DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF180

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens

Alignment Length:	686	Identity:	162/686 - (23%)
Similarity:	252/686 - (36%)	Gaps:	147/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VSAAQSSLQETKVALMEDDPL------TQETTSFPEIIKLATQEEEGVTEPQE------------ 118
            |.|..|.|.:..:..:|.:..      :||..:|..:....|:||:|...|.:
Human    41 VCAQDSFLPQEIIIKVEGEDTGSLTIPSQEGVNFKIVTVDFTREEQGTCNPAQRTLDRDVILENH 105

  Fly   119 -----------LGGRN------FFYPE----IKIEEHELDT--LPRIEILERSANTQENQDQ--- 157
                       :|.::      .|..|    :|||....|.  |...|.::...:..|.|.:
Human   106 RDLVSWDLATAVGKKDSTSKQRIFDEEPANGVKIERFTRDDPWLSSCEEVDDCKDQLEKQQEKQE 170

  Fly   158 --LEGAARRLRKRLKAEDGSSVDKDKDEDGVEET--AEPAPPKKRRGRPRKS-------DAAVAP 211
              |:..|...||.:..|.....|:..::.|:..:  :.|..|.:.......|       :|||..
Human   171 ILLQEVAFTQRKAVIHERVCKSDETGEKSGLNSSLFSSPVIPIRNHFHKHVSHAKKWHLNAAVNS 235

  Fly   212 PQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGF-DSDSDF---------- 265
            .||..|:       |.|.|..:....|....|:....:...| .|.|| |....|
Human   236 HQKINEN-------ETLYENNECGKPPQSIHLIQFTRTQTKD-KSYGFSDRIQSFCHGTPLHIHE 292

  Fly   266 ELDNGKQEFAVLPKRTVVRPK---KYKKRTKPAEPKVRMSR-----ELLEQRKKQQEE------- 315
            ::..|.:.|.......|:.||   ..::|....|.:.:.|.     .|.:..:...||
Human   293 KIHGGGKTFDFKECGQVLNPKISHNEQQRIPFEESQYKCSETSHSSSLTQNMRNNSEEKPFECNQ 357

  Fly   316 ---------YDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQ 367
                     :.|...:..|...|  |:.|.......:.:..|.| ||..:..| .|  ||:.|:|
Human   358 CGKSFSWSSHLVAHQRTHTGEKPYECSECGKSFSRSSHLVSHQR-THTGEKPY-RCNQCGKSFSQ 420

  Fly   368 RKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDY 432
            ..||..|...|.....::|:.|.|||:.|..|.:||:.|..   :..:.|:.|.|:|     |..
Human   421 SYVLVVHQRTHTGEKPYECNQCGKSFRQSYKLIAHQRTHTG---EKPYECNQCGKSF-----IQS 477

  Fly   433 HKLNKH--VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQE 495
            :||..|  :...|..:.|::|.|.|....||..|..: |..|....|::|||.......|..||.
Human   478 YKLIAHQRIHTGEKPYECNQCGKSFSQSYKLVAHQRT-HTGEKPFECNQCGKSFSWSSQLVAHQR 541

  Fly   496 LMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHI 558
            ....:||      .:|..||......:.|..|.: ||   .||  :.|:.|.|....:..|..|
Human   542 THTGEKP------YECSECGKSFNRSSHLVMHQR-IH---TGEKPYECNQCGKSFSQSYVLVVH- 595

  Fly   559 YHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQY 623
            ...|..|:.::|:.|.|:|::...|.:|..|||||..:.|..|..||..||.:..| ||.|..:
Human   596 QRTHTGEKPYECSQCGKSFRQSSCLTQHQRTHTGEKPFECNQCGKTFSLSARLIVH-QRTHTGE- 658

  Fly   624 EADKNQPKP----------PNILKISRNASTQNKPK 649
                   ||          .|..|:.|:.:|..:.|
Human   659 -------KPFTCIQCGKAFINSYKLIRHQATHTEEK 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	4/8 (50%)
		FYDLN_acid	<191..268	CDD:302856	20/94 (21%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	24/77 (31%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630	8/60 (13%)
		KRAB	72..111	CDD:279668	6/38 (16%)
		C2H2 Zn finger	249..267	CDD:275368	2/17 (12%)
		C2H2 Zn finger	275..295	CDD:275368	3/19 (16%)
		COG5048	332..692	CDD:227381	104/387 (27%)
		C2H2 Zn finger	355..375	CDD:275368	1/19 (5%)
		zf-H2C2_2	367..392	CDD:290200	5/24 (21%)
		C2H2 Zn finger	383..403	CDD:275368	4/20 (20%)
		zf-H2C2_2	395..420	CDD:290200	9/26 (35%)
		C2H2 Zn finger	411..431	CDD:275368	8/19 (42%)
		zf-H2C2_2	424..448	CDD:290200	8/23 (35%)
		C2H2 Zn finger	439..459	CDD:275368	9/19 (47%)
		zf-H2C2_2	455..476	CDD:290200	7/28 (25%)
		C2H2 Zn finger	467..487	CDD:275368	8/24 (33%)
		zf-H2C2_2	483..504	CDD:290200	6/20 (30%)
		C2H2 Zn finger	495..515	CDD:275368	7/20 (35%)
		zf-H2C2_2	508..531	CDD:290200	8/23 (35%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..560	CDD:290200	8/29 (28%)
		C2H2 Zn finger	551..571	CDD:275368	5/20 (25%)
		zf-H2C2_2	563..588	CDD:290200	9/28 (32%)
		C2H2 Zn finger	579..599	CDD:275368	5/20 (25%)
		zf-H2C2_2	592..616	CDD:290200	8/24 (33%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	620..643	CDD:290200	10/22 (45%)
		C2H2 Zn finger	635..655	CDD:275368	9/20 (45%)
		zf-H2C2_2	648..670	CDD:290200	6/30 (20%)
		C2H2 Zn finger	663..683	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910