DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF229

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_055333.3	Gene:	ZNF229 / 7772	HGNCID:	13022	Length:	825	Species:	Homo sapiens

Alignment Length:	696	Identity:	162/696 - (23%)
Similarity:	248/696 - (35%)	Gaps:	168/696 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEE---------------------- 110
            ||...||. |..:|.|:       ::||..||.::..:.|:||
Human    13 LHSQASAI-SQDREEKI-------MSQEPLSFKDVAVVFTEEELELLDSTQRQLYQDVMQENFRN 69

  Fly   111 -EGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDG 174
             ..|.|...||.:|....|. |::.||......| |......:|...:|.| ::..|..|:.:|.
Human    70 LLSVGERNPLGDKNGKDTEY-IQDEELRFFSHKE-LSSCKIWEEVAGELPG-SQDCRVNLQGKDF 131

  Fly   175 SSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVA---------------PPQ--------KPK 216
            ...:......|.|..:.|..|.:......:.|..:.               |.|        ...
Human   132 QFSEDAAPHQGWEGASTPCFPIENFLDSLQGDGLIGLENQQFPAWRAIRPIPIQGSWAKAFVNQL 196

  Fly   217 EDIQLDLKAEELDEFV-----DEETDPDFSCLV------------------------------PS 246
            .|:|...|..:.::.|     |:::....||.|                              |.
Human   197 GDVQERCKNLDTEDTVYKCNWDDDSFCWISCHVDHRFPEIDKPCGCNKCRKDCIKNSVLHRINPG 261

  Fly   247 DNSSEDDGGSDGFDSDSDF----------------ELDNGKQEFAVLPKRTVVRPKKYKKRTKPA 295
            :|..:.:...:||..|:|.                |...|.:..|.|.:.         :|....
Human   262 ENGLKSNEYRNGFRDDADLPPHPRVPLKEKLCQYDEFSEGLRHSAHLNRH---------QRVPTG 317

  Fly   296 EPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLP--CAICN--------LLVHNFTEMQRHHRLT 350
            |..|   :.|...|..:|..:.....:.....:|  |.:|.        ||:|......|.
Human   318 EKSV---KSLERGRGVRQNTHIRNHPRAPVGDMPYRCDVCGKGFRYKSVLLIHQGVHTGRR---- 375

  Fly   351 HQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTF 415
                |.....||:.|.:...|..|..||.....:|||.|.|.|..|..|:.||::|..   :..:
Human   376 ----PYKCEECGKAFGRSSNLLVHQRVHTGEKPYKCSECGKGFSYSSVLQVHQRLHTG---EKPY 433

  Fly   416 SCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKC 480
            :|..|.|.|.:|:|:..|   :|:...|..::|.||.|.|.....|.:|..: |..|....||||
Human   434 TCSECGKGFCAKSALHKH---QHIHPGEKPYSCGECGKGFSCSSHLSSHQKT-HTGERPYQCDKC 494

  Fly   481 GKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHI 543
            ||.......|:.||. :|..:     .|.:|.:||......:||..|.: :|   .||  ::|.
Human   495 GKGFSHNSYLQAHQR-VHMGQ-----HLYKCNVCGKSFSYSSGLLMHQR-LH---TGEKPYKCE- 548

  Fly   544 CAKVSPNARALRRHIYHN-HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFC 607
            |.|  ...|:...||:.. |..|:.:||:.|.|.|:|..:|..|...||||..|.|..|...|..
Human   549 CGK--SFGRSSDLHIHQRVHTGEKPYKCSECGKGFRRNSDLHSHQRVHTGERPYVCDVCGKGFIY 611

  Fly   608 SANMYKHRQRLHRAQ-----YEADKNQPKPPNILKISRNASTQNKP 648
            |:::..| ||:|..:     .|..|.......:| |.:...|..||
Human   612 SSDLLIH-QRVHTGEKPYKCAECGKGFSYSSGLL-IHQRVHTGEKP 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	5/12 (42%)
		FYDLN_acid	<191..268	CDD:302856	20/150 (13%)
		C2H2 Zn finger	330..351	CDD:275368	6/28 (21%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	9/20 (45%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/21 (29%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		5/13 (38%)
		KRAB	34..>74	CDD:214630	5/39 (13%)
		KRAB	34..73	CDD:279668	5/38 (13%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		COG5048	375..787	CDD:227381	93/311 (30%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		zf-H2C2_2	391..416	CDD:290200	10/24 (42%)
		C2H2 Zn finger	407..427	CDD:275368	9/19 (47%)
		zf-H2C2_2	420..442	CDD:290200	7/24 (29%)
		C2H2 Zn finger	435..455	CDD:275368	8/22 (36%)
		C2H2 Zn finger	463..483	CDD:275368	7/20 (35%)
		zf-H2C2_2	475..500	CDD:290200	10/25 (40%)
		C2H2 Zn finger	491..511	CDD:275368	9/20 (45%)
		C2H2 Zn finger	519..539	CDD:275368	6/20 (30%)
		C2H2 Zn finger	547..566	CDD:275368	6/21 (29%)
		zf-H2C2_2	562..583	CDD:290200	7/20 (35%)
		C2H2 Zn finger	574..594	CDD:275368	7/19 (37%)
		zf-H2C2_2	589..611	CDD:290200	9/21 (43%)
		C2H2 Zn finger	602..622	CDD:275368	7/20 (35%)
		zf-H2C2_2	614..639	CDD:290200	6/25 (24%)
		C2H2 Zn finger	630..650	CDD:275368	4/20 (20%)
		zf-H2C2_2	643..667	CDD:290200	5/14 (36%)
		C2H2 Zn finger	658..678	CDD:275368
		zf-H2C2_2	673..695	CDD:290200
		C2H2 Zn finger	686..706	CDD:275368
		zf-H2C2_2	698..723	CDD:290200
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	727..751	CDD:290200
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	754..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
		zf-H2C2_2	785..807	CDD:290200
		C2H2 Zn finger	798..818	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910