ATPase_C	<547..822	CDD:460851	183/274 (67%)
		3-helical coiled coil	570..596	CDD:270211	16/25 (64%)
		3-helical coiled coil	724..755	CDD:270211	26/30 (87%)
atp6v1c1a	NP_958479.1	V-ATPase_C	4..371	CDD:460851	240/816 (29%)
		3-helical coiled coil	56..76	CDD:270211	10/19 (53%)
		3-helical coiled coil	121..147	CDD:270211	16/25 (64%)
		3-helical coiled coil	275..306	CDD:270211	26/30 (87%)