DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF557

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001037852.1	Gene:	ZNF557 / 79230	HGNCID:	28632	Length:	430	Species:	Homo sapiens

Alignment Length:	549	Identity:	124/549 - (22%)
Similarity:	207/549 - (37%)	Gaps:	144/549 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSA--NTQE 153
            |....::.||      ..:.||.||..||           :.|.....|..:...|..|  .|||
Human     8 PTAALSSLFP------ASQREGHTEGGEL-----------VNELLKSWLKGLVTFEDVAVEFTQE 55

  Fly   154 NQDQLEGAARRLRKRLKAED-------GSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAP 211
            ....|:.|.|.|.:.:..|:       |:.|||                      ||
Human    56 EWALLDPAQRTLYRDVMLENCRNLASLGNQVDK----------------------PR-------- 90

  Fly   212 PQKPKEDIQLDLKAEELDEFVDEE------TDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNG 270
                     |..:.|:.|:.:.||      |.||
Human    91 ---------LISQLEQEDKVMTEERGILSGTCPD------------------------------- 115

  Fly   271 KQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNL 335
                       |..|.|.|..|    ||:.:.|:  ||.:..:.|.:.:.|    ::..|..|..
Human   116 -----------VENPFKAKGLT----PKLHVFRK--EQSRNMKMERNHLGA----TLNECNQCFK 159

  Fly   336 LVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLE 400
            :....:.:.||.::.....|.....||:.::.|..||.|..:|.....::|:.|.|:|.:..:|.
Human   160 VFSTKSSLTRHRKIHTGERPYGCSECGKSYSSRSYLAVHKRIHNGEKPYECNDCGKTFSSRSYLT 224

  Fly   401 SHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHM 465
            .|:::|..   :..:.|..|.|||.:.:.:..| |..|..:..:|  |::|.::|.|:.....|
Human   225 VHKRIHNG---EKPYECSDCGKTFSNSSYLRPH-LRIHTGEKPYK--CNQCFREFRTQSIFTRH- 282

  Fly   466 SSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKS 530
            ..:|..|...:|::|||...|:..|..|..:...:.|      .:|..||...:..:.|.||:::
Human   283 KRVHTGEGHYVCNQCGKAFGTRSSLSSHYSIHTGEYP------YECHDCGRTFRRRSNLTQHIRT 341

  Fly   531 IHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGE 593
                ..||  :.|:.|.|...|:.:|..| ...|..|:.::|:.|.|:|.....:|:|..||||:
Human   342 ----HTGEKPYTCNECGKSFTNSFSLTIH-RRIHNGEKSYECSDCGKSFNVLSSVKKHMRTHTGK 401

  Fly   594 VLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            ..|.|..|..:|..::.:..| .|:|..|
Human   402 KPYECNYCGKSFTSNSYLSVH-TRMHNRQ 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	10/82 (12%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
ZNF557	NP_001037852.1	KRAB	43..100	CDD:214630	18/95 (19%)
		KRAB	43..82	CDD:279668	10/38 (26%)
		COG5048	<137..422	CDD:227381	75/306 (25%)
		C2H2 Zn finger	154..174	CDD:275368	4/19 (21%)
		C2H2 Zn finger	182..202	CDD:275368	6/19 (32%)
		zf-H2C2_2	194..219	CDD:290200	8/24 (33%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		zf-H2C2_2	222..247	CDD:290200	8/27 (30%)
		C2H2 Zn finger	238..258	CDD:275368	7/20 (35%)
		zf-H2C2_2	254..275	CDD:290200	7/23 (30%)
		C2H2 Zn finger	266..286	CDD:275368	5/20 (25%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-C2H2	320..342	CDD:278523	6/25 (24%)
		C2H2 Zn finger	322..342	CDD:275368	6/23 (26%)
		zf-H2C2_2	334..359	CDD:290200	8/28 (29%)
		C2H2 Zn finger	350..370	CDD:275368	6/20 (30%)
		zf-H2C2_2	362..386	CDD:290200	7/24 (29%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910