DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF69

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	613	Identity:	130/613 - (21%)
Similarity:	227/613 - (37%)	Gaps:	112/613 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 DDPLT--------QETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEIL 145
            :||.|        |:..:|.::....||||..:.:..:    ...|.|:.:|     |...:..:
Human    11 EDPGTSESQEMMFQDPVAFDDVAVNFTQEEWALLDISQ----RKLYKEVMLE-----TFRNLTSV 66

  Fly   146 ERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVA 210
            .:|...|..:.:.:...|..|..::    ..|::.||:....||....|..:...:.:|:...:
Human    67 GKSWKDQNIEYEYQNPRRNFRSLIE----KKVNEIKDDSHCGETFTQVPDDRLNFQEKKASPEI- 126

  Fly   211 PPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSS-----EDDGGSDGFD----SDSDFE 266
                           :..|.||..|        |...|||     ..|.|...::    .....:
Human   127 ---------------KSCDSFVCGE--------VGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCK 168

  Fly   267 LDNGKQEFAVLPK-RTVVRPKKYKKRTKPAE----PKVRMSRELLEQRKKQQEEYDVIIAKFFTS 326
            ....|:.|...|. ||   |::.....||..    .|..:|...:::.............||...
Human   169 CQQPKKAFRYHPSFRT---PQRDHTGEKPYACKECGKTFISHSSIQRHVVMHSGDGPYKCKFCGK 230

  Fly   327 VLPCAICNLL---VH---------------NFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVL 371
            ...|....|:   :|               :::...|.|..||..:..| .|  ||:.|...:..
Human   231 AFHCLSLYLIHERIHTGEKPYECKQCGKSFSYSATLRIHERTHTGEKPY-ECQQCGKAFHSPRCY 294

  Fly   372 AEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLN 436
            ..|..:|.....::|..|.|:|...:::..|::.|   :.|..:.|..|.|...|.|:...| :.
Human   295 RRHERIHTGEKAYQCKECGKAFTCPQYVRIHERTH---SRKKPYECTQCGKALSSLTSFQTH-IR 355

  Fly   437 KHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDK 501
            .|  ..|..:.|..|.|.|.:....:.| ...|..|....|.:|||.......|:.|:.:...:|
Human   356 MH--SGERPYECKICGKGFCSANSFQRH-EKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEK 417

  Fly   502 PRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRH-----IY 559
            |      .:|:.||...:..:.|:.|.::    ..||  :.|..|.|...:.:.|:.|     ..
Human   418 P------YECKQCGKAFRSSSHLQLHGRT----HTGEKPYECQECGKAFRSMKNLQSHERTQTHV 472

  Fly   560 HNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ-- 622
            ..|..||.:||.:|.|.|..|:.|:.|..|||||.||.|..|... |.|::.:::.:|.|..:
Human   473 RIHSGERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQCGEA-FSSSSSFRYHERTHTGEKP 536

  Fly   623 YEADK--NQPKPPNILKISRNASTQNKP 648
            |:..:  ...:..::|::......::||
Human   537 YKCKQCGKAFRAASVLRMHGRTHPEDKP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	12/85 (14%)
		C2H2 Zn finger	330..351	CDD:275368	5/38 (13%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	9/38 (24%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	18/75 (24%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/25 (20%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630	9/48 (19%)
		KRAB	27..66	CDD:279668	9/47 (19%)
		C2H2 Zn finger	169..189	CDD:275368	6/22 (27%)
		C2H2 Zn finger	197..217	CDD:275368	2/19 (11%)
		COG5048	222..>540	CDD:227381	83/336 (25%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		zf-H2C2_2	241..262	CDD:290200	1/20 (5%)
		C2H2 Zn finger	253..273	CDD:275368	2/19 (11%)
		zf-H2C2_2	266..290	CDD:290200	9/24 (38%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		zf-H2C2_2	295..318	CDD:290200	6/22 (27%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	6/20 (30%)
		zf-H2C2_2	349..372	CDD:290200	6/25 (24%)
		C2H2 Zn finger	365..385	CDD:275368	5/20 (25%)
		zf-H2C2_2	377..400	CDD:290200	7/23 (30%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		zf-H2C2_2	405..430	CDD:290200	7/30 (23%)
		C2H2 Zn finger	421..441	CDD:275368	5/23 (22%)
		C2H2 Zn finger	449..468	CDD:275368	5/18 (28%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		zf-H2C2_2	495..520	CDD:290200	12/25 (48%)
		C2H2 Zn finger	511..531	CDD:275368	5/20 (25%)
		zf-H2C2_2	523..546	CDD:290200	3/22 (14%)
		C2H2 Zn finger	539..559	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910