DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF426

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_077011.1	Gene:	ZNF426 / 79088	HGNCID:	20725	Length:	554	Species:	Homo sapiens

Alignment Length:	608	Identity:	130/608 - (21%)
Similarity:	215/608 - (35%)	Gaps:	144/608 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LHEFVSAAQSSLQETKVALMEDDPLT---QETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEI 129
            |||         ::|....:..|.||   |::.:|.::....||||..:.:..:    ...|.::
Human    19 LHE---------EKTPAGRIVADCLTDCYQDSVTFDDVAVDFTQEEWTLLDSTQ----RSLYSDV 70

  Fly   130 KIEEHE-LDTL-------PRIEILERSANTQENQDQLEGAARRLRKR--------LKAEDGSSVD 178
            .:|.:: |.|:       ..|..||:..:.......|:|...||..:        |:.:....:.
Human    71 MLENYKNLATVGGQIIKPSLISWLEQEESRTVQGGVLQGWEMRLETQWSILQQDFLRGQTSIGIQ 135

  Fly   179 KDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCL 243
            .:...:|.|.                                  ...|:..|...|.     |||
Human   136 LEGKHNGREL----------------------------------CDCEQCGEVFSEH-----SCL 161

  Fly   244 VPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQ 308
            .....:.     |.|...|.:   ..|| :|..|.::|....|  ......:|....::..::.|
Human   162 KTHVRTQ-----STGNTHDCN---QYGK-DFLTLCEKTSTGEK--LSEFNQSEKIFSLTPNIVYQ 215

  Fly   309 RKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVD---------PGYM------ 358
            |...||       |.|    .|:.|.....|.:.:|.|.| ||..:         ||::
Human   216 RTSTQE-------KSF----ECSHCGKSFINESYLQAHMR-THNGEKLYEWRNYGPGFIDSTSLS 268

  Fly   359 ------------MC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDP 409
                        .|  ||:.:.....|:.|:..|.....::|..|.|:|..|...:.|.:.|..
Human   269 VLIETLNAKKPYKCKECGKGYRYPAYLSIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHTG- 332

  Fly   410 AVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPEST 474
              :..:.|..|.|.|...:.:..| :..|  ..:..:.|.||.|.|||..:|..|:.: |..|..
Human   333 --EKPYVCKECGKAFTQYSGLSMH-VRSH--SGDKPYECKECGKSFLTSSRLIQHIRT-HTGEKP 391

  Fly   475 IICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEH 539
            .:|.:|||.......|..|.      :...|.:..:|:|||......:.|..||::...:.  .:
Human   392 FVCVECGKAFAVSSNLSGHL------RTHTEEKACECKICGKVFGYPSCLNNHMRTHSAQK--PY 448

  Fly   540 RCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMT 604
            .|..|.|....:..|:.|: ..|..|:.::|..|.|||......:.|..|||||..|.|..|...
Human   449 TCKECGKAFNYSTHLKIHM-RIHTGEKPYECKQCGKAFSHSSSFQIHERTHTGEKPYECKECGKA 512

  Fly   605 FFCSANMYKHRQRLHRAQYEADK 627
            |.||::.     |:|...:..:|
Human   513 FTCSSSF-----RIHEKTHTEEK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	3/12 (25%)
		FYDLN_acid	<191..268	CDD:302856	9/76 (12%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	8/16 (50%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF426	NP_077011.1	KRAB	42..98	CDD:214630	12/59 (20%)
		C2H2 Zn finger	148..168	CDD:275368	6/24 (25%)
		C2H2 Zn finger	176..214	CDD:275368	7/43 (16%)
		zf-C2H2	224..246	CDD:306579	7/26 (27%)
		C2H2 Zn finger	226..246	CDD:275368	6/20 (30%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		zf-H2C2_2	294..319	CDD:316026	7/24 (29%)
		C2H2 Zn finger	310..330	CDD:275368	6/19 (32%)
		COG5048	<334..486	CDD:227381	42/164 (26%)
		C2H2 Zn finger	338..358	CDD:275368	5/20 (25%)
		C2H2 Zn finger	366..386	CDD:275368	9/20 (45%)
		C2H2 Zn finger	394..414	CDD:275368	6/25 (24%)
		C2H2 Zn finger	422..442	CDD:275368	7/19 (37%)
		C2H2 Zn finger	450..470	CDD:275368	5/20 (25%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	490..515	CDD:316026	10/24 (42%)
		C2H2 Zn finger	506..526	CDD:275368	7/24 (29%)
		C2H2 Zn finger	534..554	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910