DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF184

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	591	Identity:	145/591 - (24%)
Similarity:	224/591 - (37%)	Gaps:	127/591 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TLHEFVSAAQSSLQETKVALMEDDPLTQ-ETTSFPEIIKLA----------TQEEEGVTEPQELG 120
            ||..:.......||.:|     .|.::| |..:.|.|::.:          |:.|..|:.|:...
Human    57 TLENYTHLVSIGLQVSK-----PDVISQLEQGTEPWIMEPSIPVGTCADWETRLENSVSAPEPDI 116

  Fly   121 GRNFFYPEIKIEEHELDTLPRIEILE------RSANTQENQDQLEGAARRLRKRLKA-------- 171
            ......||:.:|:|:.|......:||      .....|.||..|....:...|.:.:
Human   117 SEEELSPEVIVEKHKRDDSWSSNLLESWEYEGSLERQQANQQTLPKEIKVTEKTIPSWEKGPVNN 181

  Fly   172 EDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEET 236
            |.|.||:...:    ..|.||:|.:....|..|.::  .|.:|.|
Human   182 EFGKSVNVSSN----LVTQEPSPEETSTKRSIKQNS--NPVKKEK-------------------- 220

  Fly   237 DPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRM 301
                ||      ...:.|.:..:.|            ..:..:||....|.||  ....|.....
Human   221 ----SC------KCNECGKAFSYCS------------ALIRHQRTHTGEKPYK--CNECEKAFSR 261

  Fly   302 SRELLEQRKKQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTE---MQRHHRLTHQVDPGYMMC- 360
            |..|:..:            :..|...|  |..|.   ..|.|   :.:|.|: |..:..| .|
Human   262 SENLINHQ------------RIHTGDKPYKCDQCG---KGFIEGPSLTQHQRI-HTGEKPY-KCD 309

  Fly   361 -CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTF 424
             ||:.|:||..|.:|..:|.....:.|:.|.|:|....|...||::|..   :..|.||.|.|||
Human   310 ECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTG---EKPFKCDECDKTF 371

  Fly   425 LSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL-TERKLKNHMSSMHDPESTIICDKCGKQMRTKI 488
            ...|.:..|   :.:...|..:.|:||.|.|. ....:::||  :|..|....|::|||......
Human   372 TRSTHLTQH---QKIHTGEKTYKCNECGKAFNGPSTFIRHHM--IHTGEKPYECNECGKAFSQHS 431

  Fly   489 ILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNA 551
            .|.:||:....:||      ..|..||......:.|.||:| ||   .||  ::|:.|.|.....
Human   432 NLTQHQKTHTGEKP------YDCAECGKSFSYWSSLAQHLK-IH---TGEKPYKCNECGKAFSYC 486

  Fly   552 RALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQ 616
            .:|.:| ...|..|:.|:|:.|.|||.....|.:|..|||.|..|.|..|...|..|:::.|| :
Human   487 SSLTQH-RRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKH-E 549

  Fly   617 RLHRAQ 622
            |:|..:
Human   550 RIHTGE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	3/13 (23%)
		FYDLN_acid	<191..268	CDD:302856	12/76 (16%)
		C2H2 Zn finger	330..351	CDD:275368	6/23 (26%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	22/76 (29%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630	9/35 (26%)
		KRAB	28..67	CDD:279668	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212		6/24 (25%)
		C2H2 Zn finger	224..244	CDD:275368	3/31 (10%)
		zf-H2C2_2	236..261	CDD:290200	6/26 (23%)
		COG5048	<248..409	CDD:227381	48/185 (26%)
		C2H2 Zn finger	252..272	CDD:275368	3/31 (10%)
		zf-H2C2_2	264..287	CDD:290200	5/37 (14%)
		C2H2 Zn finger	280..300	CDD:275368	6/23 (26%)
		zf-H2C2_2	292..317	CDD:290200	8/26 (31%)
		C2H2 Zn finger	308..328	CDD:275368	8/19 (42%)
		zf-H2C2_2	320..345	CDD:290200	7/24 (29%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		zf-H2C2_2	348..373	CDD:290200	11/27 (41%)
		COG5048	360..736	CDD:227381	67/213 (31%)
		C2H2 Zn finger	364..384	CDD:275368	8/22 (36%)
		zf-H2C2_2	376..400	CDD:290200	6/26 (23%)
		C2H2 Zn finger	392..412	CDD:275368	7/21 (33%)
		zf-C2H2	418..440	CDD:278523	7/21 (33%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..457	CDD:290200	8/30 (27%)
		C2H2 Zn finger	448..468	CDD:275368	7/20 (35%)
		zf-H2C2_2	460..485	CDD:290200	11/28 (39%)
		C2H2 Zn finger	476..496	CDD:275368	5/20 (25%)
		zf-H2C2_2	488..513	CDD:290200	10/25 (40%)
		C2H2 Zn finger	504..524	CDD:275368	7/19 (37%)
		zf-H2C2_2	516..541	CDD:290200	10/24 (42%)
		C2H2 Zn finger	532..552	CDD:275368	7/20 (35%)
		zf-H2C2_2	544..569	CDD:290200	4/13 (31%)
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
		zf-H2C2_2	628..653	CDD:290200
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	656..681	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..709	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910