DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF154

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001078853.1	Gene:	ZNF154 / 7710	HGNCID:	12939	Length:	437	Species:	Homo sapiens

Alignment Length:	377	Identity:	98/377 - (25%)
Similarity:	153/377 - (40%)	Gaps:	62/377 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 NSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQ 312
            ::|:.|||:......:.:..  |:...|...|.|:                |:..|.|..:|
Human   116 SNSKSDGGAISHRGKTHYNC--GEHTKAFSGKHTL----------------VQQQRTLTTER--- 159

  Fly   313 QEEYDVIIAKFFTSVLPCAICNLLVHNFTE---MQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEH 374
                             |.||:....:|::   :..|.||.....|.....||:.|.|...|.:|
Human   160 -----------------CYICSECGKSFSKSYSLNDHWRLHTGEKPYECRECGKSFRQSSSLIQH 207

  Fly   375 VLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHV 439
            ..||......:|..|.|.|.|..:|..|::||..   :..:.|..|.|:|..::|:..|   :.|
Human   208 RRVHTAVRPHECDECGKLFSNKSNLIKHRRVHTG---ERPYECSECGKSFSQRSALLQH---RGV 266

  Fly   440 PKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRP 504
            ...|..:.||||.|.|.....|..| ..:|.......|.:|||.......|.:|..:...::|
Human   267 HTGERPYECSECGKFFTYHSSLIKH-QKVHSGSRPYECSECGKSFSQNSSLIEHHRVHTGERP-- 328

  Fly   505 EPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERK 567
                .:|..||......:.|.|| :.:|   .||  :.|..|.|..|.:.:||:| ...|...|.
Human   329 ----YKCSECGKSFSQRSALLQH-RGVH---TGERPYECSECGKFFPYSSSLRKH-QRVHTGSRP 384

  Fly   568 FKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            ::|:.|.|:|.:...|.:|...||||..|.|..|..:|..::::.|| ||:|
Human   385 YECSECGKSFTQNSGLIKHRRVHTGEKPYECTECGKSFSHNSSLIKH-QRIH 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	4/19 (21%)
		C2H2 Zn finger	330..351	CDD:275368	7/23 (30%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF154	NP_001078853.1	KRAB	14..>62	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..129		4/12 (33%)
		C2H2 Zn finger	135..155	CDD:275368	6/37 (16%)
		COG5048	139..>436	CDD:227381	93/352 (26%)
		C2H2 Zn finger	163..183	CDD:275368	4/19 (21%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		C2H2 Zn finger	219..239	CDD:275368	7/19 (37%)
		zf-H2C2_2	231..256	CDD:290200	8/27 (30%)
		C2H2 Zn finger	247..267	CDD:275368	6/22 (27%)
		C2H2 Zn finger	275..295	CDD:275368	8/20 (40%)
		zf-H2C2_2	287..312	CDD:290200	7/25 (28%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..340	CDD:290200	6/30 (20%)
		C2H2 Zn finger	331..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	359..379	CDD:275368	7/20 (35%)
		zf-H2C2_2	371..396	CDD:290200	9/25 (36%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..424	CDD:290200	10/23 (43%)
		C2H2 Zn finger	415..435	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910