DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF101

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_149981.2	Gene:	ZNF101 / 94039	HGNCID:	12881	Length:	436	Species:	Homo sapiens

Alignment Length:	476	Identity:	107/476 - (22%)
Similarity:	170/476 - (35%)	Gaps:	123/476 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDS-------DFELDNGKQEF 274
            ||:.::...||            ::.|.||..:...|...:.|.:.:       |.:::|..|..
Human     7 EDVAVNFTQEE------------WALLSPSQKNLYRDVTLETFRNLASVGIQWKDQDIENLYQNL 59

  Fly   275 AVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDV--------IIAKFFTSVLP-- 329
            .:                     |:|...|.|..||:..|..:.        :..|..|.|.|
Human    60 GI---------------------KLRSLVERLCGRKEGNEHRETFSQIPDCHLNKKSQTGVKPCK 103

  Fly   330 CAICN--LLVHNFTE--MQRH--HRLTH---------------------------------QVDP 355
            |::|.  .|.|:|.:  |:.|  |:.:.                                 :..|
Human   104 CSVCGKVFLRHSFLDRHMRAHAGHKRSECGGEWRETPRKQKQHGKASISPSSGARRTVTPTRKRP 168

  Fly   356 GYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLC 420
            .....||:.|....:...|...|.....:||....::|..|.....|.::|..   :..:.|..|
Human   169 YECKVCGKAFNSPNLFQIHQRTHTGKRSYKCREIVRAFTVSSFFRKHGKMHTG---EKRYECKYC 230

  Fly   421 SKTFLSKTAIDYHKL-----NKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKC 480
            .|      .|||..|     ..|..:..:|  |.:|.|.|::...|:.|....|..|.:..|.:|
Human   231 GK------PIDYPSLFQIHVRTHTGEKPYK--CKQCGKAFISAGYLRTHEIRSHALEKSHQCQEC 287

  Fly   481 GKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHI 543
            ||::.....|.:| |..||.     .:|.:||.|....:..|.|:.|.::    ..||  :.|:.
Human   288 GKKLSCSSSLHRH-ERTHSG-----GKLYECQKCAKVFRCPTSLQAHERA----HTGERPYECNK 342

  Fly   544 CAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCS 608
            |.|........||| ...|..|:.::||.|.|||.....|:.|..|||||..:.|..|...|
Human   343 CGKTFNYPSCFRRH-KKTHSGEKPYECTRCGKAFGWCSSLRRHEMTHTGEKPFDCKQCGKVF--- 403

  Fly   609 ANMYKHRQRLHRAQYEADKNQ 629
              .:.:..|||...:.|.::|
Human   404 --TFSNYLRLHERTHLAGRSQ 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	10/57 (18%)
		C2H2 Zn finger	330..351	CDD:275368	8/26 (31%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	9/38 (24%)
		C2H2 Zn finger	386..406	CDD:275368	4/19 (21%)
		zf-C2H2_8	389..465	CDD:292531	18/80 (23%)
		C2H2 Zn finger	417..438	CDD:275368	7/25 (28%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
ZNF101	NP_149981.2	KRAB	4..>46	CDD:214630	9/50 (18%)
		KRAB	4..43	CDD:279668	9/47 (19%)
		C2H2 Zn finger	104..124	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..164		0/35 (0%)
		lambda-1	149..>209	CDD:212564	9/59 (15%)
		C2H2 Zn finger	171..191	CDD:275368	4/19 (21%)
		COG5048	<176..357	CDD:227381	50/202 (25%)
		C2H2 Zn finger	199..219	CDD:275368	4/19 (21%)
		C2H2 Zn finger	227..247	CDD:275368	7/25 (28%)
		zf-H2C2_2	240..264	CDD:290200	6/25 (24%)
		C2H2 Zn finger	255..276	CDD:275368	6/20 (30%)
		C2H2 Zn finger	284..304	CDD:275368	7/20 (35%)
		C2H2 Zn finger	312..332	CDD:275368	6/23 (26%)
		zf-H2C2_2	324..349	CDD:290200	7/28 (25%)
		COG5048	336..>407	CDD:227381	24/76 (32%)
		C2H2 Zn finger	340..360	CDD:275368	6/20 (30%)
		zf-H2C2_2	353..375	CDD:290200	9/22 (41%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		zf-H2C2_2	380..404	CDD:290200	10/28 (36%)
		C2H2 Zn finger	396..416	CDD:275368	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910