DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZSCAN12

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001156863.1	Gene:	ZSCAN12 / 9753	HGNCID:	13172	Length:	611	Species:	Homo sapiens

Alignment Length:	589	Identity:	150/589 - (25%)
Similarity:	233/589 - (39%)	Gaps:	92/589 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LQETKVALMEDDPLTQETTSFPEIIK-----LATQEEEGVTEPQELGGR------NFFYPEIKIE 132
            ::|.|....:|..|.:..|...|:.:     ...||..|   |:|...|      .:..||...:
Human    21 IEEEKYTTRQDWDLRKNNTHSREVFRQYFRQFCYQETSG---PREALSRLRELCHQWLRPETHTK 82

  Fly   133 EHELDTLPRIEIL-----ERSANTQENQDQ--------LEGAARRLRKRLKAEDGS--SVDKDKD 182
            |..|:.|...:.|     |..|..||...:        ||...|.|     .|.|.  ||...:.
Human    83 EQILELLVLEQFLTILPEELQAWVQEQHPESGEEVVTVLEDLEREL-----DEPGEQVSVHTGEQ 142

  Fly   183 EDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPK-EDIQLDLKAEELDEFVDEETDPDFSCLVPS 246
            |..::||..    .::.|.|..|..::  ..:|| |..:|:.:.|::   :|.||..::..|...
Human   143 EMFLQETVR----LRKEGEPSMSLQSM--KAQPKYESPELESQQEQV---LDVETGNEYGNLKQE 198

  Fly   247 DNSSEDDGGSDGFDSDSDFELDNGK-------QEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRE 304
            .:...:..|.    :.|.||.|..|       :|    |:.....|....:..|  :|....:..
Human   199 VSEEMEPHGK----TSSKFENDMSKSARCGETRE----PEEITEEPSACSREDK--QPTCDENGV 253

  Fly   305 LLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQ 367
            .|.:.....|...:...:   ....|..|.......:.:..|.|: |..|..| .|  ||:.|..
Human   254 SLTENSDHTEHQRICPGE---ESYGCDDCGKAFSQHSHLIEHQRI-HTGDRPY-KCEECGKAFRG 313

  Fly   368 RKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDY 432
            |.||..|.::|.....:||:.|.|:|.....|..||::|..   :..:.|:.|.|.|..|..: :
Human   314 RTVLIRHKIIHTGEKPYKCNECGKAFGRWSALNQHQRLHTG---EKHYHCNDCGKAFSQKAGL-F 374

  Fly   433 HKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELM 497
            |.:..|.....::  |::|||.| :.|.:......:|.......|::|||.......|..|||:.
Human   375 HHIKIHTRDKPYQ--CTQCNKSF-SRRSILTQHQGVHTGAKPYECNECGKAFVYNSSLVSHQEIH 436

  Fly   498 HSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYH 560
            |.:|      ..||:.||... ..:||.||.: ||   .||  ::|.:|.|......:|..| ..
Human   437 HKEK------CYQCKECGKSF-SQSGLIQHQR-IH---TGEKPYKCDVCEKAFIQRTSLTEH-QR 489

  Fly   561 NHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--Y 623
            .|..||.:||..|.|||.:...|.||...||||..|.|..|...|....::.:| ||:|..:  |
Human   490 IHTGERPYKCDKCGKAFTQRSVLTEHQRIHTGERPYKCDECGNAFRGITSLIQH-QRIHTGEKPY 553

  Fly   624 EADK 627
            :.|:
Human   554 QCDE 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	0/1 (0%)
		FYDLN_acid	<191..268	CDD:302856	16/77 (21%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZSCAN12	NP_001156863.1	SCAN	42..152	CDD:128708	28/121 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..175		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..264		12/75 (16%)
		C2H2 Zn finger	248..268	CDD:275368	2/19 (11%)
		C2H2 Zn finger	276..296	CDD:275368	4/20 (20%)
		COG5048	299..579	CDD:227381	87/280 (31%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	6/20 (30%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..463	CDD:275368	7/20 (35%)
		C2H2 Zn finger	471..491	CDD:275368	5/20 (25%)
		C2H2 Zn finger	499..519	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/20 (30%)
		C2H2 Zn finger	555..575	CDD:275368	1/3 (33%)
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910