DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF79

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_009066.2	Gene:	ZNF79 / 7633	HGNCID:	13153	Length:	498	Species:	Homo sapiens

Alignment Length:	471	Identity:	116/471 - (24%)
Similarity:	183/471 - (38%)	Gaps:	74/471 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 PKKR--RGRPRKSDAAV---APPQKPKEDIQLD-------LKAEELDEFVDEETDPDFSCLVPSD 247
            |:.|  .|.|.||.:.|   .|..:|..:.||:       |:.|:|     ....|.:..:   .
Human    59 PRDRFKEGIPGKSRSLVLLGLPVSQPGMNSQLEQREGAWMLEGEDL-----RSPSPGWKII---S 115

  Fly   248 NSSEDDGGSDGFDSDSDFELDNGKQEFAV--LPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRK 310
            .|..:...|:....|...|:..|..:...  |.|...:||....::..|.|.:.|......|..|
Human   116 GSPPEQALSEASFQDPCVEMPPGDSDHGTSDLEKSFNLRPVLSPQQRVPVEARPRKCETHTESFK 180

  Fly   311 KQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAE 373
            ..:     |:.........|..|.......:.:.:|.: :|..:..| .|  ||:.|:|...|.:
Human   181 NSE-----ILKPHRAKPYACNECGKAFSYCSSLSQHQK-SHTGEKPY-ECSECGKAFSQSSSLIQ 238

  Fly   374 HVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH 438
            |..:|.....:|||.|.::|..:.:|..||:.|..   :..:.|..|.|.|...:|:..|   :.
Human   239 HQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTG---EKPYRCSECEKAFSDCSALVQH---QR 297

  Fly   439 VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPR 503
            :...|..:.||:|.|.|.....|.||..: |..|....|.:|||.........:||.:...:||
Human   298 IHTGEKPYECSDCGKAFRHSANLTNHQRT-HTGEKPYKCSECGKAFSYCAAFIQHQRIHTGEKP- 360

  Fly   504 PEPELQQCQICGAWLKGMTGLKQHMKS-----------------------IHVES-AGE--HRCH 542
                 .:|..||........|..|.::                       ||.:: .||  ::|:
Human   361 -----YRCAACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCN 420

  Fly   543 ICAK-VSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFF 606
            .|.| .|.::..:|.||.|..  |:.::|..|.|||.:...|.:|...|||...|.|..|...|.
Human   421 ECGKFFSESSALIRHHIIHTG--EKPYECNECGKAFNQSSSLSQHQRIHTGVKPYECSECGKAFR 483

  Fly   607 CSANMYKHRQRLHRAQ 622
            ||:...:| ||||..:
Human   484 CSSAFVRH-QRLHAGE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	19/84 (23%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/43 (12%)
		C2H2 Zn finger	541..562	CDD:275368	8/21 (38%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
ZNF79	NP_009066.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		KRAB	40..98	CDD:214630	11/38 (29%)
		KRAB_A-box	40..77	CDD:143639	7/17 (41%)
		C2H2 Zn finger	172..189	CDD:275368	3/21 (14%)
		C2H2 Zn finger	195..215	CDD:275368	3/20 (15%)
		COG5048	<206..437	CDD:227381	59/245 (24%)
		zf-H2C2_2	207..232	CDD:290200	7/26 (27%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		zf-H2C2_2	235..260	CDD:290200	8/24 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		zf-H2C2_2	263..287	CDD:290200	7/26 (27%)
		C2H2 Zn finger	279..299	CDD:275368	6/22 (27%)
		zf-H2C2_2	291..316	CDD:290200	8/27 (30%)
		C2H2 Zn finger	307..327	CDD:275368	8/20 (40%)
		zf-H2C2_2	319..344	CDD:290200	9/25 (36%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		zf-H2C2_2	350..372	CDD:290200	7/27 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..400	CDD:290200	2/24 (8%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		zf-H2C2_2	403..427	CDD:290200	7/23 (30%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..456	CDD:290200	10/26 (38%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..484	CDD:290200	9/24 (38%)
		C2H2 Zn finger	475..495	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910