DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF614

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_079316.2	Gene:	ZNF614 / 80110	HGNCID:	24722	Length:	585	Species:	Homo sapiens

Alignment Length:	576	Identity:	143/576 - (24%)
Similarity:	223/576 - (38%)	Gaps:	118/576 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 TSFPEIIKLATQEEEGVTEPQELGGRNFFYPEI-KIEEHELDTLPRIEILE--RSANTQ------ 152
            ||.|:::......:|..|...::..:|  .|.| |::.|..:..|...:|:  :..|.|
Human    51 TSKPDVLSKLAHGQEPWTTDAKIQNKN--CPGIGKVDSHLQEHSPNQRLLKSVQQCNGQNTLRNI 113

  Fly   153 -----------ENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGV---------EETAEPAPPKK 197
                       :|.|..:    ..||.||:  ..|:...|...|:         |:|......::
Human   114 VHLSKTHFPIVQNHDTFD----LYRKNLKS--SLSLINQKRRHGINNPVEFIGGEKTLLHGKHER 172

  Fly   198 RRGRPRKSDAA--------VAPPQKPKEDIQLDLKAEELDEFVD-EETDPDFSCLVPSDN-SSED 252
            ...:.|.|:.|        |...|:.:       |.|:....:: |:|....|.|:..:| ..::
Human   173 THTKTRFSENAKCIHTKFQVFKHQRTQ-------KIEKPHACIECEQTFLRKSQLIYHENICIQE 230

  Fly   253 DGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYD 317
            :.||...:..|...|.....:.....|  :..|.:|:|.:     .|:.|....:|...:::.|
Human   231 NPGSGQCEKLSRSVLFTKHLKTNTTDK--ICIPNEYRKGS-----TVKSSLITHQQTHTEEKSY- 287

  Fly   318 VIIAKFFTSVLPCAICNLLVHNFTEMQRH---HRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLV 377
                       .|:.|.   ..|| |:|:   |:.||..:..| :|  ||:.||.:..|..|...
Human   288 -----------MCSECG---KGFT-MKRYLIAHQRTHSGEKPY-VCKECGKGFTVKSNLIVHQRT 336

  Fly   378 HWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKS 442
            |.....:.||.|.|.|...|:|..||:.|..   :..:.|..|.|.|..|:.:..|:.:....||
Human   337 HTGEKPYICSECGKGFTMKRYLVVHQRTHTG---EKPYMCSECGKGFTVKSNLIVHQRSHTGEKS 398

  Fly   443 EFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPE 507
               :.||||.|.|..:|.|..|..: |..|.:.||::|||...||..|..||.....:||
Human   399 ---YICSECGKGFTVKRTLVIHQRT-HTGEKSYICNECGKGFTTKRTLIIHQRTHTGEKP----- 454

  Fly   508 LQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHI---------CAKVSPNARALRRHIYHNHE 563
             .:|..||........|.||           .|||.         |.|...:...|..| ...|.
Human   455 -YECNECGKAFSQKICLIQH-----------ERCHTGKTPFVCTECGKSYSHKYGLITH-QRIHT 506

  Fly   564 CERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            .|:.::|..|.|||.....|..|..|||||..|.|.:|...|...:|:.||: ::|
Human   507 GEKPYECNECGKAFTTKSVLNVHQRTHTGERPYGCSDCEKAFSHLSNLVKHK-KMH 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	15/86 (17%)
		C2H2 Zn finger	330..351	CDD:275368	7/23 (30%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	8/16 (50%)
		C2H2 Zn finger	477..498	CDD:275368	9/20 (45%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/29 (21%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF614	NP_079316.2	KRAB	8..68	CDD:214630	4/16 (25%)
		KRAB	8..47	CDD:279668
		COG5048	<92..350	CDD:227381	60/294 (20%)
		C2H2 Zn finger	180..199	CDD:275368	4/18 (22%)
		C2H2 Zn finger	207..226	CDD:275368	4/18 (22%)
		C2H2 Zn finger	236..253	CDD:275368	2/16 (13%)
		C2H2 Zn finger	289..309	CDD:275368	7/23 (30%)
		zf-H2C2_2	301..325	CDD:290200	7/24 (29%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		zf-H2C2_2	329..353	CDD:290200	7/23 (30%)
		C2H2 Zn finger	345..365	CDD:275368	9/19 (47%)
		zf-H2C2_2	357..381	CDD:290200	7/26 (27%)
		C2H2 Zn finger	373..393	CDD:275368	6/19 (32%)
		COG5048	<383..562	CDD:227381	62/202 (31%)
		C2H2 Zn finger	401..421	CDD:275368	9/20 (45%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		zf-H2C2_2	442..466	CDD:290200	8/29 (28%)
		C2H2 Zn finger	457..477	CDD:275368	7/30 (23%)
		C2H2 Zn finger	485..505	CDD:275368	4/20 (20%)
		zf-H2C2_2	498..522	CDD:290200	9/24 (38%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		C2H2 Zn finger	541..561	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910