DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF541

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_011525670.1	Gene:	ZNF541 / 84215	HGNCID:	25294	Length:	1351	Species:	Homo sapiens

Alignment Length:	830	Identity:	147/830 - (17%)
Similarity:	252/830 - (30%)	Gaps:	314/830 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EDDPLTQETTSFPEIIKLATQE-------EEGVTEPQELGG---------RNFFYPEIKIEE--- 133
            ||||..      |:.:|:....       |.|:.|.|:.||         |..|   :|.:|
Human   500 EDDPCA------PKKVKVDCDSFLCQNPGEPGLQEAQKAGGLPADASPLFRQLF---LKSQEPLV 555

  Fly   134 -HELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGS--------------------SV 177
             ||     ::::.:....:|......:.||  :..:|.|.:|.                    :|
Human   556 SHE-----QMQVFQMITKSQRIFSHAQVAA--VSSQLPAPEGKPAALRPLQGPWPQQPPPLAPAV 613

  Fly   178 DKDKDEDGVEETAEPAPPKKRR---GRPRKSDAAVAPPQKPKEDIQLDLKAEELD-----EFVDE 234
            |......|..| ||.:|.::|:   |.||:     |.|...:.|.:..||...:.     ..:|.
Human   614 DSLHAGPGNPE-AEGSPARRRKTTPGVPRE-----ASPGSTRRDAKGGLKVAAVPTPLAAPSLDP 672

  Fly   235 ETDPDFSCLVPSDNSSEDDGGS----DGFDSDSDFELDNGKQE--FAVLPKR----------TVV 283
            ..:||.|.|.....||:   |:    |.|.|....:...|.:|  .|.||.:          .:.
Human   673 SRNPDISSLAKQLRSSK---GTLDLEDIFPSTGQRQTQLGGEEPPGASLPGKQAPAENGAASRIT 734

  Fly   284 RPKK---------YKKRTKPAEPKVRMSRELLEQRKKQQEEYD---------VIIAKFFTSVLPC 330
            :.:|         |:....|..|:....|       |::.:.|         |.:|.|.::..|.
Human   735 KGEKGPACSRGGGYRLLGNPRAPRFSGFR-------KEKAKMDMCCAASPSQVAMASFSSAGPPA 792

  Fly   331 AICNLLVHNFTEMQ--RHHRLTHQVDP---------------------GYMMC--CGRKFTQRKV 370
            ......:..|:.:|  ..:||.|.|..                     ...:|  |.:.|...|.
Human   793 DPSKSKLTIFSRIQGGNIYRLPHPVKEENVAGRGNQQNGSPTDWTKPRSTFVCKNCSQMFYTEKG 857

  Fly   371 LAEHVLVH---W-------NPDHFKCSVCEKSFQ-----NSRHLESHQQVHMDPAV--------- 411
            |:.|:..|   |       .|..|....|:...|     ..||.....:..:||..
Human   858 LSSHMCFHSDQWPSPRGKQEPQVFGTEFCKPLRQVLRPEGDRHSPPGTKKPLDPTAAAPLVVPQS 922

  Fly   412 -----------KLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSE-----CNKK------ 454
                       .:....:...:...||.:....|..|..|.|    |..|     |::.
Human   923 IPVVPVTRHIGSMAMGQEKDGEERDSKESSQQRKRKKRPPPS----TAGEPGPAGCHQSRLRSPM 983

  Fly   455 FLTERKLKN----------------------------HMSSMHDPESTI--ICDK-------CGK 482
            ||.:..||.                            ..|:...|:..|  :.|:       |..
Human   984 FLVDCLLKGLFQCSPYTPPPMLSPIREGSGVYFNTLCSTSTQASPDQLISSMLDQVDGSFGICVV 1048

  Fly   483 QMRTKIILKKHQELMHSDKPRPE-PELQQCQICGAWLKGMTGLKQHMKSI--------HVESAGE 538
            :..|||.::.|..:  ..:.:.| ||||:        :.:.|..:|:.|:        .:.|..:
Human  1049 KDDTKISIEPHINI--GSRFQAEIPELQE--------RSLAGTDEHVASLVWKPWGDMMISSETQ 1103

  Fly   539 HR----CHI-CAKVSPNARA-LRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTST---HTGEV 594
            .|    |:: |:.|.|.... |...::..||.:...:..:.....:.|.:.:.|...   :||..
Human  1104 DRVTELCNVACSSVMPGGGTNLELALHCLHEAQGNVQVALETLLLRGPHKPRTHLLADYRYTGSD 1168

  Fly   595 LY-----------------------------TCPNCPMTFFCSANMYKH--------RQRLHRAQ 622
            ::                             |...|...::....|.|.        .:|:.|..
Human  1169 VWTPIEKRLFKKAFYAHKKDFYLIHKMIQTKTVAQCVEYYYIWKKMIKFDCGRAPGLEKRVKREP 1233

  Fly   623 YEADKNQPKPP-----------------------NILKISRNASTQNKPK 649
            .|.::.:.|.|                       :||..|.||.::..|:
Human  1234 EEVERTEEKVPCSPRERPSHHPTPKLKTKSYRRESILSSSPNAGSKRTPE 1283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	22/88 (25%)
		C2H2 Zn finger	330..351	CDD:275368	4/22 (18%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	13/53 (25%)
		C2H2 Zn finger	386..406	CDD:275368	4/24 (17%)
		zf-C2H2_8	389..465	CDD:292531	19/139 (14%)
		C2H2 Zn finger	417..438	CDD:275368	3/20 (15%)
		C2H2 Zn finger	448..465	CDD:275368	6/55 (11%)
		C2H2 Zn finger	477..498	CDD:275368	6/27 (22%)
		C2H2 Zn finger	511..532	CDD:275368	3/28 (11%)
		C2H2 Zn finger	541..562	CDD:275368	5/22 (23%)
		C2H2 Zn finger	570..590	CDD:275368	2/22 (9%)
		C2H2 Zn finger	598..619	CDD:275368	4/28 (14%)
ZNF541	XP_011525670.1	C2H2 Zn finger	142..162	CDD:275368
		zf-C2H2	142..162	CDD:278523
		COG5048	150..>324	CDD:227381
		zf-H2C2_2	154..179	CDD:290200
		C2H2 Zn finger	170..195	CDD:275368
		C2H2 Zn finger	203..225	CDD:275368
		ELM2	1060..1115	CDD:279754	11/64 (17%)
		SANT	1170..1214	CDD:197842	2/43 (5%)
		SANT	1170..1213	CDD:304392	2/42 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910