DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZSCAN26

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001018854.2	Gene:	ZSCAN26 / 7741	HGNCID:	12978	Length:	479	Species:	Homo sapiens

Alignment Length:	546	Identity:	118/546 - (21%)
Similarity:	188/546 - (34%)	Gaps:	170/546 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQD 156
            |..||.:..:|::|...|:..:..|:||        :.:::||.                .|:::
Human    80 LQPETHTKEQILELLVLEQFLIILPKEL--------QARVQEHH----------------PESRE 120

  Fly   157 QLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQL 221
            .:......|:..| .|.|..||.|:.:.......|.||.|..:.:..:.:..|..|:|.|
Human   121 DVVVVLEDLQLDL-GETGQQVDPDQPKKQKILVEEMAPLKGVQEQQVRHECEVTKPEKEK----- 179

  Fly   222 DLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPK 286
                       .|||                             .::|||   .::...:..|.:
Human   180 -----------GEET-----------------------------RIENGK---LIVVTDSCGRVE 201

  Fly   287 KYKKRTKP--------------AEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLV 337
            ...|.::|              |:||.::..:..|:.::..:..|:|
Human   202 SSGKISEPMEAHNEGSNLERHQAKPKEKIEYKCSEREQRFIQHLDLI------------------ 248

  Fly   338 HNFTEMQRHHRLTHQVDPGYMMC----CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRH 398
                    .|..||   .|..:|    |     |...|..|..|.......:|..|.|:||.|.|
Human   249 --------EHASTH---TGKKLCESDVC-----QSSSLTGHKKVLSREKGHQCHECGKAFQRSSH 297

  Fly   399 LESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKN 463
            |..||::|:                                  .|..:.|:||.|.|.....|..
Human   298 LVRHQKIHL----------------------------------GEKPYQCNECGKVFSQNAGLLE 328

  Fly   464 HMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHM 528
            |: .:|..|...:|..|||..|....|.:||.:...::|      .:|:.||........|..|.
Human   329 HL-RIHTGEKPYLCIHCGKNFRRSSHLNRHQRIHSQEEP------CECKECGKTFSQALLLTHHQ 386

  Fly   529 KSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGE 593
            : ||..|. .|:|:.|.|.......|.|| :..|..|:.|||.:|:|||:....|.:|...|..|
Human   387 R-IHSHSK-SHQCNECGKAFSLTSDLIRH-HRIHTGEKPFKCNICQKAFRLNSHLAQHVRIHNEE 448

  Fly   594 VLYTCPNCPMTFFCSANMYKHRQRLH 619
            ..|.|..|...|...:.:::| ||.|
Human   449 KPYQCSECGEAFRQRSGLFQH-QRYH 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	11/76 (14%)
		C2H2 Zn finger	330..351	CDD:275368	1/20 (5%)
		C2H2 Zn finger	360..378	CDD:275368	5/21 (24%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		zf-C2H2_8	389..465	CDD:292531	17/75 (23%)
		C2H2 Zn finger	417..438	CDD:275368	0/20 (0%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZSCAN26	NP_001018854.2	SCAN	47..135	CDD:280241	14/79 (18%)
		SCAN	52..158	CDD:128708	21/102 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..182		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..227		3/25 (12%)
		C2H2 Zn finger	234..254	CDD:275368	4/45 (9%)
		zf-C2H2	283..305	CDD:278523	10/21 (48%)
		C2H2 Zn finger	285..305	CDD:275368	10/19 (53%)
		COG5048	<290..469	CDD:227381	60/222 (27%)
		zf-H2C2_2	297..322	CDD:290200	11/58 (19%)
		C2H2 Zn finger	313..333	CDD:275368	7/20 (35%)
		zf-H2C2_2	326..350	CDD:290200	8/24 (33%)
		C2H2 Zn finger	341..361	CDD:275368	8/19 (42%)
		zf-H2C2_2	353..378	CDD:290200	7/30 (23%)
		C2H2 Zn finger	369..389	CDD:275368	5/20 (25%)
		C2H2 Zn finger	397..417	CDD:275368	6/20 (30%)
		zf-H2C2_2	409..432	CDD:290200	10/23 (43%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	8/24 (33%)
		C2H2 Zn finger	453..473	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910