DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and MZF1

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_005259261.1	Gene:	MZF1 / 7593	HGNCID:	13108	Length:	775	Species:	Homo sapiens

Alignment Length:	750	Identity:	168/750 - (22%)
Similarity:	248/750 - (33%)	Gaps:	242/750 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEG-------- 112
            ||.|..:.|.     ..|...:.|.....|..||:.        |.::||...||||
Human    29 GRHWPQIPDL-----VPSMRPAVLGSPDRAPPEDEG--------PVMVKLEDSEEEGEAALWDPG 80

  Fly   113 ---------------VTEPQELGG------RNFFYPEIKIEEHELDTLPRIEILER--SANTQEN 154
                           .|.|||...      |.:..||::.:|..|:.|    :||:  .|...|.
Human    81 PEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELL----VLEQFLGALPPEI 141

  Fly   155 QDQLEG-------AARRLRKRLKAE------------DGSSVDKDKDEDG----VEETAEPAPPK 196
            |.:::|       .|..|...|:.|            .|..|..:|.|..    :.||..|.|..
Human   142 QARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEP 206

  Fly   197 KRRGRPR-------------------KSDAAVAPPQKPKEDIQLDLKAEE-------LDE-FVDE 234
            ..:..||                   .||...:.|....::....|..||       ||: |...
Human   207 GPKTPPRTMQESPLGLQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHS 271

  Fly   235 ETDPD-------------------FS--------------------------------------- 241
            :|.|:                   ||
Human   272 KTGPEGPSWREHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSP 336

  Fly   242 ---------CLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKR--------TVVRPKKYK 289
                     .|:|||..||.|      .:|.|             |.|        |..|..:.:
Human   337 SREGGFAHALLLPSDLRSEQD------PTDED-------------PCRGVGPALITTRWRSPRGR 382

  Fly   290 KRTKPAE--PKVRMSR-----ELLEQRKKQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTEMQR 345
            .|.:|:.  ..||..|     ::..||......     .|..|...|  |:.|.......:.:.|
Human   383 SRGRPSTGGGVVRGGRCDVCGKVFSQRSNLLRH-----QKIHTGERPFVCSECGRSFSRSSHLLR 442

  Fly   346 HHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMD 408
             |:|||..:..: :|  ||:.|.:...|.||..||.....|:|:.|.:||:...:|..||::|.|
Human   443 -HQLTHTEERPF-VCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGD 505

  Fly   409 ---PAVKL-----------TFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTER 459
               |..|.           .|.|..|.::|..:..:..|:.   |...:..|.|.||.::|....
Human   506 PPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVLLEHQA---VHTGDKSFGCVECGERFGRRS 567

  Fly   460 KLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGL 524
            .|..| ..:|..|....|.:||:..|.:..|.:|:.:...::|      ..|..||...:....|
Human   568 VLLQH-RRVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERP------FACAECGKAFRQRPTL 625

  Fly   525 KQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHT 587
            .||:: :|   .||  ..|..|.:.......|.|| ...|..|:.:.|..|...|.:...|.||.
Human   626 TQHLR-VH---TGEKPFACPECGQRFSQRLKLTRH-QRTHTGEKPYHCGECGLGFTQVSRLTEHQ 685

  Fly   588 STHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            ..||||..:.||.|..:|...||:.:|| |:|..:
Human   686 RIHTGERPFACPECGQSFRQHANLTQHR-RIHTGE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	6/24 (25%)
		FYDLN_acid	<191..268	CDD:302856	26/170 (15%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	22/89 (25%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
MZF1	XP_005259261.1	SCAN	81..193	CDD:128708	24/115 (21%)
		COG5048	399..757	CDD:227381	91/343 (27%)
		C2H2 Zn finger	399..419	CDD:275368	3/24 (13%)
		C2H2 Zn finger	427..447	CDD:275368	5/20 (25%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275370	7/19 (37%)
		C2H2 Zn finger	528..548	CDD:275368	4/22 (18%)
		C2H2 Zn finger	556..576	CDD:275368	6/20 (30%)
		C2H2 Zn finger	584..604	CDD:275368	6/19 (32%)
		C2H2 Zn finger	612..632	CDD:275368	6/20 (30%)
		C2H2 Zn finger	640..660	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..688	CDD:275368	6/19 (32%)
		C2H2 Zn finger	696..716	CDD:275368	9/20 (45%)
		C2H2 Zn finger	724..744	CDD:275368
		C2H2 Zn finger	752..772	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910