DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF93

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_112495.2	Gene:	ZNF93 / 81931	HGNCID:	13169	Length:	620	Species:	Homo sapiens

Alignment Length:	404	Identity:	105/404 - (25%)
Similarity:	162/404 - (40%)	Gaps:	70/404 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 DSDFELDNGKQEF---AVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKF 323
            :..::.|...:.|   :.|.|..::...|...:.:........|..|.:.:            |.
Human   226 EKPYKCDKCDKAFIASSTLSKHEIIHTGKKPYKCEECGKAFNQSSTLTKHK------------KI 278

  Fly   324 FTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHF 384
            .|...|  |..|....:..:.:.:|.:: |..:..| :|  ||:.|...::|..|..:|.....:
Human   279 HTGEKPYKCEECGKAFNQSSTLTKHKKI-HTGEKPY-VCEECGKAFKYSRILTTHKRIHTGEKPY 341

  Fly   385 KCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCS 449
            ||:.|.|:|..|..|..|:.:||.   |..:.|:.|.|.|:..:.:..|   |.|...|..:.|.
Human   342 KCNKCGKAFIASSTLSRHEFIHMG---KKHYKCEECGKAFIWSSVLTRH---KRVHTGEKPYKCE 400

  Fly   450 ECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQIC 514
            ||.|.|.....|.:|..| |..|....|::|||.......|.|| |::|:.| :|    .:|:.|
Human   401 ECGKAFKYSSTLSSHKRS-HTGEKPYKCEECGKAFVASSTLSKH-EIIHTGK-KP----YKCEEC 458

  Fly   515 GAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRH-------------------- 557
            |......:.|.:| |.||   .||  ::|..|.|....:.:|.:|
Human   459 GKAFNQSSSLTKH-KKIH---TGEKPYKCEECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFN 519

  Fly   558 -----IYHN--HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHR 615
                 |.|.  |..|:.:||..|.|||.....|..|...||||..|.|..|...|..||.:..|:
Human   520 QSSTLIKHKKIHTREKPYKCEECGKAFHLSTHLTTHKILHTGEKPYRCRECGKAFNHSATLSSHK 584

  Fly   616 QRLHRAQ--YEADK 627
             ::|..:  ||.||
Human   585 -KIHSGEKPYECDK 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	0/5 (0%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/47 (15%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		COG5048	170..612	CDD:227381	105/404 (26%)
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		zf-H2C2_2	215..238	CDD:290200	1/11 (9%)
		C2H2 Zn finger	231..251	CDD:275368	4/19 (21%)
		zf-H2C2_2	244..268	CDD:290200	3/23 (13%)
		C2H2 Zn finger	259..279	CDD:275368	3/31 (10%)
		zf-H2C2_2	272..296	CDD:290200	6/35 (17%)
		C2H2 Zn finger	287..307	CDD:275368	3/20 (15%)
		zf-H2C2_2	300..324	CDD:290200	7/25 (28%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..350	CDD:290200	7/21 (33%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	6/22 (27%)
		zf-H2C2_2	384..408	CDD:290200	9/26 (35%)
		C2H2 Zn finger	399..419	CDD:275368	8/20 (40%)
		zf-H2C2_2	412..435	CDD:290200	9/23 (39%)
		C2H2 Zn finger	427..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	440..464	CDD:290200	10/29 (34%)
		C2H2 Zn finger	455..475	CDD:275368	6/20 (30%)
		zf-H2C2_2	467..492	CDD:290200	10/28 (36%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		zf-H2C2_2	495..520	CDD:290200	2/24 (8%)
		C2H2 Zn finger	511..531	CDD:275368	2/19 (11%)
		zf-H2C2_2	524..547	CDD:290200	9/22 (41%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		zf-H2C2_2	551..576	CDD:290200	10/24 (42%)
		C2H2 Zn finger	567..587	CDD:275368	6/20 (30%)
		zf-H2C2_2	580..602	CDD:290200	6/19 (32%)
		C2H2 Zn finger	595..615	CDD:275368	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910