DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF208

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	459	Identity:	112/459 - (24%)
Similarity:	168/459 - (36%)	Gaps:	103/459 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 ELDNGKQEFAVLPKRTVVR--PKKYK-----KRTKPAEPKVR---------MSRELLEQRKKQQE 314
            |...|...|::|.|..|:.  .|.||     |.|...|...:         .|..|:|.:
Human   457 ECGKGFSMFSILTKHKVIHNGEKPYKCEECDKATHAGEKPYKCEECGKAFNWSSNLMEHK----- 516

  Fly   315 EYDVIIAKFFTSVLP--CAICNLLVHNFTEMQRH---------------------------HRLT 350
                   :..|...|  |..|......|:.:.:|                           |:..
Human   517 -------RIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKKI 574

  Fly   351 HQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKL 413
            |.|:..| .|  ||:.|.|..:|.:|..:|.....:||..|.|:|.....|.:|:.:|   |.:.
Human   575 HTVEKPY-KCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFSKVSTLTTHKAIH---AGEK 635

  Fly   414 TFSCDLCSKTFLSKTAIDYHK-----------------------LNKH--VPKSEFKFTCSECNK 453
            .:.|..|.|||:..:.:..||                       |.||  :...|..:.|.||.|
Human   636 PYKCKECGKTFIKVSTLTTHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGK 700

  Fly   454 KFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWL 518
            .|.....|..| ..:|..|....|::|||...|..:|.||:.:...:||      .:|:.||...
Human   701 AFNWSSNLMEH-KRIHTGEKPYKCEECGKSFSTFSVLTKHKVIHTGEKP------YKCEECGKAY 758

  Fly   519 KGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQEL 583
            |..:.|..|.|...||.  .::|..|.|....:..|.:| ...|..|:.:||..|.|.|.:...|
Human   759 KWSSTLSYHKKIHTVEK--PYKCEECGKAFNRSAILIKH-KRIHTDEKPYKCEECGKTFSKVSTL 820

  Fly   584 KEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YEADK--NQPKPPNILKISRNAST 644
            ..|.:.|.||..|.|..|...|...:.:.||:. :|..:  |:.::  ...|.|:.|...:...|
Human   821 TTHKAIHAGEKPYKCKECGKAFSKFSILTKHKV-IHTGEKPYKCEECGKAYKWPSTLSYHKKIHT 884

  Fly   645 QNKP 648
            ..||
Human   885 GEKP 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	1/1 (100%)
		C2H2 Zn finger	330..351	CDD:275368	5/47 (11%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	24/100 (24%)
		C2H2 Zn finger	417..438	CDD:275368	8/43 (19%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	37/174 (21%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200	2/5 (40%)
		C2H2 Zn finger	455..475	CDD:275368	6/17 (35%)
		C2H2 Zn finger	499..519	CDD:275368	3/31 (10%)
		zf-H2C2_2	511..536	CDD:290200	6/36 (17%)
		C2H2 Zn finger	527..547	CDD:275368	4/19 (21%)
		C2H2 Zn finger	555..575	CDD:275368	1/19 (5%)
		zf-H2C2_2	568..592	CDD:290200	8/24 (33%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	596..619	CDD:290200	7/22 (32%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	639..659	CDD:275368	7/19 (37%)
		C2H2 Zn finger	667..687	CDD:275368	3/19 (16%)
		COG5048	691..1133	CDD:227381	59/209 (28%)
		C2H2 Zn finger	695..715	CDD:275368	7/20 (35%)
		zf-H2C2_2	707..732	CDD:290200	8/25 (32%)
		C2H2 Zn finger	723..743	CDD:275368	8/19 (42%)
		C2H2 Zn finger	751..771	CDD:275368	7/19 (37%)
		zf-H2C2_2	764..788	CDD:290200	8/25 (32%)
		C2H2 Zn finger	779..799	CDD:275368	5/20 (25%)
		C2H2 Zn finger	807..827	CDD:275368	6/19 (32%)
		C2H2 Zn finger	835..855	CDD:275368	5/20 (25%)
		C2H2 Zn finger	863..883	CDD:275368	3/19 (16%)
		zf-H2C2_2	876..899	CDD:290200	4/13 (31%)
		C2H2 Zn finger	891..911	CDD:275368
		C2H2 Zn finger	919..939	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..995	CDD:275368
		C2H2 Zn finger	1003..1023	CDD:275368
		zf-H2C2_2	1015..1039	CDD:290200
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910