DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF382

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_116214.2	Gene:	ZNF382 / 84911	HGNCID:	17409	Length:	550	Species:	Homo sapiens

Alignment Length:	321	Identity:	86/321 - (26%)
Similarity:	128/321 - (39%)	Gaps:	40/321 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 LLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRK 369
            |:|::.....:|...:.:....::|                 .|...:..|.:...||..|.::.
Human   262 LMEKKPSAYNKYGKFLCRKPVFIMP-----------------QRPQTEEKPFHCPYCGNNFRRKS 309

  Fly   370 VLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSK-TAIDYH 433
            .|.||..:|.....:.|:.|.|:|:....|..|::.|::..   .|.|..|.|:|..| |...:|
Human   310 YLIEHQRIHTGEKPYVCNQCGKAFRQKTALTLHEKTHIEGK---PFICIDCGKSFRQKATLTRHH 371

  Fly   434 KLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMH 498
            |.:    ..|..:.|.:|...|..:..|.:|..: |..|....|::|||....|..|..||....
Human   372 KTH----TGEKAYECPQCGSAFRKKSYLIDHQRT-HTGEKPYQCNECGKAFIQKTTLTVHQRTHT 431

  Fly   499 SDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHN 561
            .:||      ..|..||......|.|..|.: ||   .||  :.|:.|.|.......|..| :..
Human   432 GEKP------YICNECGKSFCQKTTLTLHQR-IH---TGEKPYICNECGKSFRQKAILTVH-HRI 485

  Fly   562 HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            |..|:...|..|.|||.|...|..|..|||||..|.|..|...|.|.:|:..| |:.|:.:
Human   486 HTGEKSNGCPQCGKAFSRKSNLIRHQKTHTGEKPYECKQCGKFFSCKSNLIVH-QKTHKVE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	1/20 (5%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	20/76 (26%)
		C2H2 Zn finger	417..438	CDD:275368	8/21 (38%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF382	NP_116214.2	Mediates interaction with TRIM28. /evidence=ECO:0000250	1..105
		Represses transcription. /evidence=ECO:0000250	5..46
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		Represses transcription. /evidence=ECO:0000250	70..211
		C2H2 Zn finger	214..234	CDD:275368
		Required for transcriptional repression activity, probably mediates sequence-specific DNA-binding. /evidence=ECO:0000250	296..550		80/270 (30%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		zf-H2C2_2	310..335	CDD:290200	8/24 (33%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		COG5048	<354..533	CDD:227381	61/194 (31%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		zf-H2C2_2	367..389	CDD:290200	5/25 (20%)
		C2H2 Zn finger	382..402	CDD:275368	5/20 (25%)
		zf-H2C2_2	394..419	CDD:290200	8/25 (32%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		zf-H2C2_2	423..445	CDD:290200	8/27 (30%)
		C2H2 Zn finger	438..458	CDD:275368	6/20 (30%)
		zf-H2C2_2	451..475	CDD:290200	9/27 (33%)
		C2H2 Zn finger	466..486	CDD:275368	5/20 (25%)
		C2H2 Zn finger	494..514	CDD:275368	8/19 (42%)
		zf-C2H2	494..514	CDD:278523	8/19 (42%)
		zf-H2C2_2	506..531	CDD:290200	11/24 (46%)
		C2H2 Zn finger	522..542	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910