DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha44 and vma5

DIOPT Version :9

Sequence 1:	NP_001137679.1	Gene:	Vha44 / 36826	FlyBaseID:	FBgn0262511	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_593891.1	Gene:	vma5 / 2543469	PomBaseID:	SPAPB2B4.05	Length:	394	Species:	Schizosaccharomyces pombe

Alignment Length:	297	Identity:	92/297 - (30%)
Similarity:	173/297 - (58%)	Gaps:	24/297 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 SPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKT 607
            ||.|   |::.|.|:.:::.:.:::..|:|.|:.:|...:.|::|:..::.......||::||::
pombe   102 SPLE---YVSSFAWNSSRFHMNKTISEISDRITSEIISFENDIRTRQTSFQQASSAFQNMQKKQS 163

  Fly   608 GSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYC 672
            |:|..::||::|.:|..:..|:|||.:.:.||..:...:|.:||.:||:::|||::.:.:|:::.
pombe   164 GNLSQKSLANIVHEEDVVHGSDYLTNVFIAVPLNLEKQFLNSYETLTDLVIPRSAKKLDQDSEFV 228

  Fly   673 LFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFS 737
            |:.|.:|||.|:.|...|||.|:.:|:|.:.:......::|.......:|:....|:|:..:.||
pombe   229 LYTVVVFKKTADSFITKAREAKYTIREFTFEQGLRETEQSEFDDAAVKEKRMLSSLLRYASIAFS 293

  Fly   738 EAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKKSVKRLRDVLNQLYGHLD---------- 792
            |:|...||:|.|.|:|||:||||||.:|.:::.:|..||..:::::|...|.:|.
pombe   294 ESFQGWIHLKCLCVYVESILRYGLPPDFSSVIFQPMAKSEVKIKNILLSKYAYLAQNPVGNNKVK 358

  Fly   793 --GASAGGAVSSAD-NVDIPGLGFGQSEYFPYVFYKV 826
              .:|||...|.|| |:|        .||.|:|.:.|
pombe   359 NVDSSAGLDESMADLNLD--------EEYLPFVLFTV 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha44	NP_001137679.1	V-ATPase_C	6..>98	CDD:301617
		3-helical coiled coil	57..77	CDD:270211
		V-ATPase_C	<547..822	CDD:281248	87/287 (30%)
		3-helical coiled coil	570..596	CDD:270211	6/25 (24%)
		3-helical coiled coil	724..755	CDD:270211	12/30 (40%)
vma5	NP_593891.1	COG5127	1..394	CDD:227456	92/297 (31%)
		3-helical coiled coil	61..81	CDD:270211
		3-helical coiled coil	126..152	CDD:270211	6/25 (24%)
		3-helical coiled coil	280..311	CDD:270211	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I821
eggNOG	1	0.900	-	-		E1_COG5127
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1281
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		oto101921
orthoMCL	1	0.900	-	-		OOG6_101992
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
TreeFam	1	0.960	-	-
	12	11.800