DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF551

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_612356.2	Gene:	ZNF551 / 90233	HGNCID:	25108	Length:	670	Species:	Homo sapiens

Alignment Length:	327	Identity:	92/327 - (28%)
Similarity:	146/327 - (44%)	Gaps:	29/327 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC-CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSF 393
            |..|.......:.:.||.|: |..:..|..| ||:.|.|...|..|..||.....::||.|.|||
Human   365 CGECGKSFRQSSSLFRHQRV-HSGERPYQCCECGKSFRQIFNLIRHRRVHTGEMPYQCSDCGKSF 428

  Fly   394 QNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTE 458
            .....|..||::|   :.:..:.|..|.|:|...:.:..|   :.:...:..:.||||.|.|..:
Human   429 SCKSELIQHQRIH---SGERPYECRECGKSFRQFSNLIRH---RSIHTGDRPYECSECEKSFSRK 487

  Fly   459 RKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTG 523
            ..|..| ..:|..|....|.:|||....|..|.:|:.:....:|      .:|..||...:..:|
Human   488 FILIQH-QRVHTGERPYECSECGKSFTRKSDLIQHRRIHTGTRP------YECSECGKSFRQRSG 545

  Fly   524 LKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEH 586
            |.|| :.:|   .||  :.|..|.|....:.:|.:| ...|..||.::|:.|.|:|.:...|.:|
Human   546 LIQH-RRLH---TGERPYECSECGKSFSQSASLIQH-QRVHTGERPYECSECGKSFSQSSSLIQH 605

  Fly   587 TSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YEAD---KNQPKPPNILKISRNASTQN 646
            ...||||..|.|..|...|...:::.:| ||:|..:  ||..   |:..:..|::: .|...|:.
Human   606 QRGHTGERPYECSQCGKPFTHKSDLIQH-QRVHTGERPYECSECGKSFSRKSNLIR-HRRVHTEE 668

  Fly   647 KP 648
            :|
Human   669 RP 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/18 (39%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF551	NP_612356.2	KRAB	29..>71	CDD:214630
		KRAB	29..68	CDD:279668
		C2H2 Zn finger	253..273	CDD:275368
		COG5048	279..624	CDD:227381	80/277 (29%)
		C2H2 Zn finger	281..301	CDD:275368
		C2H2 Zn finger	311..329	CDD:275368
		C2H2 Zn finger	337..357	CDD:275368
		zf-H2C2_2	349..374	CDD:290200	2/8 (25%)
		C2H2 Zn finger	365..385	CDD:275368	5/20 (25%)
		zf-H2C2_2	377..402	CDD:290200	9/25 (36%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		zf-H2C2_2	405..430	CDD:290200	10/24 (42%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		zf-H2C2_2	433..458	CDD:290200	8/27 (30%)
		C2H2 Zn finger	449..469	CDD:275368	5/22 (23%)
		zf-H2C2_2	461..486	CDD:290200	7/27 (26%)
		C2H2 Zn finger	477..497	CDD:275368	8/20 (40%)
		zf-H2C2_2	490..514	CDD:290200	8/24 (33%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		zf-H2C2_2	517..542	CDD:290200	6/30 (20%)
		C2H2 Zn finger	533..553	CDD:275368	7/20 (35%)
		zf-H2C2_2	546..570	CDD:290200	9/27 (33%)
		C2H2 Zn finger	561..581	CDD:275368	5/20 (25%)
		zf-H2C2_2	573..598	CDD:290200	9/25 (36%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		C2H2 Zn finger	617..637	CDD:275368	6/20 (30%)
		zf-H2C2_2	629..654	CDD:290200	7/25 (28%)
		C2H2 Zn finger	645..665	CDD:275368	3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910