DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF430

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_079465.3	Gene:	ZNF430 / 80264	HGNCID:	20808	Length:	570	Species:	Homo sapiens

Alignment Length:	416	Identity:	108/416 - (25%)
Similarity:	168/416 - (40%)	Gaps:	69/416 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EDIQLDLKAEELDE--FVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLP- 278
            ||:||....:.:||  ...|..|....||..:.:..              |:.|.....|....
Human   141 EDLQLRTGCKSVDECNLHKECYDELNQCLTTTQSEI--------------FQYDKYVNVFYKFSN 191

  Fly   279 ------KRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKK---QQEEYDVIIAKFFTSVLPCAICN 334
                  :.|..:|.|.||..|.....:.     |.|.|:   ::..|.            |..|.
Human   192 PNIQKIRHTGKKPFKCKKCDKSFCMLLH-----LTQHKRIHIRENSYQ------------CEECG 239

  Fly   335 LLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSR 397
            .:.:.|:.:.||.|: |..:..| .|  ||:.|.|...|..|.::|.....::|..|.|:|..|.
Human   240 KVFNWFSTLTRHRRI-HTGEKPY-KCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSS 302

  Fly   398 HLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLK 462
            ||.:|:::|..   :..:.|:.|.:.|...:.:..||:   :...|..:.|.||.|.|.....|.
Human   303 HLTTHKRIHTG---EKPYRCEECGRAFNRSSHLTTHKI---IHTGEKPYKCEECGKAFNQSSTLT 361

  Fly   463 NHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQH 527
            .| ..:|..|....|::|||.......|.|| :::|:.:     :..:|:.||......:.|.:|
Human   362 TH-KIIHAGEKPYKCEECGKAFYRFSYLTKH-KIIHTGE-----KFYKCEECGKGFNWSSTLTKH 419

  Fly   528 MKSIHVESAGE--HRCHICAKVSPNARALRRH-IYHNHECERKFKCTMCEKAFKRPQELKEHTST 589
             |.||   .||  ::|..|.|....:..|..| |.|..  |:.:||..|.|||.|..:|..|...
Human   420 -KRIH---TGEKPYKCEQCGKAFNESSNLTAHKIIHTG--EKPYKCEECGKAFNRSPKLTAHKVI 478

  Fly   590 HTGEVLYTCPNCPMTFFCSANMYKHR 615
            |:||..|.|..|...|...:|:.||:
Human   479 HSGEKPYKCEECGKAFNQFSNLTKHK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	11/52 (21%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/21 (33%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/18 (33%)
ZNF430	NP_079465.3	KRAB	35..96	CDD:214630
		KRAB	35..74	CDD:279668
		COG5048	202..562	CDD:227381	94/341 (28%)
		C2H2 Zn finger	207..227	CDD:275368	6/24 (25%)
		C2H2 Zn finger	235..255	CDD:275368	6/20 (30%)
		zf-H2C2_2	248..272	CDD:290200	9/25 (36%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		zf-H2C2_2	276..300	CDD:290200	7/23 (30%)
		C2H2 Zn finger	291..311	CDD:275368	8/19 (42%)
		zf-H2C2_2	303..328	CDD:290200	7/27 (26%)
		C2H2 Zn finger	319..339	CDD:275368	5/22 (23%)
		zf-H2C2_2	331..356	CDD:290200	8/27 (30%)
		C2H2 Zn finger	347..367	CDD:275368	7/20 (35%)
		C2H2 Zn finger	375..395	CDD:275368	7/20 (35%)
		C2H2 Zn finger	403..423	CDD:275368	6/20 (30%)
		zf-H2C2_2	416..439	CDD:290200	10/26 (38%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		zf-H2C2_2	443..468	CDD:290200	11/26 (42%)
		C2H2 Zn finger	459..479	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..496	CDD:290200	9/23 (39%)
		C2H2 Zn finger	487..507	CDD:275368	6/18 (33%)
		C2H2 Zn finger	515..535	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910