DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp142

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001297597.1	Gene:	Zfp142 / 77264	MGIID:	1924514	Length:	1843	Species:	Mus musculus

Alignment Length:	797	Identity:	162/797 - (20%)
Similarity:	244/797 - (30%)	Gaps:	283/797 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEIL 145
            ||...:.|::|:.::..|.|....|.::|           ..|.|...:..|...|...|..|.|
Mouse   953 ETPALVAEEEPVVEKLASEPPRNPLISEE-----------APNTFKAALTAETVPLPPFPESESL 1006

  Fly   146 ERSANTQENQD---------------QLEGAARR------LRKRLKA------------------ 171
            .::...|:.:.               |.||.|.|      :.:|.||
Mouse  1007 LKAMRRQDKEQAEALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKALTLHSKSGCQGRREPLLC 1071

  Fly   172 -EDGSSV-------------------------------------DKDKDEDGVEETAEPAP---- 194
             |.|:|.                                     |....:|.......|.|
Mouse  1072 PECGASFKQQRGLSTHMMKKCPVLLKKNKALPKPVSPTLHPQLPDNQASQDAESRKPPPLPSKVE 1136

  Fly   195 --------------PKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEE-----TDPDF 240
                          |......|..||...:||:.       .|.....::|..|:     :...|
Mouse  1137 LLLPKDAPSDLPGGPGVEEPLPTPSDFPTSPPEN-------SLPTGTSEKFHFEQGKFHCSSCTF 1194

  Fly   241 SC--------------------------------LVPSDNSSE---DDGGSDGFDSDSDFELDNG 270
            .|                                ::|.:|...   :.|.::...||.|..:..
Mouse  1195 LCSRLSSITSHVTEGCRGGRGQKRKRGRPQTHAVVLPLNNGDSTLLNTGSTESSPSDGDTAVVQ- 1258

  Fly   271 KQE----------FAVLPKRTVVRPKKYKKR----------------TKPAEPKVRMSRELLEQR 309
            ||:          |:...:||:   :.::.:                |.||...:|     |.|:
Mouse  1259 KQKGALFSCPTCPFSCQQERTL---RTHQTQGCPLKSGDLHCGLCPFTAPAAAALR-----LHQK 1315

  Fly   310 KKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQ-VDPGYMMCCGRKFTQRKVLAE 373
            ::......   |.....:|.|..|.........:|:|.||.|: |.|.....|....|:|..|..
Mouse  1316 RRHPTASP---ASGPRPLLQCGDCGFTCKQSRCLQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEA 1377

  Fly   374 HVLVHWNPDHFKCSVCEKSFQNSRHLESHQ-QVH-MDPAVKLTFSCDLCSKTFLSKTAIDY---- 432
            |...|.......||.|.::|..:..|..|| :|| ..|    |..|.||          ||
Mouse  1378 HQSRHTGVGRIPCSSCPQTFGTNSKLRLHQLRVHDKTP----THFCPLC----------DYSGYL 1428

  Fly   433 -HKLNKHV---PKSEFKFTCSECNKKFLTERKLKNHMSSMHDPEST--------------IICDK 479
             |.:.:||   .:....|:|::|..:|.:|..||.|....| ||.|              :.|..
Mouse  1429 RHDITRHVNSCHQGTPSFSCTQCEAQFSSETALKQHALRRH-PEPTPPSSGCPVEVTEGPLHCSH 1492

  Fly   480 CGKQMRTKIILKKHQELMHSDKPRPE-----------PELQQ----------CQICGAWLKGMTG 523
            ||....:...|:.|....|   ||.|           |.|.:          ||:|....:...|
Mouse  1493 CGLLCPSPASLRGHTRKQH---PRLECGACQESFPNRPALDEHRRQHHFSHRCQLCSFAARERVG 1554

  Fly   524 LKQHMKSIHVES--------AGEHR--CHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFK 578
            |.:|....|.||        ||:..  |..|.....:...|..|: ..|...|.:|||.|..:.|
Mouse  1555 LVKHYLEQHEESSTAPSDGDAGQPSLCCPFCDFACRHQLVLDHHV-KGHGGTRLYKCTDCAYSTK 1618

  Fly   579 RPQELKEHTSTHTGEVLYTCPNCPMTFFCS-ANMYKHRQRLHRAQ---------YEADKNQPKPP 633
            ..|::..|:..||||..|.|..|  .:.|: .:..|:..|:|:.:         |:.     |..
Mouse  1619 NRQKITWHSRIHTGEKPYHCHLC--AYACADPSRLKYHMRIHKEERKYLCPECGYKC-----KWV 1676

  Fly   634 NILKISRNASTQNKPKQ 650
            |.||......|..||.|
Mouse  1677 NQLKYHMTKHTGLKPYQ 1693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	162/797 (20%)
		FYDLN_acid	<191..268	CDD:302856	19/134 (14%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/20 (35%)
		zf-C2H2_8	389..465	CDD:292531	24/85 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/25 (24%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/21 (24%)
Zfp142	NP_001297597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..357
		COG5048	335..781	CDD:227381
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	545..566	CDD:275368
		C2H2 Zn finger	574..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		C2H2 Zn finger	714..731	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..888
		rne	<866..>1015	CDD:236766	16/72 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1177		11/80 (14%)
		C2H2 Zn finger	1267..1296	CDD:275368	3/31 (10%)
		C2H2 Zn finger	1333..1354	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1362..1382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1390..1411	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1448..1469	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1490..1508	CDD:275368	5/17 (29%)
		C2H2 Zn finger	1516..1536	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1582..1602	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1610..1630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1638..1658	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1666..1686	CDD:275368	5/24 (21%)
		zf-H2C2_2	1679..1703	CDD:372612	6/15 (40%)
		C2H2 Zn finger	1694..1715	CDD:275368	162/797 (20%)
		C2H2 Zn finger	1723..1743	CDD:275368
		C2H2 Zn finger	1751..1771	CDD:275368
		C2H2 Zn finger	1779..1799	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1795..1843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910