DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF160

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	297	Identity:	90/297 - (30%)
Similarity:	137/297 - (46%)	Gaps:	25/297 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKS 392
            |..|..|....:.:..|.|: |..:..| .|  ||:.|:.|..||.|..:|.....:||:.|.|.
Human   371 CNECGKLFTQNSHLISHWRI-HTGEKPY-KCNECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKV 433

  Fly   393 FQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLT 457
            |:.:.:|..|::||..   :..:.|:.|.|.|...:.:..|:: .|.....||  |:||:|.|..
Human   434 FRYNSYLGRHRRVHTG---EKPYKCNECGKAFSMHSNLATHQV-IHTGTKPFK--CNECSKVFTQ 492

  Fly   458 ERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMT 522
            ..:|.|| ..:|..|....|::|||....:..|..||.:...:||      .:|..||   |..|
Human   493 NSQLANH-RRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHSGEKP------YKCIECG---KSFT 547

  Fly   523 GLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKE 585
             .|.|::|.....:||  ::|:.|.||......|.|| :..|..|:.:||..|.:||.....|..
Human   548 -QKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQLARH-WRVHTGEKPYKCNDCGRAFSDRSSLTF 610

  Fly   586 HTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            |.:.||||..|.|..|...|..::.:..|| |:|..:
Human   611 HQAIHTGEKPYKCHECGKVFRHNSYLATHR-RIHTGE 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200	3/8 (38%)
		COG5048	367..810	CDD:227381	90/297 (30%)
		C2H2 Zn finger	371..391	CDD:275368	5/20 (25%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		zf-H2C2_2	411..436	CDD:290200	9/24 (38%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..463	CDD:290200	7/26 (27%)
		C2H2 Zn finger	455..475	CDD:275368	5/20 (25%)
		C2H2 Zn finger	483..503	CDD:275368	8/20 (40%)
		zf-H2C2_2	496..519	CDD:290200	9/23 (39%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		zf-H2C2_2	523..548	CDD:290200	10/34 (29%)
		C2H2 Zn finger	539..559	CDD:275368	8/23 (35%)
		zf-H2C2_2	551..576	CDD:290200	8/24 (33%)
		C2H2 Zn finger	567..587	CDD:275368	7/20 (35%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		zf-H2C2_2	607..632	CDD:290200	10/24 (42%)
		C2H2 Zn finger	623..643	CDD:275368	6/20 (30%)
		zf-H2C2_2	635..659	CDD:290200	4/13 (31%)
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..715	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		zf-H2C2_2	747..770	CDD:290200
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910