DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp423

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_011246862.1	Gene:	Zfp423 / 94187	MGIID:	1891217	Length:	1312	Species:	Mus musculus

Alignment Length:	655	Identity:	135/655 - (20%)
Similarity:	215/655 - (32%)	Gaps:	222/655 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LEGAARRLRKRLKA-EDGSSV----DKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKE 217
            |||.....||..:| ||.:||    ::::|::.||                  |.::......::
Mouse    56 LEGEPECDRKTSRALEDRNSVTSQEERNEDDEDVE------------------DESIYTCDHCQQ 102

  Fly   218 DIQLDLKAEELDEFVDE---------ETDPDFSCLVPSDNSSEDDGG-----SDGFDSDSDFELD 268
            |.      |.|.:..|.         :.||..| .|.|..||:|...     .||.|      |.
Mouse   103 DF------ESLADLTDHRAHRCPGDGDDDPQLS-WVASSPSSKDVASPTQMIGDGCD------LG 154

  Fly   269 NGKQEFAV-LPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAI 332
            .|::|... ||.......|.:          :|:|    ..::.:|...|.:..|       |..
Mouse   155 LGEEEGGTGLPYPCQFCDKSF----------IRLS----YLKRHEQIHSDKLPFK-------CTF 198

  Fly   333 CNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQN 395
            |:.|..:.....||.:| |..|..| .|  |...|::...|..|:..|.:...||||||::.|.:
Mouse   199 CSRLFKHKRSRDRHIKL-HTGDKKY-HCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSS 261

  Fly   396 SRHLESHQQVHM----------DPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSE-FKFTCS 449
            :..|:||.|.|.          ..|.|..|.||.|..||.....::.|.|..|...|| ....|.
Mouse   262 TSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCI 326

  Fly   450 ECNKKFLTERKLKNHMSSMH--------------------------------------------- 469
            .|.:.|:.|..|..|:...|
Mouse   327 HCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGS 391

  Fly   470 -------------------DPESTI---------------------ICDKCGKQMRTKI-ILKKH 493
                               .|:||:                     .|..|.|:..|.: :|:.|
Mouse   392 VASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQSWPKVVYSCPYCSKRDFTSLAVLEIH 456

  Fly   494 QELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESA---------GEHRCHICAKVSP 549
            .:.:|:|||:   :...||||...:..:..|.:|::.:|...|         ....|:.|.::..
Mouse   457 LKTIHADKPQ---QSHTCQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFA 518

  Fly   550 NARALRRHIYHNH--------ECERKFKCTMCEKAFKRPQELKEHTS------------------ 588
            :..:|:.||..:|        :....|.|..|...|.....|.||..
Mouse   519 DINSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTKLESPVVQP 583

  Fly   589 THTGEVLYTCPNCPMT--FFCSANMYKHRQRLHR----AQYEADKNQPKPPNILKISRNASTQNK 647
            |.:...:|:||.|..:  |.....:.||.:..|:    |..:..|.:..|     :|.:....:.
Mouse   584 TQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSP-----VSSDVEVSSP 643

  Fly   648 PKQEI 652
            .:|.:
Mouse   644 KRQRL 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	16/90 (18%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	25/86 (29%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	6/21 (29%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/37 (16%)
		C2H2 Zn finger	598..619	CDD:275368	6/22 (27%)
Zfp423	XP_011246862.1	C2H2 Zn finger	168..188	CDD:275368	4/33 (12%)
		C2H2 Zn finger	196..216	CDD:275368	6/20 (30%)
		COG5048	222..623	CDD:227381	82/404 (20%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		C2H2 Zn finger	293..312	CDD:275368	6/18 (33%)
		C2H2 Zn finger	439..460	CDD:275368	6/20 (30%)
		C2H2 Zn finger	471..495	CDD:275368	7/23 (30%)
		C2H2 Zn finger	510..529	CDD:275368	5/18 (28%)
		C2H2 Zn finger	692..712	CDD:275368
		C2H2 Zn finger	722..743	CDD:275368
		C2H2 Zn finger	750..771	CDD:275368
		C2H2 Zn finger	780..801	CDD:275368
		C2H2 Zn finger	811..831	CDD:275368
		C2H2 Zn finger	837..855	CDD:275368
		C2H2 Zn finger	916..937	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	989..1009	CDD:275368
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910